Zellvermittelte Immunreaktionen am Beispiel der rheumatoiden Arthritis

Abstract

Übersicht Internist 1999 · 40:930-935 © Springer-Verlag 1999

Folate receptor-targeting mesoporous silica-coated gold nanorod nanoparticles for the synergistic photothermal therapy and chemotherapy of rheumatoid arthritis

“…These surface antigens and mediators facilitate the progression of RA by mediating inammatory cell migration and neovascularization. 9,11,12 Second, synovial broblasts in RA might induce activated macrophages to differentiate into osteoclasts, causing severe cartilage damage. 13,14 Folate receptor b (FRb) is a receptor overexpressed on the surface of RA-activated macrophages, which could specically recognize and bind to a nanoscale drug delivery system modied with folic acid molecules (FA).…”