Young astringent persimmon tannin inhibits methicillin-resistant Staphylococcus aureus isolated from pork

Liu, Miaomiao; Yang, Kun; Wang, Jing; Zhang, Jie; Qi, Yiman; Wei, Xinyuan; Fan, Mingtao

doi:10.1016/j.lwt.2018.10.047

Cited by 42 publications

(31 citation statements)

References 37 publications

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“…These results are consistent with those reported from previous studies. A similar finding that persimmon tannin induced a significant decrease in intracellular ATP concentration of S. aureus has been reported by Liu et al [11]. Shi et al [12] exhibited that the addition of ferulic acid leads to a significant decline of the intracellular ATP concentration of Cronobacter sakazakii cells.…”

Section: Discussionsupporting

confidence: 84%

RETRACTED: In Vitro Antibacterial Activity and Mechanism of Vanillic Acid against Carbapenem-Resistant Enterobacter cloacae

Qian

Liu

et al. 2019

Antibiotics

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Vanillic acid (VA) is a flavoring agent found in edible plants and fruits. Few recent studies exhibited robust antibacterial activity of VA against several pathogen microorganisms. However, little was reported about the effect of VA on carbapenem-resistant Enterobacter cloacae (CREC). The purpose of the current study was to assess in vitro antimicrobial and antibiofilm activities of VA against CREC. Here, minimum inhibitory concentrations (MIC) of VA against CREC was determined via gradient diffusion method. Furthermore, the antibacterial mode of VA against CREC was elucidated by measuring changes in intracellular adenosine triphosphate (ATP) concentration, intracellular pH (pHin), cell membrane potential and membrane integrity. In addition, antibiofilm formation of VA was measured by crystal violet assay and visualized with field emission scanning electron microscopy (FESEM) and confocal laser scanning microscopy (CLSM). The results showed that MIC of VA against E. cloacae was 600 μg/mL. VA was capable of inhibiting the growth of CREC and destroying the cell membrane integrity of CREC, as confirmed by the decrease of intracellular ATP concentration, pHin and membrane potential as well as distinctive variation in cellular morphology. Moreover, crystal violet staining, FESEM and CLSM results indicated that VA displayed robust inhibitory effects on biofilm formation of CREC and inactivated biofilm-related CREC cells. These findings revealed that VA exhibits potent antibacterial activity against CREC, and thus has potential to be exploited as a natural preservative to control the CREC associated infections.

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Section: Discussionsupporting

confidence: 84%

RETRACTED: In Vitro Antibacterial Activity and Mechanism of Vanillic Acid against Carbapenem-Resistant Enterobacter cloacae

Qian

Liu

et al. 2019

Antibiotics

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“…Persimmons could have other roles such as in the preservation of food, as demonstrated for persimmon tannins that exhibited antimicrobial action counter to foodborne methicillin-resistant Staphylococcus aureus (MRSA) and may well be developed in theory as a replacement or supplement to manage the propagation and infection of MRSA in foods [ 208 ].…”

Section: Introductionmentioning

confidence: 99%

“…Persimmon tannins from young astringent persimmon fruits actively inhibited several MRSA isolated from retail pork where the minimum inhibitory concentrations (MICs) were 1000 μg/mL. Adding persimmon tannins caused bacterial membrane integrity decrease, serious cell wall and membrane damage, which led to membrane hyperpolarization, a reduction in intracellular ATP concentration, whole cell protein and cycle depression, not to mention the morphological modifications [ 208 ]. The results presented by Liu and colleagues suggested that persimmon tannins from astringent young fruit can be used in the food and medical industries to inhibit the growth of MRSA.…”

Section: Introductionmentioning

confidence: 99%

“…The results presented by Liu and colleagues suggested that persimmon tannins from astringent young fruit can be used in the food and medical industries to inhibit the growth of MRSA. Further research is required on the large-scale extraction and purification of persimmon tannins as well as their impacts on the organoleptic characteristics of foods before commercial applications are to be considered [ 208 ].…”

