Zebrafish frizzled‐2 morphant displays defects in body axis elongation

Def6 Is Required for Convergent Extension Movements during Zebrafish Gastrulation Downstream of Wnt5b Signaling

“…Notably, at the 10-somite stage, expression of myoD in the two lines of adaxial cells was present in def6 morphants, although the two lines were not straight but curved due to the undulated notochord in-between the adaxial lines. In the posterior region of the somites, however, myoD expression was either expanded or absent (Figure 5N and O), strongly resembling Frizzled 2 morphants [28]. Taken together, these results indicate a requirement for def6 in the control of CE movements of axial, paraxial and neuroectodermal cells during the course of gastrulation.…”

Involvement of hepatocellular carcinoma biomarker, cyclase-associated protein 2 in zebrafish body development and cancer progression

“…This indicates that CAP2 plays an important conserved role in higher vertebrates, particularly in the development of skeletal muscle. We realized that almost all knockdowns of various genes in zebrafish affect body development [30][31][32], through skeletal muscle, somite, or neural formation defects, indicating that many genes or signaling pathways are involved in the patterning processes in a vertebrate embryo; here we showed the possible role of CAP2. Further, it would be interesting to investigate the mechanisms regulating CAP2 and CAP1 in developmental processes and in different organs.…”

Xenopus frizzled‐7 morphant displays defects in dorsoventral patterning and convergent extension movements during gastrulation

“…Although both Xfz7 and zebrafish fz2 appear to function during gastrulation, their downregulation results in quite different developmental defects. Whereas Xfz7 downregulation results in the direct inhibition of convergent extension movements, fz2 morphants apparently undergo defective convergent extension resulting in the undulating axial structures such as notochord, neural tube and hypochord (Sumanas et al, 2001). These results suggest that Fz7 and Fz2 are likely to regulate different aspects of convergent extension during gastrulation, although we cannot exclude possible species differences between Xenopus laevis and Danio rerio.…”

“…In the accompanying paper, we report a role for another Frizzled homolog, zebrafish frizzled-2, in body axis elongation (Sumanas et al, 2001). Zebrafish fz2 and Xfz7 are different homologs, according to sequence homology alignments and expression pattern comparisons.…”