Younger Females Are at Greater Risk of Vasodilation-Related Adverse Symptoms Caused by Dihydropyridine Calcium Channel Blockers: Results of a Study of 11,918 Japanese Patients

Kajiwara, Ayami; Saruwatari, Junji; Kita, Ayana; Oniki, Kentaro; Yamamura, Masato; Murase, Motoji; Koda, Haruo; Hirota, Seisuke; Ishizuka, Tadao; Nakagawa, Kazuko

doi:10.1007/s40261-014-0191-4

Cited by 17 publications

(7 citation statements)

References 17 publications

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“…Accordingly, persistence to antihypertensive therapy is increased in the presence of cardiovascular comorbidities. 13,32 Also, at the time of the study a blood pressure o130/80 mm Hg was recommended in patients with diabetes and cardiovascular disease. 33 An educational level of 10-12 years, being native Swede and the presence of psychiatric disorder increased the likelihood of reaching target blood pressure in women.…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive treatment and control according to gender, education, country of birth and psychiatric disorder: the Swedish Primary Care Cardiovascular Database (SPCCD)

et al. 2014

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The reasons why women and men are treated with different antihypertensive drugs are not clear. Whether socioeconomic factors influence prescription patterns and blood pressure control differently in women and men has not been investigated. This cross-sectional study performed in a cohort of hypertensive patients from the Swedish Primary Care Cardiovascular Database (SPCCD) examined the influence of educational level, country of birth, gender and concomitant psychiatric disorder on prescription pattern and blood pressure control in 40,825 hypertensive patients. Men were more often than women treated with calcium channel blocker and angiotensin-converting enzyme inhibitor (ACEI), irrespective of education, country of birth and psychiatric disorder. Educational level influenced the prescription pattern to some extent, where the gender differences were reduced in patients with a higher educational level. In women, but not in men, high educational level and concomitant psychiatric disorder were associated with a higher proportion reaching target blood pressure. The predominant use of ACEI and calcium channel blockers in men is not influenced by educational level, country of birth or psychiatric disorder. Thus other explanations must be considered such as gender differences in side effects. Educational level seems to have a greater impact on reaching target blood pressure in women compared with men.

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Section: Discussionmentioning

confidence: 99%

Antihypertensive treatment and control according to gender, education, country of birth and psychiatric disorder: the Swedish Primary Care Cardiovascular Database (SPCCD)

et al. 2014

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“…Additionally, when considering first-line antihypertensive therapeutic agents, women are more likely to be given diuretics and men are more likely to receive β-blockers, angiotensin-converting enzyme inhibitors (ACEI), and calcium channel blockers (CCB) [54][55][56]. One explanation for these therapeutic predilections could be the fact that related to side effects, women treated with ACEI tented to develop cough more often.…”

Section: Discussionmentioning

confidence: 99%

Arterial Hypertension: Individual Therapeutic Approaches—From DNA Sequencing to Gender Differentiation and New Therapeutic Targets

et al. 2021

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The aim of this paper is to provide an accurate overview regarding the current recommended approach for antihypertensive treatment. The importance of DNA sequencing in understanding the complex implication of genetics in hypertension could represent an important step in understanding antihypertensive treatment as well as in developing new medical strategies. Despite a pool of data from studies regarding cardiovascular risk factors emphasizing a worse prognosis for female patients rather than male patients, there are also results indicating that women are more likely to be predisposed to the use of antihypertensive medication and less likely to develop uncontrolled hypertension. Moreover, lower systolic blood pressure values are associated with increased cardiovascular risk in women compared to men. The prevalence, awareness and, most importantly, treatment of hypertension is variable in male and female patients, since the mechanisms responsible for this pathology may be different and closely related to gender factors such as the renin–angiotensin system, sympathetic nervous activity, endothelin-1, sex hormones, aldosterone, and the immune system. Thus, gender-related antihypertensive treatment individualization may be a valuable tool in improving female patients’ prognosis.

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“…At the end of the antihypertensive therapy, the uric acid level in the plasmasignificantly decreased in all comparison groups (p<0.05). In this case, this is important, since all patients received hydrochlorothiazide as the second antihypertensive drug, prolonged use of which leads to increasing of uric acid level in the plasma, which was defined as an independent predictor of death from cardiovascular causes 30 .…”

Section: Discussionmentioning

confidence: 99%

Gender-based differences in the effectiveness of antihypertensive therapy with losartan compared with enalapril

Cam¹,

Berestova

Lopatina

et al. 2021

Bangladesh J Med Sci

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Objective: Today there is a limited number of gender-based characteristics of the enalapril and losartanadministration in order to correct blood pressure in patients with arterial hypertension.The aim ofthe study was to compare the effectiveness of enalapril and losartan for blood pressure correcting inpatients with arterial hypertension (AH), depending on gender. Materials and methods: The studywas carried out in 2019 at Military Hospital 175 in Ho Chi Minh city, Vietnam. To achieve this goal,100 people were included in the study (50 females in the menopause and 50 males) with grade I-IIarterial hypertension aged 50 to 60 years. Patients with hypertension were divided into the followinggroups: group 1A – 25 males, who received enalapril 20 mg/d and 12.5 mg/d hydrochlorothiazideonce per day as antihypertensive therapy; group 1B – 25 males, who received losartan 50 mg/d andhydrochlorothiazide 12.5 mg/d once per day; group 2A – 25 females, who received enalapril 20 mg/dand hydrochlorothiazide 12.5 mg/d once per day; group 2B – 25 females, who received losartan 50mg/d and hydrochlorothiazide 12.5 mg/d once per day. The follow-up was 12 weeks. Results anddiscussion: The study showed that antihypertensive therapy with losartan is more effective in femalescompared with enalapril, as evidenced by a significant SBP decrease by 21.1% (p<0.05) at the endof treatment with losartan in females versus 18.6% (p<0.05) when using enalapril with the presenceof a statistically significant intergroup difference in the indicator (p<0.05). Conclusion: Our resultsindicate the presence of a gender difference in the antihypertensive effect of losartan and enalapril. Bangladesh Journal of Medical Science Vol.20(2) 2021 p.348-355

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Younger Females Are at Greater Risk of Vasodilation-Related Adverse Symptoms Caused by Dihydropyridine Calcium Channel Blockers: Results of a Study of 11,918 Japanese Patients

Cited by 17 publications

References 17 publications

Antihypertensive treatment and control according to gender, education, country of birth and psychiatric disorder: the Swedish Primary Care Cardiovascular Database (SPCCD)

Antihypertensive treatment and control according to gender, education, country of birth and psychiatric disorder: the Swedish Primary Care Cardiovascular Database (SPCCD)

Arterial Hypertension: Individual Therapeutic Approaches—From DNA Sequencing to Gender Differentiation and New Therapeutic Targets

Gender-based differences in the effectiveness of antihypertensive therapy with losartan compared with enalapril

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