Youngest case of ductal carcinoma in situ arising within a benign phyllodes tumour: A case report

Chopra, Sharat; Muralikrishnan, Vummiti; Brotto, Maurizio

doi:10.1016/j.ijscr.2016.04.053

Cited by 10 publications

(15 citation statements)

References 13 publications

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“…Some key histological factors are required to make the diagnosis of phyllodes tumors. Factors such as stromal overgrowth, hypercellularity, atypia, high mitosis rate, infiltrative borders and the presence of necrosis [1,2,4,6], are necessary to distinguish the tumor between benign and malignant phyllodes. Although, they have a structural similarity with its benign relative--the fibroadenoma, cystosarcoma phyllodes have more significant hypercellularity and overgrowth of the stromal protrusion.…”

Section: Discussionmentioning

confidence: 99%

“…Phyllodes tumors are further divided into three groups of benign, borderline or malignant tumors according to the World Health Organization (WHO) 2012 classification [1,2,4,[6], [7], [8],12]. The diagnostic criteria are also based on similar criteria for the initial diagnosis: stromal overgrowth, hypercellularity, atypia, high mitosis rate, infiltrative borders and the presence of necrosis.…”

Section: Discussionmentioning

confidence: 99%

“…Although extremely rare, all sub-divisions of phyllodes tumorcan harbor carcinomas. These carcinomas can be carried in two forms; either present as a separate lesion in the ipsilateral or contralateral breast; or inhabiting within the phyllodes tumor itself [[4], [5], [6], [7]]. Different kinds of carcinomas were reported in the literature: DCIS, tubular carcinoma, invasive ductal /lobular carcinoma, and squamous cell carcinoma [6,8].…”

Section: Discussionmentioning

confidence: 99%

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Coexisting DCIS and phyllodes breast tumors in Young Chinese women: Case series

Sun

Zhu

Ginter

et al. 2019

International Journal of Surgery Case Reports

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Highlights Breast cystosarcomaphyllodes tumors are rare and can be benign or malignant. These tumors can harbor carcinomas, although the incidence is extremely rare. Although challenging, the detection of a carcinoma component in phyllodes tumor is important, as it can dictate the need for lymph node sampling and possible adjuvant therapies such as radiation and systemic management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Coexisting DCIS and phyllodes breast tumors in Young Chinese women: Case series

Sun

Zhu

Ginter

et al. 2019

International Journal of Surgery Case Reports

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“…However, among the ten cases, only six had pure DCIS from benign phyllodes tumours, ours being the seventh case to be reported in the English literature. 5,15,19,33,36,39 The size of the phyllodes tumours ranged widely between 2.0 cm and 21.0 cm, suggesting that DCIS can occur in any palpable phyllodes tumour. Eight cases underwent wide local excision while the rest underwent total mastectomy.…”

Section: Discussionmentioning

confidence: 99%

Ductal carcinoma in-situ arising within benign phyllodes tumours

Wang

et al. 2018

annals

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Ductal carcinoma in situ arising within a benign phyllodes tumour is a rare neoplasm of the breast. We present a case of a 19-year-old woman who had a right breast lump for six months with the above diagnosis together with a mini-review of the literature. Ultrasound revealed a 5-cm breast lump and core biopsy revealed ductal carcinoma in situ. She underwent wide local excision of the breast lump with clear margins. Final histology confirmed ductal carcinoma in situ within a fibroepithelial lesion consistent with a benign phyllodes tumour. To our knowledge, this is the youngest case of ductal carcinoma in situ arising in a phyllodes tumour to have been reported so far.

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“…It is recommended that the treatment be customized in each case based on whether there is an invasive component, affected lymph nodes or distant metastases, and that the carcinomatous component be treated independently of the PT (8,9). Axillary lymph node dissection is not part of the standard treatment for phyllodes tumors as lymph node spread is rare.…”

Section: Di̇scussionmentioning

confidence: 99%

Ductal carcinoma in situ arising within a benign phyllodes tumor: A case report

Küçük¹,

Koçer²,

Şahin³

et al. 2018

Acta Oncol Tur.

