Zentrale Repr�sentation hustenwirksamer Afferenzen in der Medulla oblongata der Katze

Engelhorn, R.; Weller, E.

doi:10.1007/bf00362444

Cited by 21 publications

(9 citation statements)

References 11 publications

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“…MEDULLARY RESPIRATORY NETWORK AND COUGH menting patterns. These results are supported by earlier (15,21,22) and recent observations (20,37).…”

supporting

confidence: 91%

“…The question left unanswered was whether the cough motor pattern is produced by the same brain stem neurons that generate the normal respiratory rhythm or by a separate ''cough center.'' Engelhorn and Weller (15) and Jakus et al (21,22) reported that inspiratory-and expiratorymodulated neurons in the caudal lateral medulla and inspiratory neurons in the region of the nucleus tractus solitarii (NTS) increased firing rates during the appropriate phases of cough. These observations suggested the involvement of respiratory network neurons in cough.…”

mentioning

confidence: 99%

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Ventrolateral medullary respiratory network and a model of cough motor pattern generation

Shannon

Baekey

Morris

et al. 1998

Journal of Applied Physiology

149

174

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The primary hypothesis of this study was that the cough motor pattern is produced, at least in part, by the medullary respiratory neuronal network in response to inputs from "cough" and pulmonary stretch receptor relay neurons in the nucleus tractus solitarii. Computer simulations of a distributed network model with proposed connections from the nucleus tractus solitarii to ventrolateral medullary respiratory neurons produced coughlike inspiratory and expiratory motor patterns. Predicted responses of various "types" of neurons (I-DRIVER, I-AUG, I-DEC, E-AUG, and E-DEC) derived from the simulations were tested in vivo. Parallel and sequential responses of functionally characterized respiratory-modulated neurons were monitored during fictive cough in decerebrate, paralyzed, ventilated cats. Coughlike patterns in phrenic and lumbar nerves were elicited by mechanical stimulation of the intrathoracic trachea. Altered discharge patterns were measured in most types of respiratory neurons during fictive cough. The results supported many of the specific predictions of our cough generation model and suggested several revisions. The two main conclusions were as follows: 1) The Bötzinger/rostral ventral respiratory group neurons implicated in the generation of the eupneic pattern of breathing also participate in the configuration of the cough motor pattern. 2) This altered activity of Bötzinger/rostral ventral respiratory group neurons is transmitted to phrenic, intercostal, and abdominal motoneurons via the same bulbospinal neurons that provide descending drive during eupnea.

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“…MEDULLARY RESPIRATORY NETWORK AND COUGH menting patterns. These results are supported by earlier (15,21,22) and recent observations (20,37).…”

supporting

confidence: 91%

mentioning

confidence: 99%

Ventrolateral medullary respiratory network and a model of cough motor pattern generation

Shannon

Baekey

Morris

et al. 1998

Journal of Applied Physiology

149

174

View full text Add to dashboard Cite

show abstract

“…Studies on brainstem neuronal activity during coughing are not definitive in this respect [3][4][5][6][7]. The main studies on the neurophysiology of cough have been to define the afferent pathways, leaving the central nervous system as a black box.…”

Section: Control Nervous Mechanismsmentioning

confidence: 99%

Neurophysiology of the cough reflex

Jg¹

1995

Eur Respir J

343

197

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“…Weller (16,17) recorded the activity of expiratory neurons during coughs induced in anes thetized cats. They described that spikes of the expiratory neurons elicited by single shock to the SL nerve were abolished with 2 mg/ kg of codeine.…”

Section: Discussionmentioning

confidence: 99%

Effects of Antitussive Drugs on the Activity of the Recurrent Laryngeal Nerve in Cats

Mori¹,

Sakai²

1975

Jpn.J.Pharmacol

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Abstract-Reflex responses in the recurrent laryngeal (RL) nerve to stimulation of the superior laryngeal (SL) nerve and the effects of antitussive drugs on these reflex re sponses were studied in order to elucidate the site of action of these drugs in encephale isole cats. The RL nerve fibers were classified into four types by discharge patterns in respect to phases of artificial ventilation; type I: no spontaneous discharges, type II: discharges in phase with inflation of the lung, type III: discharges in phase with deflation of the lung, type IV: tonic discharges.Repetitive stimulation of the SL nerve elicited tonic burst discharges or short burst discharges in all types of RL nerve, while the same procedure inhibited ongoing discharges of the type III and IV fib: rs only. The inhibited fibers tended to have slow conduction velocities (20-80 m/sec). Administration of antitussive drugs such as codeine, dextro methorphan and oxymetebanol as well as pentobarbital decreased the frequency of the after spike dis chargesin the RL nerves evoked following repetitive shocks to the SL nerve, but had no effects on the inhibition of RL nerve discharges evoked by the stimulation of the same nerve. The neuropharmacological implication of these findings as related to the cough reflex are discussed.The special role of the glottis in the cough is well known (1). The glottis closes for a short time and then suddenly opens very early in the process of expiration. The activity in the recurrent laryngeal (RL) nerve either opens or closes the larynx through contraction of the corresponding musculatures (2, 3). Histological and physiological studies have shown that the ambigLius nucleus is the motor nucleus of the RL nerve (4, 5).In a previous report, a preliminary intracellular study of the ambiguus neurons was per formed and polysynaptic excitatory postsynatic potentials (EPSP) from the superior laryngeal (SL) nerve were recorded (6). However, the small size of the ambiguus motoneurons im peded the stable recording of the synaptic potentials responsible for the contraction of the glottis during repetitive stimulation of the SL nerve, thus making a quantitative assessment of the change during the time course of drug action almost impossible. Therefore, the present study was undertaken to obtain more information on the motoneurons by recording activity of the motor axons in the RL nerve which induce contraction of the laryngeal muscles and to ascertain the effects of certain antitussive drugs and pentobarbital on the RL nerve in cats.

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Zentrale Repr�sentation hustenwirksamer Afferenzen in der Medulla oblongata der Katze

Cited by 21 publications

References 11 publications

Ventrolateral medullary respiratory network and a model of cough motor pattern generation

Ventrolateral medullary respiratory network and a model of cough motor pattern generation

Neurophysiology of the cough reflex

Effects of Antitussive Drugs on the Activity of the Recurrent Laryngeal Nerve in Cats

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