ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor

Xiao, Guang‐Qian; Li, Faqian; Unger, Pamela; Katerji, Hani; Yang, Qi; McMahon, Loralee; Burstein, David

doi:10.1038/modpathol.2016.46

Cited by 34 publications

(14 citation statements)

References 46 publications

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“…In our previous study, we have shown that ZBTB16 is highly sensitive and specific for testicular YST . In this current study, we demonstrated further that ZBTB16 was also a sensitive marker for extragonadal and metastatic YSTs with an overall sensitivity of 91.6%, superior to AFP and GPC‐3.…”

Section: Discussionsupporting

confidence: 72%

ZBTB16 is a sensitive and specific marker in detection of metastatic and extragonadal yolk sac tumour

et al. 2017

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Aims Accurate histological diagnosis and classification of germ cell tumours (GCTs) is key to informing successful therapeutic and surveillance strategy. The modern therapeutic approach for yolk sac tumour (YST) is highly curative. Because YST takes on a large morphological spectrum, it can be confused for other GCT subtypes as well as somatic carcinomas, particularly when YST presents in an extragonadal or a metastatic setting. Currently available immunohistochemical markers are limited by suboptimal sensitivity and specificity. We reported recently that ZBTB16 is a sensitive and specific marker for testicular YST. ZBTB16 is absent in other GCTs and in most common somatic carcinomas, including those of gastrointestinal, pancreatobillary, respiratory, genitourinary and gynaecological tracts. The purpose of this study is to investigate the diagnostic utility of ZBTB16 in the settings of metastatic and extragonadal YST. Methods and results We studied 32 archived metastatic and four extragonadal primary YSTs as well as 51 somatic malignancies for their immunohistochemical expression of ZBTB16. For comparison, α‐fetoprotein (AFP) and glypican‐3 were also studied in parallel. Our results demonstrated an overall sensitivity of 91.6% for ZBTB16 in detecting metastatic and extragonadal YSTs. The non‐YST elements (teratoma and embryonal carcinoma) in 15 YST‐containing metastatic mixed GCTs were non‐reactive. With the exception of occasional myoepithelial cells of salivary gland carcinoma, all the 51 somatic malignancies were negative for ZBTB16. Conclusions ZBTB16 is a sensitive and specific marker for YST and is diagnostically superior to AFP and glypican‐3 in metastatic and extragonadal settings.

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Section: Discussionsupporting

confidence: 72%

ZBTB16 is a sensitive and specific marker in detection of metastatic and extragonadal yolk sac tumour

et al. 2017

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“…Contrariwise, we observed a "polyembryoma-like" and/or "necklace" pattern in a majority of Sensitivity was high in primary YST (100%), but specificity was 66% [17]. Sensitivity in identifying metastatic and extragonadal YST was lower (91.6%) [18].…”

Section: At Least 90% Of Testicular Tumors Are Germ Cell Tumors (Gctsmentioning

confidence: 89%

“…We would certainly recommend the use of an immunohistochemistry panel combining SALL4, HNF1, GPC3, OCT4, and possibly ZBTB16 according to Xiao et al. [17], in the evaluation of a mixed germ cell tumor, in order to adequately identify the YST and EC components.…”

Section: At Least 90% Of Testicular Tumors Are Germ Cell Tumors (Gctsmentioning

confidence: 99%

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors

Rougemont

Tille

2018

Human Pathology

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Identification of the yolk sac tumor (YST) component in germ cell tumors (GCT) may prove challenging, and highly sensitive and specific immunohistochemical markers are still lacking.Preliminary data from the literature suggest that HNF1 may represent a sensitive marker of YST. The specificity of HNF1 has not been addressed in GCT. A cohort of 49 YST specimens from 45 patients was designed, occurring either as pure tumors, or as a component of a mixed GCT. Immunohistochemistry was conducted on whole tumor sections using HNF1. SALL4, OCT4, CD30, CDX2, Cytokeratin 19, Glypican 3, and GATA3 were used for classification of the GCT components. Patients were mostly male (39/45), aged 14 months to 49 years, with primary testicular tumors (37/39), or primary mediastinal pure YSTs (2/39).All 6 primary tumors occurring in females (6/45) were pure ovarian YSTs; age range was 4 to 72 years. HNF1 nuclear reactivity was seen in the YST component in all 49 tumors, with a moderate to strong nuclear pattern of staining. Embryonal carcinoma (EC, 0/32) and seminoma (0/6) were negative. Choriocarcinoma (6/6) showed faint focal cytoplasmic reactivity to HNF1 but no nuclear staining. In teratomas, only enteric-type glands showed nuclear reactivity to HNF1 (11/16). Therefore, HNF1 sensitivity in YST component identification was 100% and specificity was 80%. Thus, in our experience, HNF1 is a sensitive and reliable marker of the YST component in GCT, and allows distinction of YST from intricately admixed EC, especially in the diffuse embryoma pattern. Abstract Word Count: 243

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“… 6 , 7 A recent study found that the zinc finger and BTB domain containing 16 (ZBTB16) is a novel, highly sensitive, and specific marker for distinguishing YSTs from other nonyolk sac GCTs. 8 …”

Section: Discussionmentioning

confidence: 99%

Primary yolk sac tumor of the gluteus: a case report and literature review

Jiang

Zhang

et al. 2016

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Yolk sac tumor (YST) is a common malignant primitive germ cell tumor that often exhibits differentiation into endodermal structures. They most commonly occur in childhood and adolescence and are rare after the age of 40 years. Derived from the yolk sac during the embryonic period, YSTs can occur in the gonads and germ cells because the tumor cells migrate from the yolk sac toward the gonads. Here, we present a rare case of primary gluteus YST in a 3-year-old girl. She received BEP chemotherapy (bleomycin + etoposide + cisplatin) after surgical resection. There was no evidence of recurrence 7 months after primary treatment.

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ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor

Cited by 34 publications

References 46 publications

ZBTB16 is a sensitive and specific marker in detection of metastatic and extragonadal yolk sac tumour

ZBTB16 is a sensitive and specific marker in detection of metastatic and extragonadal yolk sac tumour

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors

Primary yolk sac tumor of the gluteus: a case report and literature review

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