Zaltoprofen Loaded Solid Lipid Nanoparticles for Topical Delivery: Formulation Design, In Vitro and Ex Vivo Evaluation

Londhe, Vaishali; Save, Swarali

doi:10.15406/mojbb.2017.04.00065

Cited by 15 publications

(8 citation statements)

References 9 publications

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“…It was noted that there was a shift in the melting point from 115.77°C to 47.07°C (Figure 10b), indicating that AZT must be molecularly dispersed in the formulations. 21 The complete fusion of drug in the matrix was further proved by the thermograms of pure stearic acid and the blank SLN corresponds to F6 as shown in Figure 11.…”

Section: Dsc Studiesmentioning

confidence: 84%

Effect of Surfactant on Azithromycin Dihydrate Loaded Stearic Acid Solid Lipid Nanoparticles

Bhattacharyya¹,

Reddy²

2019

tjps

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ÖZAmaç: Azitromisin dihidrat, çeşitli bakteriyel enfeksiyon tiplerinin tedavisinde kullanılan bir makrolid antibiyotiktir. Etkin madde düşük çözünürlüğü nedeniyle düşük oral biyoyararlanım gösterir. Bu çalışmada, etken maddenin çözünürlüğünü ve çözünme hızını arttırmaya yönelik olarak azitromisin dihidratın katı lipit nanopartikülleri formüle edilmiştir. Gereç ve Yöntemler: Azitromisin dihidrat yüklü stearik asit nanopartikülleri, etken madde miktarını sabit tutarken, farklı lipit yüzey aktif madde oranında üç farklı yüzey aktif madde, Tween 20, Poloksamer 188 ve Poloksamer 407 kullanılarak yüksek hızlı homojenizasyon yöntemi ile formüle edilmiştir. Bu yöntemle on iki formülasyon hazırlanmıştır. Elde edilen nanopartiküller etken madde içeriği, % etken madde yükleme, % enkapsülasyon etkinliği, partikül boyutu analizi, zeta potansiyeli, yüzey morfolojisi, Fourier Transmisyon kızılötesi spektroskopisi, in vitro etken madde salımı, stabilite çalışması için değerlendirilmiştir. Bulgular: Tüm formülasyonlar, iyi yükleme etkinliği ve lenfatik absorpsiyon için uygun bir partikül büyüklüğü ile yüksek oranda in vitro salım göstermiştir. Poloksamer 188 ile formüle edilen nanopartiküller, diğer sürfaktanlara kıyasla daha iyi özellikler göstermiştir. Sonuç: Bu çalışma, yüksek hızlı homojenizasyon yöntemiyle hazırlanan azitromisin dihidratın stearik asit nanopartiküllerinin, çözünmenin ve dolayısıyla ilacın oral biyoyararlanımının iyileştirilmesi için kullanılabileceğini göstermiştir. Anahtar kelimeler: Azitromisin dihidrat, katı lipit nanopartiküller, zeta potansiyeli, partikül büyüklüğü, enkapsülasyon verimi, ilaç salımı Objectives: Azithromycin dihydrate is a macrolide antibiotic used for the treatment of several types of bacterial infections. The drug shows low oral bioavailability due to its low solubility. In the present work solid lipid nanoparticles of azithromycin dihydrate were formulated, keeping in view enhancement of the solubility and rate of dissolution of the drug. Materials and Methods: Azithromycin dihydrate loaded stearic acid nanoparticles were formulated by high shear homogenization using three different surfactants, namely Tween 20, poloxamer 188, and poloxamer 407, at a varied lipid surfactant ratio while keeping the quantities of the active ingredient constant. Twelve such formulations were prepared. The nanoparticles obtained were evaluated for drug content, % drug loading, % entrapment efficiency, particle size analysis, zeta potential, surface morphology, Fourier transmission infrared spectroscopy, in vitro drug release, and stability. Results: All the formulations showed good entrapment efficiency and high percentage of in vitro release with a particle size suitable for lymphatic absorption. The nanoparticles formulated with poloxamer 188 showed better characteristics compared to the other surfactants. Conclusion: This study indicates that stearic acid nanoparticles of azithromycin dihydrate prepared by high shear homogenization can be successively used for improvement of dissolution and thereby ora...

