Young plasma transfer recovers decreased sperm counts and restores epigenetics in aged testis

Erdoğan, Kadriye; Ceylani, Taha; Teker, Hikmet Taner; Şengil, A. Zeki; Uysal, Fatma

doi:10.1016/j.exger.2022.112042

Cited by 7 publications

(7 citation statements)

References 35 publications

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“…Interestingly, we found young plasma could mitigate these age‐related changes, demonstrating therapeutic potential. Similar rejuvenating effects were seen in liver and testicular tissues 9,30 . Conversely, aged plasma negatively affected young rats.…”

Section: Discussionsupporting

confidence: 60%

“…Similar rejuvenating effects were seen in liver and testicular tissues. 9,30 Conversely, aged plasma negatively affected young rats.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, young plasma has been found to alleviate Alzheimer's disease‐related brain pathologies and improve cognitive impairments in animal models 8 . Recent investigations have also revealed that young plasma transfer not only increases sperm concentrations but also restores epigenetic patterns within the testes of aged animals 9 . These findings underscore the potential therapeutic applications of young plasma in addressing age‐related changes and rejuvenating tissues in various physiological systems.…”

Section: Introductionmentioning

confidence: 90%

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The rejuvenating influence of young plasma on aged intestine

Ceylani,

Teker,

Keskin

et al. 2023

J Cellular Molecular Medi

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This study aims to investigate the effects of plasma exchange on the biomolecular profiles and histology of ileum and colon tissues in young and aged Sprague–Dawley male rats. Fourier transform infrared (FTIR) spectroscopy, linear discriminant analysis and support vector machine (SVM) techniques were employed to analyse the lipid, protein, and nucleic acid indices in young and aged rats. Following the application of young plasma, aged rats demonstrated biomolecular profiles similar to those of their younger counterparts. Histopathological and immunohistochemical assessments showed that young plasma had a protective effect on the intestinal tissues of aged rats, increasing cell density and reducing inflammation. Additionally, the expression levels of key inflammatory mediators tumour necrosis factor‐alpha and cyclooxygenase‐2 significantly decreased after young plasma administration. These findings underscore the therapeutic potential of young plasma for mitigating age‐related changes and inflammation in the intestinal tract. They highlight the critical role of plasma composition in the ageing process and suggest the need for further research to explore how different regions of the intestines respond to plasma exchange. Such understanding could facilitate the development of innovative therapies targeting the gastrointestinal system, enhancing overall health during ageing.

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Section: Discussionsupporting

confidence: 60%

“…Similar rejuvenating effects were seen in liver and testicular tissues. 9,30 Conversely, aged plasma negatively affected young rats.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

See 1 more Smart Citation

The rejuvenating influence of young plasma on aged intestine

Ceylani,

Teker,

Keskin

et al. 2023

J Cellular Molecular Medi

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“…A recent study demonstrated a decrease in upregulated DNA methylation levels and a significant elevation in proliferating cell nuclear antigen expression after the transfusion of plasma from young animals to an older group. Moreover, the counts of spermatogonia and spermatocytes increased, similar to those in their younger counterparts [98]. Melatonin activated the PI3K/AKT signaling pathway and thereby increased sperm motility by promoting KIAA 1429-mediated m6A deposition [99].…”

Section: Epigenetic Modification-based Treatment For Senescent Sperma...mentioning

confidence: 59%

Role and Mechanism of Epigenetic Regulation in the Aging of Germ Cells: Prospects for Targeted Interventions

2024

Aging dis

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In modern times, a notable trend toward delayed childbearing has been observed in most developed countries. As a result, sperm aging and quality loss, as well as premature ovarian failure (POF), have emerged as major causes of infertility. The pathogenesis of sperm aging and POF is complex and has not been clearly elucidated. However, evidence from some studies has linked germ cell aging to epigenetic modifications. Epigenetics refers to the heritable changes in gene expression that occur in the absence of any alterations to the gene's nucleotide sequence. This paper systematically reviewed and analyzed the relevant literature to describe the relationship of DNA methylation, non-coding RNA regulation, histone modifications, chromatin remodeling, and RNA modifications with sperm aging and POF. In addition, we analyzed how sperm aging and POF can be mitigated via epigenetic interventions. This review could provide new therapeutic insights and guide strategies for improving sperm quality and ovarian function.

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“…In the process of aging, the liver undergoes significant transformations, including a decline in blood flow and regenerative capacity, accumulation of fat, decreased detoxification abilities, and gene expression alterations (19,20). These shifts can boost the risk of liver disease and other health issues in seniors.…”

Section: Discussionmentioning

confidence: 99%

Promoting Longevity in Aged Liver through NLRP3 Inflammasome Inhibition Using Tauroursodeoxycholic Acid (TUDCA) and SCD Probiotics

Baba,

Ceylani,

Acikgoz

et al. 2024

Preprint

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This study investigates the combined impact of SCD Probiotics and tauroursodeoxycholic acid (TUDCA) on the biomolecular makeup, histological changes and levels of inflammasome in the liver tissue of 24-month-old male Sprague-Dawley rats. By administering TUDCA (300 mg/kg, intravenously) and SCD Probiotics (3 mL (1 x 108 CFU), orally) daily for a week, the researchers employed ATR-FTIR spectroscopy along with machine learning approaches such as Linear Discriminant Analysis (LDA) and Support Vector Machine (SVM) to analyze the biomolecular profiles. In addition, the study measured the expression levels of inflammasome markers NLRP3, ASC, Caspase-1, IL18, and IL1β using RT-qPCR and examined liver sections for histopathological changes and NLRP3 inflammasome activation. The results revealed significant differences in the levels of lipids, proteins, and nucleic acids, with TUDCA having a noteworthy impact on enhancing lipid bands and reducing cholesterol ester bands, while SCD Probiotics showed the opposite effects. Furthermore, TUDCA was found to decrease the acyl chain length of fatty acids and improve protein conformation, whereas SCD Probiotics increased both the acyl chain length and protein phosphorylation ratio, suggesting a decrease in lipid and protein dynamics from both treatments. The histological assessments showed significant reductions in cellular degeneration, lymphatic infiltration, hepatic fibrosis, and the immunoreactivity of NLRP3 and ASC in the treated groups. SCD Probiotics exhibited a marked reduction in inflammasome-related gene expressions, and the lowest gene expression levels were observed in the group receiving both treatments. Despite an increase in serum AST and LDH levels across all groups, only the SCD Probiotics group showed an increase in albumin levels. The findings suggest that SCD Probiotics, TUDCA, and their combined administration may provide a promising avenue for therapeutic interventions in age-associated liver conditions and may mitigate age-related liver fibrosis while enhancing liver functionality.

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Young plasma transfer recovers decreased sperm counts and restores epigenetics in aged testis

Cited by 7 publications

References 35 publications

The rejuvenating influence of young plasma on aged intestine

The rejuvenating influence of young plasma on aged intestine

Role and Mechanism of Epigenetic Regulation in the Aging of Germ Cells: Prospects for Targeted Interventions

Promoting Longevity in Aged Liver through NLRP3 Inflammasome Inhibition Using Tauroursodeoxycholic Acid (TUDCA) and SCD Probiotics

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