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ÖZETFilloid tümör (FT), tüm meme tümörlerinin %1'inden azını oluşturan nadir bir fibroepitelyal neoplazmdır ve fibroepitelyal neoplazmların % 2-3'ünü oluşturur. FT'ün malign transformasyonu genellikle stromal komponentin de gerçekleşir ve epitelyal komponentde malign transformasyon nadiren görülür. DCIS, LCIS veya invaziv tümörler nadiren de olsa epitelyal komponent kaynaklı olabilir. Biz benign bir FT'de ortaya çıkan duktal karsinoma in situ (DCIS) olgusunu sunuyoruz. 38 yaşında multipar kadın hasta, sol meme üst dış kadranda sınırları belirsiz, düzensiz şekilli, sert, palpabl bir kitle şikayetiyle başvurmuş. Bu kitleden poliklinik koşullarında, ultrason eşliğinde kor biyopsi yapıldı ve biyopsi sonucu DCIS komponenti içeren benign FT olarak geldi. Hastaya segmental mastektomi uygulandı. Patoloji sonucu, duktal karsinoma in situ (DCIS) ile birliktelik gösteren benign filloids tümör şeklinde geldi. DCIS, epitelyal komponentin geniş bir alanı (epitelyal komponentin % 70'i) içinde gözlendi. Cerrahi sınır tümörden 1 mm uzaktaydı. Hastaya re-eksizyon uygulandı, ancak cerrahi sınır yakın geldi, bu nedenle hastaya implant rekonstrüksiyonu ile subkutan mastektomi uygulandı. Büyük boy filloid tümörler, Malign filloid tümörler veya epitelyal tümör içeren filloid tümörler, onkoplastik cerrahi teknikleri ile negatif cerrahi sınırla rezeke edilebilir. Böylece, filloid tümörlerde onkolojik ve kozmetik olarak başarılı sonuçlar elde etmek mümkündür. Anahtar Kelimeler: Filloid tümör, Duktal Karsinoma İn situ, Onkoplastik Cerrahi ABSTRACT Phyllodes tumor (PT) is a rare type of biphasic fibroepithelial neoplasm that accounts for <1% of all breast tumours and represents 2-3% of fibroepithelial neoplasms. Malignant transformation of PT usually occurs in the stromal component, and is rare in the epithelial component. DCIS, LCIS or invasive tumors might be due to epithelial component. We report a case of ductal carcinoma in situ (DCIS) occurring with in a benign PT. A 38-year-old multipar woman applied to an other medical center with compliants of a firm, palpable, irregularly-shaped lump with an ill-defined margin in the outer upper quadrant of the left breast. An ultrasound-guided core biopsy of this lump was done on an outpatient basis and the biopsy findings were benign PT with a DCIS component. The patients has undervent segmental mastectomy. The patology results were benign phyllodes tumor with Ductal Carcinoma In situ (DCIS). DCIS was also observed in a wide area of epithelial component (70% of epithelial component). The surgical margin were 1 mm away from the tumor. The patients had re-excision operation, however the surgical margin was still closed the margin so the patient had subcutaneous mastectomy with implant reconstruction. Large sized phyllodes tumors, malign phyllodes or epithelial tumors within phyllodes tumor can be resected with negative surgical margin with oncoplastic surgery techniques. Thus, it is possible to obtain successful results both in oncologic and cosmetically in phyllodes tumors.

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Youngest case of ductal carcinoma in situ arising within a benign phyllodes tumour: A case report

Cited by 10 publications

References 13 publications

Coexisting DCIS and phyllodes breast tumors in Young Chinese women: Case series

Coexisting DCIS and phyllodes breast tumors in Young Chinese women: Case series

Ductal carcinoma in-situ arising within benign phyllodes tumours

Ductal carcinoma in situ arising within a benign phyllodes tumor: A case report

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