Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice

Cheng, Li-Ling; Chen, Xi-Nan; Wang, Yu; Yu, Lu; Kuang, Xi; Wang, Lulu; Yang, Wude; Du, Jun-Rong

doi:10.1016/j.fitote.2011.07.011

Cited by 34 publications

(16 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Short-term working memory of mice was assessed using a Y-maze alternation task as previously described ( Cheng et al, 2011 ). Briefly, each mouse was placed at the end of one arm and allowed to move freely throughout the maze over the course of 5 min.…”

Section: Methodsmentioning

confidence: 99%

“…Ligustilide (LIG; 3-butylidene-4,5-dihydrophthalide) is the main lipophilic constituent of the Umbelliferae family of medicinal plants, including Radix angelicae sinensis and Ligusticum chuanxiong , and readily crosses the blood-brain barrier ( Chen et al, 2010 ). Our previous studies have shown that LIG exerts marked neuroprotective effects against several CNS pathologies including forebrain ischemic injury in ICR mice, permanent forebrain ischemia in rats, focal cerebral ischemia/reperfusion in rats, scopolamine induced memory impairment in mice, hydrogen peroxide-induced injury in PC12 cells, and lipopolysaccharide-induced inflammation in primary rat microglia ( Kuang et al, 2006 , 2008 , 2014a ; Yu et al, 2008 ; Wang et al, 2010 ; Cheng et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

Kuang

Zhou

Thorne

et al. 2017

Front. Aging Neurosci.

Self Cite

View full text Add to dashboard Cite

Emerging evidence suggests that alpha-processing single transmembrane proteins, amyloid precursor protein (APP) and anti-aging protein Klotho, are likely to be involved in the progression of Alzheimer’s disease (AD). The natural phthalide Ligustilide (LIG) has been demonstrated to protect against aging- and amyloid-β (Aβ)-induced brain dysfunction in animal models. The present study is to investigate the effects of LIG on cognitive deficits and metabolism of both APP and Klotho and its underlying mechanism in AD double-transgenic (APP/PS1) mice and cultured human cells. Our results show that treatment with LIG significantly ameliorated memory impairment and Aβ levels and plaques burden. Specifically, LIG might act as a potent enhancer of α-secretase, disintegrin, and metalloprotease 10 (ADAM10), leading to upregulation of alpha-processing of both APP and Klotho and subsequent increases in the levels of both soluble APP fragment (sAPPα) and soluble Klotho (sKL) with inhibition of IGF-1/Akt/mTOR signaling in AD mice and cultured cells. Moreover, the specific ADAM10 inhibitor (G1254023X) effectively reversed LIG-induced alpha-processing of both APP and Klotho in vitro, while Klotho gene knockdown by small interfering RNA significantly blunted LIG-mediated inhibition of IGF-1/Akt/mTOR signaling in vitro. Taken together with the reported neuroprotective effects of both sAPPα and sKL as well as autophagy induction by Akt/mTOR pathway inhibition, our findings suggest that neuroprotection of LIG against AD is associated with induction alpha-processing of APP and Klotho and potential Aβ clearance. Whether LIG might induce Aβ autophagic clearance and the underlying mechanisms need to be further studied.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

Kuang

Zhou

Thorne

et al. 2017

Front. Aging Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Angelicae Sinensis Radix Integra ( Dang - Gui ) is the key component of Bu - Zhong - Yi - Qi - Tang , Tian - Wang - Bu - Xin - Dan and Tao - Hong - Si - Wu - Tang . An ethanolic extract of Dang - Gui enhanced cholinergic function [ 31 ], inhibited acetylcholinesterase [ 32 ], reduced β -amyloid associated neurotoxicity and decreased Tau protein hyperphosphorylation in a dose-dependent manner [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Patterns of Chinese medicine use in prescriptions for treating Alzheimer’s disease in Taiwan

Lin

Yan

Tsai³

2016

Chin Med

View full text Add to dashboard Cite

BackgroundCertain Chinese medicine (CM) herbs and acupuncture may protect against Alzheimer’s disease (AD). However, there is a lack of research regarding the use of CM in patients with AD. The aim of this study was to investigate CM usage patterns in patients with AD, and identify the Chinese herbal formulae most commonly used for AD.MethodsThis retrospective, nationwide, population-based cohort study was conducted using a randomly sampled cohort of one million patients, selected from the National Health Insurance Research Database between 1997 and 2008 in Taiwan. CM use and the top ten most frequently prescribed formulae for treating AD were assessed, including average formulae dose and frequency of prescriptions. Demographic characteristics, including sex, age and insurance level were examined, together with geographic location. Existing medical conditions with the behavioral and psychological symptoms of dementia, and medications associated with CM were also examined. Factors associated with CM use were analyzed by multiple logistic regressions.ResultsThe cohort included 1137 newly diagnosed AD patients, who were given conventional treatment for AD between 1997 and 2008. Among them, 78.2 % also used CM treatments, including Chinese herbal remedies, acupuncture and massage manipulation. Female patients (aOR 1.57 with 95 % CI 1.16–2.13) and those living in urban areas (aOR 3.00 with 95 % CI 1.83–4.90 in the middle of Taiwan) were more likely to use CM. After adjusting for demographic factors, AD patients suffering from the behavioral and psychological symptoms of dementia were more likely to seek CM treatment than those with no symptoms (aOR 2.26 with 95 % CI 1.48–3.43 in patients suffering more than three symptoms). Bu-Zhong-Yi-Qi-Tang and Ji-Sheng-Shen-Qi-Wan were the two formulae most frequently prescribed by CM practitioners for treating AD.ConclusionMost people with AD who consumed herbal products used supplement qi, nourish the blood, and quiet the heart spirit therapy as complementary medicines to relieve AD-related symptoms, in addition to using standard anti-AD treatments.Electronic supplementary materialThe online version of this article (doi:10.1186/s13020-016-0086-9) contains supplementary material, which is available to authorized users.

show abstract

“…8,9 Ligustilide inhibits Ab1-40 toxicity on PC12 cells and ameliorates memory impairment induced by scopolamine in mice. 10 This compound could be developed into a therapeutic agent to prevent and treat ischaemic disorders. In addition, ferulic acid inhibits Ab1-40 toxicity on PC12 cells, provides neuroprotection against oxidative stress-related apoptosis aer cerebral ischemia/reperfusion injury in rats, and ameliorates memory impairment in a D-gal-induced aging mouse model.…”

Section: Introductionmentioning

confidence: 99%

Shunaoxin dropping pill, a Chinese herb compound preparation, attenuates memory impairment in d-galactose-induced aging mice

Zhou

Zhang

et al. 2018

RSC Adv.

View full text Add to dashboard Cite

show abstract

Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice

Cited by 34 publications

References 20 publications

Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

Neuroprotective Effect of Ligustilide through Induction of α-Secretase Processing of Both APP and Klotho in a Mouse Model of Alzheimer’s Disease

Patterns of Chinese medicine use in prescriptions for treating Alzheimer’s disease in Taiwan

Shunaoxin dropping pill, a Chinese herb compound preparation, attenuates memory impairment in d-galactose-induced aging mice

Contact Info

Product

Resources

About