2010
DOI: 10.1016/j.tox.2010.05.012
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Zebrafish teratogenicity test with metabolic activation (mDarT): Effects of phase I activation of acetaminophen on zebrafish Danio rerio embryos

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Cited by 57 publications
(37 citation statements)
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“…For this reason, an early focus in alternative method development was on tests for embryonic malformations (Augustine-Rauch et al, 2010). The most complete reflection of embryonic development apparently can be achieved with zebrafish embryos (Selderslaghs et al, 2011;Sukardi et al, 2011;Weigt et al, 2010Weigt et al, , 2011Yang et al, 2009), for example using dynamic cell imaging, or frog eggs (FETAX assay) (Hoke and Ankley, 2005), which has been evaluated more critically by IC-CVAM 1 . It seems to be timely to evaluate available protocols and datasets and define a protocol for formal validation.…”
Section: Reduction To Key Eventsmentioning
confidence: 99%
“…For this reason, an early focus in alternative method development was on tests for embryonic malformations (Augustine-Rauch et al, 2010). The most complete reflection of embryonic development apparently can be achieved with zebrafish embryos (Selderslaghs et al, 2011;Sukardi et al, 2011;Weigt et al, 2010Weigt et al, , 2011Yang et al, 2009), for example using dynamic cell imaging, or frog eggs (FETAX assay) (Hoke and Ankley, 2005), which has been evaluated more critically by IC-CVAM 1 . It seems to be timely to evaluate available protocols and datasets and define a protocol for formal validation.…”
Section: Reduction To Key Eventsmentioning
confidence: 99%
“…Numerous authors have conducted tests concerning the early development stages of zebra fish, all revealing an increased sensitivity of this test to estimate: the maximum acceptable concentration of a toxin [2][3][4][6][7][8], developmental neurotoxicity [24], teratogenicity [5,23], embryotoxicity [3,25], and/or screening a large number of chemicals [10,13,14,26].…”
Section: Discussionmentioning
confidence: 99%
“…Other researchers conducted tests on zebra fish embryos focusing especially on: pigmentation disorders, effects on heart rate, and teratogenicity of the chemicals, reaching the conclusion that these assays are very useful in the screening tests that can be used in preclinical trials [5,11,14,[25][26][27].…”
Section: Discussionmentioning
confidence: 99%
“…For each control and exposure group, the early embryonic development was observed by the TS100-F microscope and mortality was recorded at an interval of 24 h. After 72 h exposure experiments, mortality, hatching rate and malformation rate of embryos in each group were recorded. Similarly, five different dilution degrees were adopted [26]. …”
Section: Methodsmentioning
confidence: 99%