Section: Introductionmentioning

confidence: 99%

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From Diospyros kaki L. (Persimmon) Phytochemical Profile and Health Impact to New Product Perspectives and Waste Valorization

et al. 2021

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Persimmon (Diospyros kaki L.) fruit’s phytochemical profile includes carotenoids, proanthocyanidins, and gallic acid among other phenolic compounds and vitamins. A huge antioxidant potential is present given this richness in antioxidant compounds. These bioactive compounds impact on health benefits. The intersection of nutrition and sustainability, the key idea behind the EAT-Lancet Commission, which could improve human health and decrease the global impact of food-related health conditions such as cancer, heart disease, diabetes, and obesity, bring the discussion regarding persimmon beyond the health effects from its consumption, but also on the valorization of a very perishable food that spoils quickly. A broad option of edible products with better storage stability or solutions that apply persimmon and its byproducts in the reinvention of old products or even creating new products, or with new and better packaging for the preservation of food products with postharvest technologies to preserve and extend the shelf-life of persimmon food products. Facing a global food crisis and the climate emergency, new and better day-to-day solutions are needed right now. Therefore, the use of persimmon waste has also been discussed as a good solution to produce biofuel, eco-friendly alternative reductants for fabric dyes, green plant growth regulator, biodegradable and edible films for vegetable packaging, antimicrobial activity against foodborne methicillin-resistant Staphylococcus aureus found in retail pork, anti-Helicobacter pylori agents from pedicel extracts, and persimmon pectin-based emulsifiers to prevent lipid peroxidation, among other solutions presented in the revised literature. It has become clear that the uses for persimmon go far beyond the kitchen table and the health impact consumption demonstrated over the years. The desired sustainable transition is already in progress, however, mechanistic studies and clinical trials are essential and scaling-up is fundamental to the future.

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“…researchers are therefore investigating natural broad-spectrum antibacterial agents that may be used to reduce the problem of drug resistance (8)(9)(10). Plant-derived compounds, including tannins, flavonoids, alkaloids and peptides have been reported to exhibit therapeutic action against bacterial infection (11)(12)(13), indicating their utility as antibacterial substances. antibacterial drugs are classified according to four mechanism of action: i) interference with cell wall synthesis; ii) causing damage to the plasma membrane; iii) inhibiting bacterial protein synthesis; and iv) affecting nucleic acid metabolism.…”

Section: Introductionmentioning

confidence: 99%

Possible mechanisms of the antimicrobial effects of polypeptide‑enriched Gastrodia elata Blume extracts

et al. 2019

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The present study aimed to evaluate the antimicrobial activity and the possible mechanisms of activity of polypeptide-enriched Gastrodia elata extracts (GeP) against the gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, the gram-positive bacterium Staphylococcus aureus and the fungus Candida albicans. The antimicrobial activity of GeP was first confirmed by determining the minimum inhibitory concentration by growth curve analysis. GeP was found to damage the cell wall and membrane of the microorganisms tested, as revealed by the morphological changes visible through scanning electron microscopy, and by the observed leakage of alkaline phosphatase and β-galactosidase from cells. GeP was demonstrated to perturb the metabolism of the microorganisms, especially the tricarboxylic acid cycle, as indicated by the reduced intracellular activity of succinate dehydrogenase, malate dehydrogenase and aTPases, including the na + /K +-aTPase and the ca2 +-aTPase. in addition, GeP caused the leakage of the genetic material of the bacteria and the fungus, as indicated by the increased od 260. The results of the present study indicated that GeP may exert its antimicrobial activity by damaging cell walls and membranes, causing the leakage of genetic material, and by perturbing cellular metabolism.

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Young astringent persimmon tannin inhibits methicillin-resistant Staphylococcus aureus isolated from pork

Cited by 42 publications

References 37 publications

RETRACTED: In Vitro Antibacterial Activity and Mechanism of Vanillic Acid against Carbapenem-Resistant Enterobacter cloacae

RETRACTED: In Vitro Antibacterial Activity and Mechanism of Vanillic Acid against Carbapenem-Resistant Enterobacter cloacae

From Diospyros kaki L. (Persimmon) Phytochemical Profile and Health Impact to New Product Perspectives and Waste Valorization

Possible mechanisms of the antimicrobial effects of polypeptide‑enriched Gastrodia elata Blume extracts

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