Yolk @ cage-Shell Hollow Mesoporous Monodispersion Nanospheres of Amorphous Calcium Phosphate for Drug Delivery with High Loading Capacity

Huang, Suping; Li, Chunxia; Xiao, Qi

doi:10.1186/s11671-017-2051-7

Cited by 14 publications

(13 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently many researchers have paid more efforts to employ 3D printing to develop personalized medicines 11–13 and drug delivery system 14–21 . There are multiple 3D printing technologies utilized in customized medicines, such as Stereolithography (SLA) 22 , Selective Laser Sintering (SLS) 23,24 , Fused Deposition Modelling (FDM) 13,25,26 , Semi-solid extrusion (SSE) 27 and Powder Based (PB) 28 .…”

Section: Introductionmentioning

confidence: 99%

3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles

Zhao

Wang

et al. 2019

Sci Rep

View full text Add to dashboard Cite

The aim of this study was to explore the feasibility of using different 3D printed internal geometries as tablet formulations to obtain controlled release profiles. In order to obtain controllable release profiles, three types of tablet models (Cylinder, Horn and Reversed Horn) with controlled structures were designed. The cylinder model shows a constant release profile and can keep the drug concentration within a certain range. The horn model exhibits an increasing release profile, which is suitable for the patients who have the drug resistance in the course of medication. The reversed horn model has a decreasing release profile that would be applied to hypertension cure. Furthermore, three types of tablets were fabricated successfully by a fused deposition modeling three-dimensional (3D) printer and injected with paracetamol (APAP) -containing gels. The results of in vitro drug release demonstrate that tablets with three kinds of structures can produce constant, gradually increasing, and gradually decreasing release profiles, respectively. The release attributes can be controlled by using different 3D printed geometries as tablet formulations. More importantly, there are no residues after dissolution. The method of preparing customized tablets with distinguished release profiles presented in this study has the promising potential in the fabrication of patient-tailored medicines.

show abstract

Section: Introductionmentioning

confidence: 99%

3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles

Zhao

Wang

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Among them, loading capacity and release rate are related to shell number, porosity, and pore size. [ 57,144–148 ] In general, for HoMSs of the same size, the one with more shells can achieve a larger drug loading capacity.…”

Section: Structure–performance Correlation Of Homssmentioning

confidence: 99%

Small Structures Bring Big Things: Performance Control of Hollow Multishelled Structures

et al. 2020

View full text Add to dashboard Cite

Hollow multishelled structures (HoMSs) have gained numerous achievements in broad scientific research fields. In the past decade, the rapid developments of synthetic methods and advanced characterization technologies have enriched HoMS family with abundant chemical compositions and geometric structures. In addition, the control in phase structure and surface structure of HoMSs have also been reported in recent years. With great efforts devoted to controlling the compositional and structural characteristics, such as shell composition, shell number, shell thickness, and intershell space, HoMSs have displayed their intrinsic temporal–spatial nature and proven to be fruitful in optimizing mass transport, storage, and release. This review first summarizes the compositional and structural control of HoMSs in three levels, that is, building subunits, assembled functional shells, and HoMSs. Subsequentially, the essential influence of composition and structure on mass transport, storage, and release is deeply discussed by highlighting the application of HoMSs in energy storage, catalysis, electromagnetic wave absorption, and drug delivery. Finally, the challenges and opportunities in the future development of HoMSs are forecasted.

show abstract

“…Finally, the yolk@cage-shell hollow mesoporous mono-dispersion nanospheres of ACP were successfully constructed. 47 DOX was loaded into the yolk@cageshell hollow ACP nanospheres. The difference in DOX absorption behavior may be different in various morphologies.…”

Section: The Synthesis Of Amorphous Calcium Phosphate (Acp) Nanosphermentioning

confidence: 99%