Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer

Xu, Zihang; Zhu, Yangzhuangzhuang; Su, Lin; Tang, Xueyang; Yao, Chao; Jiao, Xiaoning; Hou, Yifei; Xiao, Chen; Wei, Luyao; Wang, Wantao; Wang, Jie; Gong, Chenyuan; Zhu, Xiandan; Zhang, Fei; Zhu, Shuchai; C, Zou

doi:10.1155/2021/8856326

Cited by 13 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, an increasing number of researchers have begun to pay attention to nature compounds which have good antitumor capability and almost no obvious side effects 26 . A growing body of studies has shown that both Chinese herbs and their active components can directly inhibit tumors by inhibiting angiogenesis 27 , blocking the tumor cell growth cycle 28 - 30 , or inducing tumor cell apoptosis 31 , 32 and indirectly inhibit tumors by regulating the tumor microenvironment; for example, by increasing the activity of NK cells 33 , downregulating the immunosuppressive activity of myeloid-derived suppressor cells 28 , 34 , and improving the immune response of dendritic cells 35 . Our lab has been committed to revealing the mechanism of the antitumor activity of nature compounds for years 28 , 30 , 31 , 33 .…”

Section: Discussionmentioning

confidence: 99%

Alizarin, a nature compound, inhibits the growth of pancreatic cancer cells by abrogating NF-κB activation

Xu¹,

Hou²,

C³

et al. 2022

Int. J. Biol. Sci.

Self Cite

View full text Add to dashboard Cite

The current performance of nature compounds in antitumor field is gradually attracted more and more attention, we discovered a nature active ingredient alizarin possess potent natural reductive NF-κB activity to against pancreatic cancer. However, the preclinical pharmacology and therapeutic effect, and the underlying mechanisms of alizarin in inhibiting pancreatic cancer are still unclear. After high-throughput screening, this is the first report that alizarin can induce a potent inhibitory effect against pancreatic cancer cells. Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-α-stimulated NF-κB activity and nuclear translocation, and inactivated its related TNF-α-TAK1-NF-κB signaling cascade followed by downregulation of NF-κB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc). Due to the abrogation of NF-κB activity, combination of alizarin and gemcitabine exerted a better inhibitory effect on pancreatic cancer. In summary, natural component alizarin, inhibited cell proliferation and induced apoptosis in vitro and in vivo through targeting of the NF-κB signaling cascade with minimal toxicity, which combine with gemcitabine, can significantly enhance the antitumor capability, playing a synergistic effect. Therefore, alizarin may play a role in reversing gemcitabine resistance caused by overactivated NF-κB in clinical application in the future.

show abstract

Section: Discussionmentioning

confidence: 99%

Alizarin, a nature compound, inhibits the growth of pancreatic cancer cells by abrogating NF-κB activation

Xu¹,

Hou²,

C³

et al. 2022

Int. J. Biol. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…JHD decreased the content of ROS in MDSCs, inhibited CD4 + T cells proliferation and the percentages of Th17 and Treg, but elevated the proportion of CTLs and DCs to relieve the MDSCsmediated immunosuppressive state in HCC (37). Another research reported that Baoyuan Jiedu decoction (BYJD), a traditional Chinese medicine formula composed of Astragalus, Ginseng, Aconite root, Honeysuckle, Angelica, and Licorice, inhibited the TGF-b/CCL9 signaling pathway and reduced the number of MDSCs in peripheral blood and spleen of breast However, after G-MDSCs were completely depleted, the cytotoxicity of CD8 + T cells and the inhibitory effect of MDSCs had no significant difference between ZQT group and the control group, suggesting that the anti-tumor activity of ZQT was achieved by targeting G-MDSCs subset (39). Chinese medicine compounds also could decline the generation of MDSCs.…”

Section: Myeloid-derived Suppressor Cells (Mdscs)mentioning

confidence: 97%

“…Thoroughly discovered that ZQT suppressed the level of STAT3, p-STAT3 and anti-apoptotic protein Bcl-2, increased the expression of pro-apoptotic protein Bax, cleaved caspase-3 and PARP to induce the apoptosis of G-MDSCs in lung carcinoma in situ . However, after G-MDSCs were completely depleted, the cytotoxicity of CD8 + T cells and the inhibitory effect of MDSCs had no significant difference between ZQT group and the control group, suggesting that the anti-tumor activity of ZQT was achieved by targeting G-MDSCs subset ( 39 ). Chinese medicine compounds also could decline the generation of MDSCs.…”

Section: The Regulatory Effects Of Chinese Medicine Compounds On Innate Immune Cellsmentioning

confidence: 97%

Anti-Tumor Effects of Chinese Medicine Compounds by Regulating Immune Cells in Microenvironment

Chen

Wang

et al. 2021

Front. Oncol.

