Young age increases the risk of lymph node positivity in papillary thyroid cancer patients: a SEER data-based study

Wang, Jing; Li, Jianjun; Pan, Huayuan; Jiang, Chenghao; Liu, Song; Zhu, Zhou; Fang, Jing; Zheng, Xucai; Hong, Shikai; Wang, Shengying

doi:10.2147/cmar.s167774

Cited by 33 publications

(44 citation statements)

References 46 publications

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“…Compared with patients with older ages, patients with younger ages usually had tumors with higher malignancy or more aggressive histological features, which might ultimately lead to a higher tendency to liver metastasis or other forms of distant metastases. 22,23 Consistent with studies of other kinds of tumors, Chang et al reported that early onset patients were much more vulnerable to positive circumferential margins, venous invasion and perineural invasion in colorectal adenocarcinoma. 24 Multiple genetic alterations in younger patients also supported the hypothesis that tumor cells in the young were more susceptible to promoting DNA damage than in the old.…”

Section: Discussionsupporting

confidence: 59%

Development and Validation of a Nomogram to Predict Liver Metastasis in Patients with Pancreatic Ductal Adenocarcinoma: A Large Cohort Study

He¹,

Zhong

Cai³

et al. 2018

SSRN Journal

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These authors contributed equally to this workBackground: Few studies have explored the relationship between clinicopathological factors of patients with pancreatic ductal adenocarcinoma (PDAC) and liver metastasis. The aim of this study was to develop and validate a nomogram to predict liver metastasis in patients with PDAC. Patients and methods: Patients diagnosed with PDAC between 2004 and 2015 from the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively collected. The nomogram was established based on a logistic regression model. The precision of the nomogram was evaluated and compared using concordance index (C-index), and the area under receiver operating characteristic curve (AUC). The clinical use of nomogram was evaluated by making use of a decision curve analysis (DCA). Results: A total of 12,644 eligible patients, which were randomly divided into training (n=9,483) and validation cohorts (n=3,161), were included in this study. The nomograms, which were established on the basis of independent predictors, were well calibrated, and demonstrated good discriminative ability, with C-indexes of 0.784 for the training cohort and 0.790 for validation cohort. The values of AUC for training and validation cohort were 0.792 and 0.800, respectively. When other sites of distant metastases were included into this predictive system, the new predictive model demonstrated a better discriminative ability and greater net benefit in predicting liver metastasis in patients with PDAC in both the training and validation cohorts. Conclusion: Nomograms were constructed to predict liver metastasis in patients with PDAC. Validation revealed excellent discrimination and calibration of the nomograms, suggesting that the nomograms were well calibrated and could serve to improve the prediction of the risks of liver metastasis which can be used to guide the management of patients with PDAC.

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Section: Discussionsupporting

confidence: 59%

Development and Validation of a Nomogram to Predict Liver Metastasis in Patients with Pancreatic Ductal Adenocarcinoma: A Large Cohort Study

He¹,

Zhong

Cai³

et al. 2018

SSRN Journal

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“…Similar to our study, Andrew et al [20] found that the ipsilateral central LNM risk related to age was U-shaped with increased odds of metastases in younger and older patients. The number of cases analyzed in these studies [22] and showed that younger patients had an increased LNM risk regardless of T stage. However, since patients were grouped based on 10-yearly age increments, it was impossible for them to infer that LNM can disappear spontaneously with delayed surgery in immune competent young and middle-age patients.…”

Section: Discussionmentioning

confidence: 97%

“…A number of studies [18][19][20][21][22] have examined the association between patient age at diagnosis and LNM in PTC, but the conclusions have been inconsistent. A single institution study of 1226 patients with PTMC [18] demonstrated that middle-aged and elderly patients had a lower risk of LNM compared with young patients.…”

Section: Discussionmentioning

confidence: 99%

Lymph node metastasis in young and middle-aged papillary thyroid carcinoma patients: a SEER-based cohort study

et al. 2020

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Background: Lymph node metastasis (LNM) occurs frequently in young papillary thyroid carcinoma (PTC) patients, though the mortality rates are low. We aimed to analyze the relationship between age at diagnosis and LNM in PTC at a population level to elucidate the clinical behavior of PTC. Methods: Data of adult patients with surgically treated PTC and follicular thyroid carcinoma (FTC) were identified from the Surveillance, Epidemiology, and End Results (SEER) database (2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015) to investigate the relationship between age and clinical characteristics by curve estimation. The adjusted odds ratio of age and LNM rate were determined.Results: A total of 50,347 PTC (48,166) and FTC (2181) (median age: 45 and 50 years, respectively) patients met the inclusion criteria; 44.5% of those with PTC (21,428) had LNM. Rank-sum test analysis indicated differences in distribution of age in LNM-positive and LNM-negative PTC. The relationship between age, tumor size and LNM showed a quadratic curve in PTC. The mean tumor diameter and LNM rate correlated linearly with age in 18-59year-old patients. LNM rate decreased with age (R 2 = 0.932, P < .0001), especially women (R 2 = 0.951, P < .0001). Conclusion:In young and middle-aged PTC patients, LNM may resolve spontaneously with delayed diagnosis and management. Active surveillance of low-risk PTC is justified.

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“…In patients with muscle-invasive bladder urothelial carcinoma (MIBC), the evaluation of LN+ is very important for staging and decisions on treatment. Age is an independent predictor of LN+ in various cancers [ 7 – 9 ]. In an analysis of 46,077 patients with thyroid cancer, it was found that young patients were more likely to have LN+, regardless of the T stage [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Young age increases the risk of lymph-node metastasis in patients with muscle-invasive bladder urothelial carcinoma

et al. 2020

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Background The risk of positive lymph nodes in patients with muscle-invasive bladder urothelial carcinoma (MIBC) can be used to guide treatment recommendations. However, little is known about the effect of age on lymph node positivity (LN+). This study aimed to evaluate the effect of age on LN+ in MIBC. Methods We analyzed patients with stage T2–T4 bladder urothelial carcinoma who had not received preoperative radiotherapy, had at least one lymph node examined, and underwent cystectomy between 1998 and 2015. The Cochran–Armitage trend test and logistic univariate and multivariate analyses were used to evaluate the effect of age on LN+ in all T stages. Results In total, 15,624 patients with MIBC were identified, including 747 patients aged ≤50 years (4.78%), 2614 patients aged 50–59 years (16.73%), 4914 patients aged 60–69 years (31.45%), 5225 patients aged 70–79 years old (33.44%), and 2124 patients aged > 80 years (13.59%). In T2–T4 staging, LN+ was negatively correlated with age. After adjustment for several covariates, multivariate logistic regression analysis revealed that age was an independent risk factor for LN+. Conclusions In this large SEER analysis, Young patients with MIBC have a higher risk of lymph node metastasis. This finding is worthy of further study and may eventually affect the treatment decisions of young patients.

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Young age increases the risk of lymph node positivity in papillary thyroid cancer patients: a SEER data-based study

Cited by 33 publications

References 46 publications

Development and Validation of a Nomogram to Predict Liver Metastasis in Patients with Pancreatic Ductal Adenocarcinoma: A Large Cohort Study

Development and Validation of a Nomogram to Predict Liver Metastasis in Patients with Pancreatic Ductal Adenocarcinoma: A Large Cohort Study

Lymph node metastasis in young and middle-aged papillary thyroid carcinoma patients: a SEER-based cohort study

Young age increases the risk of lymph-node metastasis in patients with muscle-invasive bladder urothelial carcinoma

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