Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome

Sandler, Brian; Aronson, Peter J.

doi:10.1016/0090-4295(93)90592-x

Cited by 54 publications

(17 citation statements)

References 7 publications

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“…The patient was treated with corticosteroids and regained normal renal function within 2 wk. The authors concluded that this was yohimbine-induced systemic lupus erythematosus with resultant renal dysfunction (37).…”

Section: Pausinystalia Yohimbe (Yohimbe)mentioning

confidence: 99%

A Review of Dietary Supplement–Induced Renal Dysfunction

Gabardi

Munz²,

Ulbricht³

2007

Clinical Journal of the American Society of Nephrology

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Complementary and alternative medicine (CAM) is a multibillion-dollar industry. Almost half of the American population uses some form of CAM, with many using them in addition to prescription medications. Most patients fail to inform their health care providers of their CAM use, and physicians rarely inquire. Annually, thousands of dietary supplement-induced adverse events are reported to Poison Control Centers nationwide. CAM manufacturers are not responsible for proving safety and efficacy, because the Food and Drug Administration does not regulate them. However, concern exists surrounding the safety of CAM. A literature search using MEDLINE and EMBASE was undertaken to explore the impact of CAM on renal function. English-language studies and case reports were selected for inclusion but were limited to those that consisted of human subjects, both adult and pediatric. This review provides details on dietary supplements that have been associated with renal dysfunction and focuses on 17 dietary supplements that have been associated with direct renal injury, CAM-induced immune-mediated nephrotoxicity, nephrolithiasis, rhabdomyolysis with acute renal injury, and hepatorenal syndrome. It is concluded that it is imperative that use of dietary supplements be monitored closely in all patients. Health care practitioners must take an active role in identifying patients who are using CAM and provide appropriate patient education.

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Section: Pausinystalia Yohimbe (Yohimbe)mentioning

confidence: 99%

A Review of Dietary Supplement–Induced Renal Dysfunction

Gabardi

Munz²,

Ulbricht³

2007

Clinical Journal of the American Society of Nephrology

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“…They showed initial improvement with use of oral prednisone corticosteroid and continued resolution with Eucerin cream with 1% hydrocortisone (body) and betamethasone valerate 0.1% cream (hands). 9 This account demonstrates that diffuse cutaneous reactions can occur as an acute response to drugs effective against ED.…”

Section: Adverse Eventsmentioning

confidence: 97%

Cutaneous Reaction to Drugs Used for Erectile Dysfunction: Case Report and Review of the Literature

2006

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“…To be included in the meta-analyses, reports had to identify the subjects as men with erectile disorder or impotence; include five or more subjects; report that yohimbine was administered orally, either by itself, or in combination with other medications; describe the dependent measure(s) employed to assess improvement; and provide information to allow derivation of improvement rate. Eight reports were excluded because they included fewer than five subjects (Friesen et al, 1993;Hollander and McCarley, 1992;Jacobsen, 1992;Pollack and Hammerness, 1993;Price and Grunhaus, 1990;Sandier and Aronson, 1993;Vickers et aL, 1993;Wolpowitz and Barnard, 1978). One additional report (Roberts and Sloboda, 1974) was excluded because its authors simply reanalyzed extant data already included.…”

Section: Sample Of Studies Included In Meta-analysesmentioning

confidence: 97%

Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations

Carey

Johnson

1996

Arch Sex Behav

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The results of four independent yet convergent meta-analyses to examine the efficacy of yohimbine in the treatment of erectile disorder are reported. These meta-analyses integrated data from (i) controlled clinical trials of yohimbine (when used alone), (ii) uncontrolled trials examining yohimbine (alone), (iii) controlled trials of yohimbine when used in combination with other drugs, and (iv) uncontrolled trials of yohimbine plus other drugs. Results document a consistent tendency for yohimbine, and for other medications containing yohimbine, to enhance erectile functioning relative to placebo. We also identify methodological and reporting difficulties that characterize much of the literature.

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Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome

Cited by 54 publications

References 7 publications

A Review of Dietary Supplement–Induced Renal Dysfunction

A Review of Dietary Supplement–Induced Renal Dysfunction

Cutaneous Reaction to Drugs Used for Erectile Dysfunction: Case Report and Review of the Literature

Effectiveness of yohimbine in the treatment of erectile disorder: Four meta-analytic integrations

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