View full text Add to dashboard Cite

As the main cause of death in the world, cancer is one of the major health threats for humans. In recent years, traditional Chinese medicine has gained great attention in oncology due to the features of multi-targets, multi-pathways, and slight side effects. Moreover, lots of traditional Chinese medicine can exert immunomodulatory effects in vivo. In the tumor microenvironment, tumor cells, immune cells as well as other stromal cells often coexist. With the development of cancer, tumor cells proliferate uncontrollably, metastasize aggressively, and modulate the proportion and status of immune cells to debilitate the antitumor immunity. Reversal of immunosuppressive tumor microenvironment plays an essential role in cancer prevention and therapy. Immunotherapy has become the most promising strategy for cancer therapy. Chinese medicine compounds can stimulate the activation and function of immune cells, such as promoting the maturation of dendritic cells and inducing the differentiation of myeloid-derived suppressor cells to dendritic cells and macrophages. In the present review, we summarize and discuss the effects of Chinese medicine compounds on immune cells in the tumor microenvironment, including innate immune cells (dendritic cells, natural killer cells, macrophages, and myeloid-derived suppressor cells) and adaptive immune cells (CD4+/CD8+ T lymphocytes and regulatory T cells), and the various immunomodulatory roles of Chinese medicine compounds in cancer therapy such as improving tumor-derived inflammation, enhancing the immunity after surgery or chemotherapy, blocking the immune checkpoints, et al., aiming to provide more thoughts for the anti-tumor mechanisms and applications of Chinese medicine compounds in terms of tumor immunity.

show abstract

“…ZQT was found to induce G-MDSC apoptosis through the STAT3/S100A9/Bcl-2/caspase-3 signaling pathway, and it significantly reduced the number of MDSCs. ZQT was shown to remodel the immune tumor microenvironment by eliminating MDSCs and enriching T cells, prolonging survival and inhibiting tumor growth in a orthotopic mouse model of lung cancer [ 63 ].…”

Section: Effects Of Natural Products On the Tumor Microenvironmentmentioning

confidence: 99%

Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment

Yang

Wang

et al. 2021

IJMS

View full text Add to dashboard Cite

Lung cancer is one of the most prevalent malignancies worldwide. Despite the undeniable progress in lung cancer research made over the past decade, it is still the leading cause of cancer-related deaths and continues to challenge scientists and researchers engaged in searching for therapeutics and drugs. The tumor microenvironment (TME) is recognized as one of the major hallmarks of epithelial cancers, including the majority of lung cancers, and is associated with tumorigenesis, progression, invasion, and metastasis. Targeting of the TME has received increasing attention in recent years. Natural products have historically made substantial contributions to pharmacotherapy, especially for cancer. In this review, we emphasize the role of the TME and summarize the experimental proof demonstrating the antitumor effects and underlying mechanisms of natural products that target the TME. We also review the effects of natural products used in combination with anticancer agents. Moreover, we highlight nanotechnology and other materials used to enhance the effects of natural products. Overall, our hope is that this review of these natural products will encourage more thoughts and ideas on therapeutic development to benefit lung cancer patients.

show abstract

Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer

Cited by 13 publications

References 29 publications

Alizarin, a nature compound, inhibits the growth of pancreatic cancer cells by abrogating NF-κB activation

Alizarin, a nature compound, inhibits the growth of pancreatic cancer cells by abrogating NF-κB activation

Anti-Tumor Effects of Chinese Medicine Compounds by Regulating Immune Cells in Microenvironment

Natural Products with Activity against Lung Cancer: A Review Focusing on the Tumor Microenvironment

Contact Info

Product

Resources

About