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Abstract

One-month therapy with trimetazidine sharply decreased the content of free radical oxidation products, lipid peroxides and malonic dialdehyde, in atherogenic low-density lipoproteins in patients with coronary heart disease. Activity of glutathione peroxidase utilizing lipid peroxides in the plasma markedly increased during trimetazidine therapy. The data suggest that trimetazidine not directly interacting with free radicals attenuates the adverse effects of intensive free radical oxidation in coronary heart disease. This effect is mediated via activation of antioxidant enzymes, which diminishes negative consequences of ischemia.

Trimetazidine Modulates Mitochondrial Redox Status and Disrupted Glutamate Homeostasis in a Rat Model of Epilepsy

“…In agreement with our results, Jain et al (2011) attributed the anticonvulsant activity of TMZ following PTZ-induced kindling in mice mainly to its robust antioxidant activity. The well-recognized antioxidant properties of TMZ are thought to be mediated indirectly by boosting the anti-oxidant enzymes (Tikhaze et al, 2000). This effect may be linked to the ability of TMZ to increase p-AMPK, which largely participates in restoring neuronal energy balance (Ronnett et al, 2009).…”

Oxidative stress in patients with chronic heart failure and type 2 diabetes mellitus

“…The kinetics of formazan formation was recorded on a Hitachi-557 spectrophotometer at 560 nm [7,9]. Erythrocyte catalase activity was estimated from H 2 O 2 utilization on a Hitachi 220A spectrophotometer [8]. Activity of Se-containing glutathione peroxidase in erythrocytes was measured in the glutathione reductase-coupled system.…”

Relationship between free-radical lipid oxidation and efficiency of coronary angioplasty in coronary patients

“…The duration of the lag phase of LDL oxidation was evaluated by kinetic curves, hydroperoxide content in LDL was evaluated by the reaction with Fe 2+ xylene orange before and after their reduction with triphenylphosphine on a Hitachi-557 spectrophotometer at λ=560 nm [9]. The content of MDA was evaluated by the reaction with TBA at λ=532 nm on a Hitachi-557 spectrophotometer [5]. Activity of erythrocyte Se-containing glutathione peroxidase was evaluated in a conjugated glutathione reductase system by the rate of NADPH oxidation at λ=340 nm with tert-butyl hydroperoxide as the substrate [5] on a Labsystems Oy FP-901 chemical analyzer in the kinetic mode.…”

“…The content of MDA was evaluated by the reaction with TBA at λ=532 nm on a Hitachi-557 spectrophotometer [5]. Activity of erythrocyte Se-containing glutathione peroxidase was evaluated in a conjugated glutathione reductase system by the rate of NADPH oxidation at λ=340 nm with tert-butyl hydroperoxide as the substrate [5] on a Labsystems Oy FP-901 chemical analyzer in the kinetic mode. The content of total cholesterol (CH), triglycerides, and HDL CH was measured by the enzymatic method on a Chiron Diagnostics biochemical analyzer using Bio Systems kits.…”