Young’s modulus of trabecular bone at the tissue level: A review

Wu, Dan; Isaksson, Per; Ferguson, Stephen J.; Persson, Cecilia

doi:10.1016/j.actbio.2018.08.001

Cited by 168 publications

(89 citation statements)

References 104 publications

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“…For the mFE analyses, the default Young’s modulus of 10 GPa provided accurate results. This value is in good agreement with values reported from bending, tension, and nanoindentation test of wet human trabecular bone [16] but is considerably lower than values typically reported for cortical bone (~ 19 GPa). It is also less than the value found when comparing the stiffness of elastic specimens obtained from micro-FE models with experimental measurement [16, 17].…”

Section: Discussionsupporting

confidence: 90%

“…This value is in good agreement with values reported from bending, tension, and nanoindentation test of wet human trabecular bone [16] but is considerably lower than values typically reported for cortical bone (~ 19 GPa). It is also less than the value found when comparing the stiffness of elastic specimens obtained from micro-FE models with experimental measurement [16, 17]. Possible explanations for this discrepancy are the limited resolution of the models, the chosen threshold settings that will still result in some overestimation of the BV/TV [18], and the restrictive boundary condition used that can lead to an overestimation of the model stiffness (and hence underestimation of the tissue Young’s modulus) [19].…”

Section: Discussionsupporting

confidence: 90%

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Validation of distal radius failure load predictions by homogenized- and micro-finite element analyses based on second-generation high-resolution peripheral quantitative CT images

et al. 2019

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Summary This study developed a well-standardized and reproducible approach for micro-finite element (mFE) and homogenized-FE (hFE) analyses that can accurately predict the distal radius failure load using either mFE or hFE models when using the approaches and parameters developed in this study. Introduction Micro-FE analyses based on high-resolution peripheral quantitative CT (HR-pQCT) images are frequently used to predict distal radius failure load. With the introduction of a second-generation HR-pQCT device, however, the default modelling approach no longer provides accurate results. The aim of this study was to develop a well-standardized and reproducible approach for mFE and hFE analyses that can provide precise and accurate results for distal radius failure load predictions based on second-generation HR-pQCT images. Methods Second-generation HR-pQCT was used to scan the distal 20-mm section of 22 cadaver radii. The sections were excised and mechanically tested afterwards. For these sections, mFE and hFE models were made that were used to identify required material parameters by comparing predicted and measured results. Using these parameters, the models were cropped to represent the 10-mm region recommended for clinical studies to test their performance for failure load prediction. Results After identification of material parameters, the measured failure load of the 20-mm segments was in good agreement with the results of mFE models ( R 2 = 0.969, slope = 1.035) and hFE models ( R 2 = 0.966, slope = 0.890). When the models were restricted to the clinical region, mFE still accurately predicted the measured failure load ( R 2 = 0.955, slope = 1.021), while hFE predictions were precise but tended to overpredict the failure load ( R 2 = 0.952, slope = 0.780). Conclusions It was concluded that it is possible to accurately predict the distal radius failure load using either mFE or hFE models when using the approaches and parameters developed in this study. Electronic supplementary material The online version of this article (10.1007/s00198-019-04935-6) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Validation of distal radius failure load predictions by homogenized- and micro-finite element analyses based on second-generation high-resolution peripheral quantitative CT images

et al. 2019

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“…The highest value of Young's modulus 9.39 ± 0.71 GPa was observed for the annealed composite with 50 wt% of HAp. This value is close to the values of the human femur 34–36 and tibia 35,37 bone tissue nanoindentation, which confirms the potential successful osteointegration of such material in terms of load distribution and reducing the effect of stress shielding. Presumably, the growth of Young's modulus with an increase in the HAp weight fraction means reinforcing effect in the polymer matrix as a result of the homogeneous distribution of highly dispersed HAp powder assisted with HAp powder mechanical activation during mixing with PLLA solution.…”

Section: Resultssupporting

confidence: 84%

Highly filled poly(l‐lactic acid)/hydroxyapatite composite for 3D printing of personalized bone tissue engineering scaffolds

Dubinenko

Zinoviev

Bolbasov

et al. 2020

J of Applied Polymer Sci

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The designing of new biodegradable polymer composites is one of the most promising areas of modern orthopedics and regenerative surgery. At present, a number of methods have been proposed for designing and processing biodegradable polymer composites via various 3D printing technologies; however, the homogeneity of filler distribution together with mechanical properties of scaffolds made of such composites are far from those required for clinical use. In this study, the method for producing biodegradable composite material based on poly(l‐lactic acid) (PLLA) solution in organic solvent and hydroxyapatite (HAp) powder was proposed. The influence of HAp weight fraction and additional annealing on PLLA matrix crystallinity was investigated. It was shown that crystallinity of PLLA decreases from 58.84 ± 1.21 to 17.33 ± 1.69 as HAp weight fraction increased from 0 to 50 wt%. However, HAp filler promoted PLLA crystallites growth according to the X‐ray powder diffraction analysis. The results of nanoindentation showed Young's modulus values of the 3D‐printed scaffolds with 50 wt% of HAp at the level of human femur and tibia.

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“…Thus, the cells are in contact with biocompatible material of same stiffness as an osteointegrating bone. [59][60][61] The stiffness increased toward to bulk cpTi material. We can assume that by removing the mechanically incompatible transition we extend the life of the implant by limiting the micro-motions occurring on the ramp change of stiffness at the interface between bone and bulk titanium.…”

Section: Discussionmentioning

confidence: 99%

Different diameters of titanium dioxide nanotubes modulate Saos-2 osteoblast-like cell adhesion and osteogenic differentiation and nanomechanical properties of the surface

et al. 2019

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Young’s modulus of trabecular bone at the tissue level: A review

Cited by 168 publications

References 104 publications

Validation of distal radius failure load predictions by homogenized- and micro-finite element analyses based on second-generation high-resolution peripheral quantitative CT images

Validation of distal radius failure load predictions by homogenized- and micro-finite element analyses based on second-generation high-resolution peripheral quantitative CT images

Highly filled poly(l‐lactic acid)/hydroxyapatite composite for 3D printing of personalized bone tissue engineering scaffolds

Different diameters of titanium dioxide nanotubes modulate Saos-2 osteoblast-like cell adhesion and osteogenic differentiation and nanomechanical properties of the surface

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