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Section: Dsc Studiesmentioning

confidence: 84%

Effect of Surfactant on Azithromycin Dihydrate Loaded Stearic Acid Solid Lipid Nanoparticles

Bhattacharyya¹,

Reddy²

2019

tjps

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“…The shift of peak reveals the reduced crystallinity of the drug, molecular dispersion of the drug in lipid matrix and hence high entrapment. 31 Overlay plots of DSC thermogram FP, blank formulation and optimized formulation are shown in Figure 5.…”

Section: Dscmentioning

confidence: 99%

Statistical Optimization Amalgamated Approach on Formulation Development of Nano Lipid Carrier Loaded Hydrophilic Gel of Fluticasone Propionate

Chandrashekar¹,

Bhattacharyya²

2021

IJPER

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Introduction: Formulation of a nano lipid carrier loaded hydrophilic gel of a corticosteroid, fluticasone propionate (FP) was investigated systemically with response surface model (RSM) for promising dermal delivery of the drug. Objectives: To achieve a better penetration of the drug and to overcome the generally associated adverse reactions of corticosteroids, the present study, explored the formulation and evaluation of nano lipid carriers (NLCs) of FP in a hydrophilic gel base. Methods: A central composite design was proposed to study the effect of processing materials on the physicochemical properties of the NLC. High shear homogenization method with stearic acid, isopropyl myristate and poloxamer 407 was used to make different batches of FP-NLCs. The model was optimized at a significance level of P<0.05. FTIR, DSC and surface morphology studies were carried out for the optimized product. The optimized product was incorporated in the Carbopol P940 gel base and was evaluated for its mechanical and rheological properties, ex-vivo permeation and skin irritation study. Results: It was observed that using the proposed model, a nano size (179 nm) stable (Zeta potential -26 mV) optimized product of FP-NLC with 85% entrapment efficiency was achieved. The nanogel exhibited a spreadability of 4.2 gm.cm/sec and a viscosity of 92.6 cp. Approximately 3.5 times improvement in ex-vivo permeation and no skin irritations on animals were reported on application of the nanogel of FP. Conclusion: Hence the investigation created a paradigm to explore the efficacy of nanogel of FP for dermal application with improved permeation and promising therapy for dermatitis.

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“…Samples were diluted with distilled water before analysis for better accuracy. Estimations were performed in triplicates, and the average was considered [12].…”

Section: Determination Of Particle Size Polydispersity Index and Zeta Potentialmentioning

confidence: 99%

“…Gel solution was subjected to shaking on a mechanical shaker to obtain complete solubility. The solution was estimated spectrophotometrically at 265 nm using methanol as solvent [12].…”

Section: Determination Of Viscosity and Percentage Drug Contentmentioning

confidence: 99%

Topical Delivery of Fenugreek Seed Extract Loaded Solid Lipid Nanoparticles Based Hydrogels for Alopecia

Ananth

Koland

2021

JPRI

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Background: Alopecia, a chronic dermatological inflammatory condition affecting the hair follicles. Conventional treatments are associated with the risk of serious side effects. The stratum corneum limits the percutaneous absorption of drugs. Hence, the development of novel herbal formulations for topical delivery has been the target, with the enhancement of their therapeutic efficacy and safety of use. Aims: To formulate and characterize Fenugreek seed extract loaded solid lipid nanoparticles carrier for the management of Alopecia to reduce the systemic side effects. Methodology: Fenugreek seed extract loaded solid lipid nanoparticles (SLN) were prepared by melt emulsification accompanied by probe sonication. The formulation was prepared using GMS, Tween 80, and Soya lecithin as Lipid, Surfactant, and Co-Surfactant. The SLN was incorporated into carbapol 934 dispersion to convert it into a gel. The SLN formulation was evaluated for size, Polydispersity Index, Zeta Potential, Entrapment efficiency, Transmission Electron Microscopy. After that, the SLN gel was examined for Spreadability, Extrudabilty, Viscosity, In vitro drug release, Ex vivo permeation, and Skin deposition studies. Results: The formulated Fenugreek seed extract loaded showed a particle size of 223.36 nm with a narrow PDI of 0.313. Entrapment efficiency revealed that 74.56±0.12% of the drug was entrapped. Transmission electron microscopy images confirmed the spherical nature of the SLN. The extended-release pattern of the formulated SLN for 24h was observed in the in vitro release studies and followed Higuchi model(R2=0.9964). Ex vivo permeability showed a 72.05±0.15% deposition of Fenugreek seed extract loaded SLN. The formulation was stable for three months without significant changes. Conclusion: Fenugreek seed extract loaded NLC demonstrated enhanced permeation, improved skin retention, and extended release compared to conventional gel. The developed formulation would be further used for in vivo studies and by seeing above results it can be an alternative for Alopecia in the future.

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Zaltoprofen Loaded Solid Lipid Nanoparticles for Topical Delivery: Formulation Design, In Vitro and Ex Vivo Evaluation

Cited by 15 publications

References 9 publications

Effect of Surfactant on Azithromycin Dihydrate Loaded Stearic Acid Solid Lipid Nanoparticles

Effect of Surfactant on Azithromycin Dihydrate Loaded Stearic Acid Solid Lipid Nanoparticles

Statistical Optimization Amalgamated Approach on Formulation Development of Nano Lipid Carrier Loaded Hydrophilic Gel of Fluticasone Propionate

Topical Delivery of Fenugreek Seed Extract Loaded Solid Lipid Nanoparticles Based Hydrogels for Alopecia

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