Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability

Hu, Tao; Luo, Zhiwen; Li, Kai; Wang, Shanjin; Wu, Desheng

doi:10.1042/bsr20201098

Cited by 8 publications

(4 citation statements)

References 43 publications

(51 reference statements)

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“…Recent data that BMP‐2 also induces inflammation have also been described 26 . One possible mechanism of inflammation induced by BMP‐2 is the production of inflammatory cytokines such as interleukin (IL)‐1α, IL‐1β, and TNF‐α 27 . We, therefore, speculate that NOB could enhance bone formation by reducing inflammation related to surgery and BMP‐2.…”

Section: Discussionmentioning

confidence: 84%

“… 26 One possible mechanism of inflammation induced by BMP‐2 is the production of inflammatory cytokines such as interleukin (IL)‐1α, IL‐1β, and TNF‐α. 27 We, therefore, speculate that NOB could enhance bone formation by reducing inflammation related to surgery and BMP‐2. Osteoclasts also reside in BMP‐2‐induced ectopic bones where marrow cavities (Figure 3C ) are present.…”

Section: Discussionmentioning

confidence: 94%

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Nobiletin, a NF‐κB signaling antagonist, promotes BMP ‐induced bone formation

et al. 2022

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The NF‐κB family of transcription factors plays an important role in skeletal development and bone homeostasis. In osteoblast cells, NF‐κB signaling has been shown to suppress survival, proliferation, and differentiation. Furthermore, pharmacological suppression of NF‐κB enhances osteoblast differentiation and bone formation. Thus, NF‐κB antagonists are promising candidates as anabolic agents for enhancing bone mass. In this study, we describe the mechanism by which nobiletin, an inhibitor of NF‐κB activity, regulates osteoblast differentiation and mineralization. We found that in MC3T3‐E1 osteoblast cells, nobiletin inhibited a TNF‐α responsive NF‐κB luciferase reporter and also decreased the induction of classical NF‐κB target genes by TNF‐α. Consistent with this, nobiletin prevented TNF‐α ‐mediated suppression of osteogenesis and potently enhanced the differentiation and mineralization of MC3T3‐E1 cells. Likewise, in an in vivo BMP2‐induced ectopic bone formation assay, nobiletin markedly enhanced ossicle bone volume. Western blotting and SMAD‐responsive luciferase assays also demonstrated that NF‐κB suppression of BMP signaling could be inhibited by nobiletin. Thus, our data suggest that mechanistically, nobiletin prevents the endogenous repression of BMP signaling by TNF‐α, thereby enhancing osteoblast activity. In conclusion, nobiletin is a novel NF‐κB antagonist that may be a useful anabolic agent for bone formation.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 94%

Nobiletin, a NF‐κB signaling antagonist, promotes BMP ‐induced bone formation

et al. 2022

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“…The inhibitory effect of BMP-2 on VE-cadherin has also been reported in studies related to complications of BMP-2. These studies considered that in BMP-2 induced inflammation, increased vascular permeability is caused by the downregulation of VE-cadherin and occludin, leading to inflammatory exudation. , However, after the combined utilization of VEGF and BMP-2, the effect of inducing angiogenic differentiation was stronger than that of the VP@PLLA group. The reason for this is unclear.…”

Section: Discussionmentioning

confidence: 99%

Polydopamine-Coated Poly(l-lactide) Nanofibers with Controlled Release of VEGF and BMP-2 as a Regenerative Periosteum

Sun

Dong

Wang

et al. 2021

ACS Biomater. Sci. Eng.

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The periosteum plays an important role in vascularization and ossification during bone repair. However, in most studies, an artificial periosteum cannot restore both functions of the periosteum concurrently. In this study, a novel nanofiber that can sustain the release of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) was fabricated to enhance the durability of angiogenesis and osteogenesis during bone regeneration. A cell-free tissue engineered periosteum based on an electrospinning poly-l-lactic acid (PLLA) nanofiber was fabricated, on which VEGF and BMP-2 were immobilized through a polydopamine (PDA) coating conveniently and safely (BVP@PLLA membrane). The results indicated a significantly improved loading rate as well as a slow and sustained release of VEGF and BMP-2 with the help of the PDA coating. BMP-2 immobilized on nanofibers successfully induced the osteogenic differentiation of human bone marrow mesenchymal stem cells (BMSCs) in vitro with high expression of runt-related transcription factor 2 (Runx2), osteopontin (OPN), and alkaline phosphatase (ALP). Similarly, angiogenic differentiation of BMSCs with the expression of fetal liver kinase-1 (Flk-1) and vascular endothelial cadherin (VE-cadherin) was observed under the environment of VEGF sustained release. Moreover, an in vivo study revealed that the BVP@PLLA membrane could enhance vascular formation and new bone formation, which accelerates bone regeneration in rat femoral defects along with a massive periosteum defect. Therefore, our study suggests that the novel artificial periosteum with dual growth factor controlled release is a promising system to improve bone regeneration in bone defects along with a massive periosteum defect.

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“…This domain is committed to the prevention and treatment of sports injuries and the enhancement of athletic performance (7,12,23,(27)(28)(29)(30). The scope of sports medicine encompasses but is not limited to, disciplines such as physiology, biomechanics, sports psychology, and sports nutrition (13,(31)(32)(33)(34)(35). Professionals in sports medicine frequently collaborate with physical therapists, sports psychologists, nutritionists, and experts from related fields to provide comprehensive services to athletes and the general populace.…”

Section: Introductionmentioning

confidence: 99%

Translational studies of exosomes in sports medicine – a mini-review

Huang,

Chen,

Feng

et al. 2024

Front. Immunol.

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This review in sports medicine focuses on the critical role of exosomes in managing chronic conditions and enhancing athletic performance. Exosomes, small vesicles produced by various cells, are essential for cellular communication and transporting molecules like proteins and nucleic acids. Originating from the endoplasmic reticulum, they play a vital role in modulating inflammation and tissue repair. Their significance in sports medicine is increasingly recognized, particularly in healing athletic injuries, improving articular cartilage lesions, and osteoarthritic conditions by modulating cellular behavior and aiding tissue regeneration. Investigations also highlight their potential in boosting athletic performance, especially through myocytes-derived exosomes that may enhance adaptability to physical training. Emphasizing a multidisciplinary approach, this review underlines the need to thoroughly understand exosome biology, including their pathways and classifications, to fully exploit their therapeutic potential. It outlines future directions in sports medicine, focusing on personalized treatments, clinical evaluations, and embracing technological advancements. This research represents a frontier in using exosomes to improve athletes’ health and performance capabilities.

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Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability

Cited by 8 publications

References 43 publications

Nobiletin, a NF‐κB signaling antagonist, promotes BMP ‐induced bone formation

Nobiletin, a NF‐κB signaling antagonist, promotes BMP ‐induced bone formation

Polydopamine-Coated Poly(l-lactide) Nanofibers with Controlled Release of VEGF and BMP-2 as a Regenerative Periosteum

Translational studies of exosomes in sports medicine – a mini-review

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