Mesotherapy is one of the minimally invasive methods that guarantee relatively quick and long-lasting effects. Its purpose can be considered on many levels, because the research conducted in this area points to more and more new applications for mesotherapy. This article presents skin areas that can be subjected to mesotherapy and examples of substances used to achieve a specific result. Currently, the most common reasons for people to take advantage of the procedure include: the progressive aging process, wrinkles, skin discoloration, acne scars, bruises under the eyes, flabbiness, dryness and loss of skin elasticity, lipodystrophy, stretch marks or excessive hair loss. For the effects of the treatment to be satisfactory and long-lasting, it is suggested to perform mesotherapy in series to maintain optimal skin condition.