Yolk-shell nanovesicles endow glutathione-responsive concurrent drug release and T1 MRI activation for cancer theranostics

Liu, Dahai; Zhou, Zijian; Wang, Xinyu; Deng, Hongzhang; Sun, Lin; Lin, Haixin; Kang, Fei; Zhang, Yong; Wang, Zhantong; Yang, Weijing; Rao, Lang; Yang, Kuikun; Yu, Guocan; Du, Jianshi; Shen, Zheyu; Chen, Xiaoyuan

doi:10.1016/j.biomaterials.2020.119979

Cited by 47 publications

(25 citation statements)

References 64 publications

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“…Liu et al reported the formation of glutathione-responsive system in which SPIONPs presenting DOX-loaded PAA brushes formed complexes and were encapsulated inside nanovesicles. [111] The obtained nanovesicles responded to changes in glutathione concentration in vivo and lead to drug release and T1 contrast activation. Integrating biomedical imaging and multimodal therapies into one platform is attractive for enhanced anticancer efficacy.…”

Section: Triggered Drug Delivery and Therapymentioning

confidence: 97%

Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics

Wang

et al. 2020

Adv Healthcare Materials

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Responsive polymer brushes are a category of polymer brushes that are capable of conformational and chemical changes in response to external stimuli. They offer unique opportunities for the control of bio−nano interactions due to the precise control of chemical and structural parameters such as the brush thickness, density, chemistry, and architecture. The design of responsive brushes at the surface of nanomaterials for theranostic applications has developed rapidly. These coatings can be generated from a very broad range of nanomaterials, without compromising their physical, photophysical, and imaging properties. Although the use of responsive brushes for nanotheranostic remains in its early stages, in this review, the aim is to present how the systems developed to date can be combined to control sensing, imaging, and controlled delivery of therapeutics. The recent developments for such design and associated methods for the synthesis of responsive brushes are discussed. The responsive behaviors of homo polymer brushes and brushes with more complex architectures are briefly reviewed, before the applications of responsive brushes as smart delivery systems are discussed. Finally, the recent work is summarized on the use of responsive polymer brushes as novel biosensors and diagnostic tools for the detection of analytes and biomarkers.

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Section: Triggered Drug Delivery and Therapymentioning

confidence: 97%

Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics

Wang

et al. 2020

Adv Healthcare Materials

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“…Theranostics aim to deliver point-of-care diagnosis and treatment with the same nanoformulation [313]. Theranostic agents can monitor the accumulation of nanomedicine compounds at the target site, visualize biodistribution, quantify triggered drug release, and assess therapeutic efficacy [314][315][316]. One of the most important aspects of theranostics is the capability to predict response in individual patients, thus paving the way for personalized medicine [317].…”

Section: The Future Of Cancer Diagnostics and Imagingmentioning

confidence: 99%

Cancer nanotechnology: current status and perspectives

2021

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Modern medicine has been waging a war on cancer for nearly a century with no tangible end in sight. Cancer treatments have significantly progressed, but the need to increase specificity and decrease systemic toxicities remains. Early diagnosis holds a key to improving prognostic outlook and patient quality of life, and diagnostic tools are on the cusp of a technological revolution. Nanotechnology has steadily expanded into the reaches of cancer chemotherapy, radiotherapy, diagnostics, and imaging, demonstrating the capacity to augment each and advance patient care. Nanomaterials provide an abundance of versatility, functionality, and applications to engineer specifically targeted cancer medicine, accurate early-detection devices, robust imaging modalities, and enhanced radiotherapy adjuvants. This review provides insights into the current clinical and pre-clinical nanotechnological applications for cancer drug therapy, diagnostics, imaging, and radiation therapy.

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“…In another work, Chen and coworkers reported a kind of GSH-responsive nanovesicles with a yolk-shell structure, in which both therapeutic drugs (DOX) and MRI contrast agents were both encapsulated inside the nanovesicles. The obtained nanovesicles with restrained drug activity and quenched T 1 MRI contrast ability can respond to GSH in a tumor microenvironment and lead to both T 1 contrast activation and DOX release, thereby monitoring drug release by activated T 1 MRI signal (Liu D. et al, 2020).…”

Section: Using Nanocarriers To Improve Conventional Chemotherapy Drugs For Tumor Theranosticsmentioning

confidence: 99%

Activable Multi-Modal Nanoprobes for Imaging Diagnosis and Therapy of Tumors

et al. 2021

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Malignant tumors have become one of the major causes of human death, but there remains a lack of effective methods for tiny tumor diagnosis, metastasis warning, clinical efficacy prediction, and effective treatment. In this context, localizing tiny tumors via imaging and non-invasively extracting molecular information related to tumor proliferation, invasion, metastasis, and drug resistance from the tumor microenvironment have become the most fundamental tasks faced by cancer researchers. Tumor-associated microenvironmental physiological parameters, such as hypoxia, acidic extracellular pH, protease, reducing conditions, and so forth, have much to do with prognostic indicators for cancer progression, and impact therapeutic administrations. By combining with various novel nanoparticle-based activatable probes, molecular imaging technologies can provide a feasible approach to visualize tumor-associated microenvironment parameters noninvasively and realize accurate treatment of tumors. This review focuses on the recent achievements in the design of “smart” nanomedicine responding to the tumor microenvironment-related features and highlights state-of- the-art technology in tumor imaging diagnosis and therapy.

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Yolk-shell nanovesicles endow glutathione-responsive concurrent drug release and T1 MRI activation for cancer theranostics

Cited by 47 publications

References 64 publications

Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics

Responsive Polymer Brush Design and Emerging Applications for Nanotheranostics

Cancer nanotechnology: current status and perspectives

Activable Multi-Modal Nanoprobes for Imaging Diagnosis and Therapy of Tumors

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