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Ahmed, Shamim; Sileno, Anthony; deMeireles, J.C; Dua, Ramneik; Pimplaskar, H.K; Xia, Wei; Marinaro, Jonathan; Langenback, E. G.; Matos, Frank J.; Putcha, Lakshmi; Romeo, V. D.; Behl, Christian

doi:10.1023/a:1007551927177

Cited by 28 publications

(3 citation statements)

References 10 publications

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“…The addition of enhancers can increase the permeability of the epithelium up to 30-fold vs the natural state, allowing molecules up to 30 kDa to pass [69] . For many compounds, absorption is increased with lower pH, while the opposite is true for other compounds [70] , [71] , [72] , [73] . Excipients added to a formulation, such as permeation enhancers and mucoadhesive agents, may aid absorption ( Table 1 ).…”

Section: Drug Formulation Considerationsmentioning

confidence: 95%

The nose has it: Opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters

Chung¹,

Peters²,

Detyniecki³

et al. 2023

Epilepsy & Behavior Reports

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Section: Drug Formulation Considerationsmentioning

confidence: 95%

The nose has it: Opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters

Chung¹,

Peters²,

Detyniecki³

et al. 2023

Epilepsy & Behavior Reports

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“…These agents include buffers, cosolvents, absorption enhancers, mucoadhesives, and viscosity enhancers, which must balance the desired effect with the potential for toxicity and/or irritation in the formulation. For example, decreasing pH may increase the intranasal absorption of some drugs and decrease it for others, while sensitizing the nasal cavity as the formulation deviates from the natural pH of the nasal cavity (pH 5.5–6.5) [ 30 , 32 , 33 ], which carries a risk of local irritation [ 1 ].…”

Section: Challenges Of Nasal Drug Deliverymentioning

confidence: 99%

Optimizing Absorption for Intranasal Delivery of Drugs Targeting the Central Nervous System Using Alkylsaccharide Permeation Enhancers

2023

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Intranasal delivery of drugs offers several potential benefits related to ease of delivery, rapid onset, and patient experience, which may be of particular relevance to patients with central nervous system (CNS) conditions who experience acute events. Intranasal formulations must be adapted to address anatomical and physiological characteristics of the nasal cavity, including restricted dose volume, limited surface area, and barriers to mucosal absorption, in addition to constraints on the absorption window due to mucociliary clearance. Development of an effective formulation may utilize strategies including the addition of excipients to address the physicochemical properties of the drug within the constraints of nasal delivery. Dodecyl maltoside (DDM) and tetradecyl maltoside are alkylsaccharide permeation enhancers with well-established safety profiles, and studies have demonstrated transiently improved absorption and favorable bioavailability of several compounds in preclinical and clinical trials. Dodecyl maltoside is a component of three US Food and Drug Administration (FDA)–approved intranasal medications: diazepam for the treatment of seizure cluster in epilepsy, nalmefene for the treatment of acute opioid overdose, and sumatriptan for the treatment of migraine. Another drug product with DDM as an excipient is currently under FDA review, and numerous investigational drugs are in early-stage development. Here, we review factors related to the delivery of intranasal drugs and the role of alkylsaccharide permeation enhancers in the context of approved and future intranasal formulations of drugs for CNS conditions.

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“…Nasal medication administration is also noninvasive, which adds to its simplicity and safety. Furthermore, as compared to oral, sublingual, and transdermal drug delivery, nasal medication delivery resulted in a rapid onset of effect [ 28 ]. To be successful after intranasal delivery, a vaccine’s formulation must maintain antigen safety, provide the antigen enough time to connect with the lymphatic system, and activate both innate and cellular processes with or without the use of the healthy chemicals by attacking particular parts of the body, effective adjuvants immune cells that provide long-term protection from pathogens [ 11 ].…”

Section: Nasal Vaccinementioning

confidence: 99%

Nasal vaccine as a booster shot: a viable solution to restrict pandemic?

Meenakshi

Kumar

Dhingra

et al. 2022

Clin Exp Vaccine Res

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The coronavirus disease 2019 (COVID-19) pandemic revolutionized the vaccine market and initiated the momentum for alternative routes of administration for vaccines. The intranasal route of immunization is one such possibility that appears to be the most promising since it has some significant advantages, particularly in the prevention of respiratory infection. To analyze and summarize the role of nasal vaccines over conventional vaccines during COVID-19 and the need for the nasal vaccine as a booster shot. In this narrative review, the required data was retrieved using keywords “COVID-19,” “Intranasal,” “Immunity,” “Nasal spray,” and “Mucosal” in databases including PubMed, Scopus, Embase, Science Direct, and Web of Sciences. The results of the study showed that the nasal vaccines were both effective and protective according to the current researches approaching during the COVID-19 period and the preclinical and clinical phase trials prove the intranasal vaccination elicits more robust and cross-protective immunity than conventional vaccines. In this narrative review article, mechanisms across the nasal mucosa will be briefly presented and the current status of nasal vaccines during the COVID-19 pandemic is summarized, and advantages over traditional vaccines are provided. Furthermore, after exploring the primary benefits and kinetics of nasal vaccine, the potential for consideration of nasal vaccine as a booster dose is also discussed.

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Abstract: Nasal absorption of scopolamine hydrobromide in human subjects increased substantially with increases in formulation pH and dose.

Cited by 28 publications

References 10 publications

The nose has it: Opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters

The nose has it: Opportunities and challenges for intranasal drug administration for neurologic conditions including seizure clusters

Optimizing Absorption for Intranasal Delivery of Drugs Targeting the Central Nervous System Using Alkylsaccharide Permeation Enhancers

Nasal vaccine as a booster shot: a viable solution to restrict pandemic?

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