ZBTB20 in Nociceptive Neurons of the Trigeminal Ganglia Regulates Pruritus

Jia, Xiaomin; Dai, Meng-Han; Ren, An‐Jing; Wang, Tingting; Zhang, Weiping J.; Zhang, Ling

doi:10.3389/fmed.2021.626554

Cited by 4 publications

(3 citation statements)

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“…Behavioral tests of acute itch were performed as in previous studies. 28 , 29 Three days before the behavioral test, mice were shaved on the cheek. They were placed into small transparent plastic chambers (18 × 14 × 12 cm 3 ) for routine training (three consecutive days; 30 min per day).…”

Section: Methodsmentioning

confidence: 99%

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The G protein‐coupled estrogen receptor of the trigeminal ganglion regulates acute and chronic itch in mice

Gao

Zhang

et al. 2023

CNS Neurosci Ther

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AimsItch is an unpleasant sensation that severely impacts the patient's quality of life. Recent studies revealed that the G protein‐coupled estrogen receptor (GPER) may play a crucial role in the regulation of pain and itch perception. However, the contribution of the GPER in primary sensory neurons to the regulation of itch perception remains elusive. This study aimed to investigate whether and how the GPER participates in the regulation of itch perception in the trigeminal ganglion (TG).Methods and ResultsImmunofluorescence staining results showed that GPER‐positive (GPER+) neurons of the TG were activated in both acute and chronic itch. Behavioral data indicated that the chemogenetic activation of GPER+ neurons of the TG of Gper‐Cre mice abrogated scratching behaviors evoked by acute and chronic itch. Conversely, the chemogenetic inhibition of GPER+ neurons resulted in increased itch responses. Furthermore, the GPER expression and function were both upregulated in the TG of the dry skin‐induced chronic itch mouse model. Pharmacological inhibition of GPER (or Gper deficiency) markedly increased acute and chronic itch‐related scratching behaviors in mouse. Calcium imaging assays further revealed that Gper deficiency in TG neurons led to a marked increase in the calcium responses evoked by agonists of the transient receptor potential ankyrin A1 (TRPA1) and transient receptor potential vanilloid V1 (TRPV1).ConclusionOur findings demonstrated that the GPER of TG neurons is involved in the regulation of acute and chronic itch perception, by modulating the function of TRPA1 and TRPV1. This study provides new insights into peripheral itch sensory signal processing mechanisms and offers new targets for future clinical antipruritic therapy.

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Section: Methodsmentioning

confidence: 99%

“…Behavioral tests of acute itch were performed as in previous studies. 28,29 Three days before the behavioral test, mice were shaved on…”

Section: Acute Chemical Itchmentioning

confidence: 99%

The G protein‐coupled estrogen receptor of the trigeminal ganglion regulates acute and chronic itch in mice

Gao

Zhang

et al. 2023

CNS Neurosci Ther

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“…Zbtb20 has been shown to be present in GFAP+, S100β+, or Aldh1L1-GFP+ astrocytes in the forebrain and hippocampus, as well as in the gray and white matter of the spinal cord in rodents [ 11 , 285 ]. Other areas of the CNS containing Zbtb20+ cells include the postnatal olfactory bulb (in astrocytes and glomerular interneurons) [ 283 ], the hypothalamus (in neurons of the suprachiasmatic nucleus) [ 286 ], the cerebellum (in immature and migrating granule neurons) [ 281 , 287 ], and in the peripheral nervous system; ZBTB20 is found in developing dorsal root ganglia and mature sensory bipolar neurons [ 280 , 288 , 289 ], as well as in the subventricular zone of the telencephalon [ 283 ].…”

Section: Role Of Transcription Factors In Ischemic Brain Injurymentioning

confidence: 99%

Glial Populations in the Human Brain Following Ischemic Injury

Mihailova,

Stoyanova,

Tonchev

2023

Biomedicines

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There is a growing interest in glial cells in the central nervous system due to their important role in maintaining brain homeostasis under physiological conditions and after injury. A significant amount of evidence has been accumulated regarding their capacity to exert either pro-inflammatory or anti-inflammatory effects under different pathological conditions. In combination with their proliferative potential, they contribute not only to the limitation of brain damage and tissue remodeling but also to neuronal repair and synaptic recovery. Moreover, reactive glial cells can modulate the processes of neurogenesis, neuronal differentiation, and migration of neurons in the existing neural circuits in the adult brain. By discovering precise signals within specific niches, the regulation of sequential processes in adult neurogenesis holds the potential to unlock strategies that can stimulate the generation of functional neurons, whether in response to injury or as a means of addressing degenerative neurological conditions. Cerebral ischemic stroke, a condition falling within the realm of acute vascular disorders affecting the circulation in the brain, stands as a prominent global cause of disability and mortality. Extensive investigations into glial plasticity and their intricate interactions with other cells in the central nervous system have predominantly relied on studies conducted on experimental animals, including rodents and primates. However, valuable insights have also been gleaned from in vivo studies involving poststroke patients, utilizing highly specialized imaging techniques. Following the attempts to map brain cells, the role of various transcription factors in modulating gene expression in response to cerebral ischemia is gaining increasing popularity. Although the results obtained thus far remain incomplete and occasionally ambiguous, they serve as a solid foundation for the development of strategies aimed at influencing the recovery process after ischemic brain injury.

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Glial Populations in the Human Brain Following Ischemic Injury

Mihailova¹,

Stoyanova²,

Tonchev³

2023

Preprint

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There is a growing interest in glial cells in the central nervous system due to their important role in maintaining brain homeostasis both under physiological conditions and after injury. A significant amount of evidence has been accumulated regarding their capacity to exert either pro-inflammatory or anti-inflammatory effects under different pathological conditions. In combination with their known proliferative potential, they contribute not only to the limitation of brain damage and tissue remodeling but also to neuronal repair and synaptic recovery. Moreover, reactive glial cells can modulate the processes of neurogenesis, proliferation, and migration of neurons in the existing neural circuits in the adult brain. By discovering precise signals within specific niches, the regulation of sequential processes in adult neurogenesis holds the potential to unlock strategies that can stimulate the generation of functional neurons, whether in response to injury or as a means of addressing degenerative neurological conditions. Cerebral ischemic stroke, a condition falling within the realm of acute vascular disorders affecting the circulation of the brain, stands as a prominent global cause of disability and mortality. Extensive investigations into glial plasticity and their intricate interactions with other cells in the central nervous system have predominantly relied on studies conducted on experimental animals, including rodents and primates. However, valuable insights have also been gleaned from in vivo studies involving post-stroke patients, utilizing highly specialized imaging techniques. Following the attempts to map brain cells, the role of various transcription factors in modulating gene expression in response to cerebral ischemia is gaining increasing popularity. Although the results obtained thus far remain incomplete and occasionally ambiguous, they serve as a solid foundation for the development of strategies aimed at influencing the recovery process after ischemic brain injury.

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ZBTB20 in Nociceptive Neurons of the Trigeminal Ganglia Regulates Pruritus

Cited by 4 publications

References 40 publications

The G protein‐coupled estrogen receptor of the trigeminal ganglion regulates acute and chronic itch in mice

The G protein‐coupled estrogen receptor of the trigeminal ganglion regulates acute and chronic itch in mice

Glial Populations in the Human Brain Following Ischemic Injury

Glial Populations in the Human Brain Following Ischemic Injury

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