Zebrafish as a model organism for rare diseases of nervous system

Derzhavina, Ksenia A.; Ilyin, Nikita P.; Seredinskaya, Maria V.; Nerush, Maria O.; Zakharchenko, Ksenia V.; Sorokin, Dmitry V.; Demin, Konstantin A.; Kalueff, Allan V.

doi:10.18705/2782-3806-2022-2-2-17-32

jour

2022

DOI: 10.18705/2782-3806-2022-2-2-17-32

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Zebrafish as a model organism for rare diseases of nervous system

Ksenia A. Derzhavina

Nikita P. Ilyin

Maria V. Seredinskaya

et al.

Abstract: Rare (orphan) diseases are an urgent unmet biomedical problem. Tremendous efforts and resources are expended for the search for cures for these diseases. Zebrafish can provide a powerful screening tool for novel orphan drugs, and may also deepen our mechanistic understanding of such rare pathological conditions. Here, we discuss various models of orphan diseases of the nervous system on zebrafish, and outline associated problems, limitations and prospects in the context of the development of personalized medic… Show more

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2023

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Cited by 3 publications

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Modeling Tauopathies in Zebrafish (Danio rerio)

Kotova,

Kolesnikova,

Kalueff

2023

J Evol Biochem Phys

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Modeling Tauopathies in Zebrafish (Danio rerio)

Kotova,

Kolesnikova,

Kalueff

2023

J Evol Biochem Phys

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Using Zebrafish in Preclinical Drug Studies: Challenges and Opportunities

Kalueff,

Kotova,

Ikrin

et al. 2023

Bezopasnost' i risk farmakoterapii

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Scientific relevance. Since fiscal and regulatory constraints substantially limit bioscreening in rodent models, a wider implementation of additional alternative models in preclinical studies of medicines is gaining momentum. These alternative models include aquatic vertebrates, such as zebrafish (Danio rerio).Aim. The study aimed to examine zebrafish models in terms of their performance in preclinical studies, their current uses, the challenges and opportunities in the field, and strategic directions for the development of preclinical testing in zebrafish.Discussion. Here, the authors summarise the key zebrafish tests that are currently used to assess a wide range of small molecules for their general and endocrine toxicity and effects on the survival of embryos and larvae. The review discusses the strengths and weaknesses of zebrafish models for preclinical testing of neurotropic agents. Additionally, the authors overview various methodological approaches to improving zebrafish toxicity testing. Overall, the use of zebrafish models is gradually becoming internationally established for laboratory testing of small molecules.Conclusions. A wider implementation of zebrafish models in pharmaceutical research and preclinical testing as an additional alternative to rodents, particularly in Russia, may significantly accelerate the development of novel medicinal products and foster a more comprehensive and adequate assessment of the biological risks associated with chemical substances.

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Modeling Taupathies in Zebrafish (<i>Danio rerio</i>)

Kotova,

Kolesnikova,

Kalueff

2023

Rossijskij fiziologičeskij žurnal im. I.M. Sečenova

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Taupathies are a group of neurodegenerative diseases characterized by the accumulation of tau-protein in the brain, causing clinical dementia. Tau protein stabilizes microtubules and regulates axonal transport, however, when hyper-phosphorylated, aggregates in the brain. Taupaties can be divided into primary and secondary (e.g., Alzheimer’s disease). Experimental animal models models are an important tool to study taupathies. Here, we discuss molecular mechanisms of taupathies and their existing experimental models in both rodents and novel alternative organisms, zebrafish (Danio rerio), as well as future novel directions of research in this field.

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Zebrafish as a model organism for rare diseases of nervous system

Cited by 3 publications

References 115 publications

Modeling Tauopathies in Zebrafish (Danio rerio)

Modeling Tauopathies in Zebrafish (Danio rerio)

Using Zebrafish in Preclinical Drug Studies: Challenges and Opportunities

Modeling Taupathies in Zebrafish (<i>Danio rerio</i>)

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