Zeolites for theranostic applications

Yazdi, Mohsen Khodadadi; Zarrintaj, Payam; Hosseiniamoli, Hadi; Mashhadzadeh, Amin Hamed; Saeb, Mohammad Reza; Ramsey, Joshua D.; Ganjali, Mohammad Reza; Mozafari, Masoud

doi:10.1039/d0tb00719f

Cited by 53 publications

(11 citation statements)

References 154 publications

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“…Nowadays, zeolites have a wide range of industrial, environmental, and biomedical applications [ 1 , 2 , 3 , 4 , 5 ] and are available as both natural minerals and artificially produced materials. Of the over 40 natural and 230 synthetic zeolites known [ 4 , 6 ], many are subjected to diverse applications that harness the porous characteristic, ion exchange property, and high adsorption capacity of zeolites [ 3 , 4 , 6 ]. In addition, zeolites possess channels and/or cavities linked by channels, which give it a unique structural feature over other aluminosilicate and crystalline materials.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the special properties of zeolites have garnered much attention towards the material in biomedicine [ 4 , 6 ]. Naturally occurring zeolite clinoptilolite is the most widely used zeolite in various biomedical applications [ 7 ] and for environmental and alimentary decontamination from radioactivity and toxic substances, respectively [ 2 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review

Hao

Milašin²,

Eken

et al. 2021

Molecules

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Zeolites and zeolitic imidazolate frameworks (ZIFs) are widely studied as drug carrying nanoplatforms to enhance the specificity and efficacy of traditional anticancer drugs. At present, there is no other systematic review that assesses the potency of zeolites/ZIFs as anticancer drug carriers. Due to the porous nature and inherent pH-sensitive properties of zeolites/ZIFs, the compounds can entrap and selectively release anticancer drugs into the acidic tumor microenvironment. Therefore, it is valuable to provide a comprehensive overview of available evidence on the topic to identify the benefits of the compound as well as potential gaps in knowledge. The purpose of this study was to evaluate the potential therapeutic applications of zeolites/ZIFs as drug delivery systems delivering doxorubicin (DOX), 5-fluorouracil (5-FU), curcumin, cisplatin, and miR-34a. Following PRISMA guidelines, an exhaustive search of PubMed, Scopus, Embase, and Web of Science was conducted. No language or time limitations were used up to 25th August 2021. Only full text articles were selected that pertained to the usage of zeolites/ZIFs in delivering anticancer drugs. Initially, 1279 studies were identified, of which 572 duplicate records were excluded. After screening for the title, abstract, and full texts, 53 articles remained and were included in the qualitative synthesis. An Inter-Rater Reliability (IRR) test, which included a percent user agreement and reliability percent, was conducted for the 53 articles. The included studies suggest that anticancer drug-incorporated zeolites/ZIFs can be used as alternative treatment options to enhance the efficacy of cancer treatment by mitigating the drawbacks of drugs under conventional treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review

Hao

Milašin²,

Eken

et al. 2021

Molecules

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“…Intense absorption in the NIR region indicates that PDA-based nanomaterials can be utilized in photothermal therapy (PTT), especially for cancer treatment. It can also contribute to the structure of smart drug delivery and/or theranostic platform . A recent paper revealed that the light absorption properties and photothermal effect of PDA could be adjusted through embedding donor–acceptor pairs in the PDA structure in order for the band-gap energy to decline .…”

Section: Pda: Chemistry Properties and Utilization In Surface Modific...mentioning

confidence: 99%

Polydopamine Biomaterials for Skin Regeneration

Yazdi

Zare

Khodadadi

et al. 2022

ACS Biomater. Sci. Eng.

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Designing biomaterials capable of biomimicking wound healing and skin regeneration has been receiving increasing attention recently. Some biopolymers behave similarly to the extracellular matrix (ECM), supporting biointerfacial adhesion and intrinsic cellular interactions. Polydopamine (PDA) is a natural bioadhesive and bioactive polymer that endows high chemical versatility, making it an exciting candidate for a wide range of biomedical applications. Moreover, biomaterials based on PDA and its derivatives have near-infrared (NIR) absorption, excellent biocompatibility, intrinsic antioxidative activity, antibacterial activity, and cell affinity. PDA can regulate cell behavior by controlling signal transduction pathways. It governs the focal adhesion behavior of cells at the biomaterials interface. These features make melanin-like PDA a fascinating biomaterial for wound healing and skin regeneration. This paper overviews PDA-based biomaterials’ synthesis, properties, and interactions with biological entities. Furthermore, the utilization of PDA nano- and microstructures as a constituent of wound-dressing formulations is highlighted.

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“…The potential of zeolites in biomedicine relies on their high specific surface with substantial functional centres and tunable structures with different pore sizes that could accommodate a variety of drug structures. If the drug is retained by adsorption on the surface or encapsulation within the pores, a targeted release in the body can be accomplished [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?

Ranković

Jevremović

Ležaić

et al. 2023

JFB

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Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was employed for drug quantification. The effects of the tested compounds on cell viability were evaluated using in vitro methylthiazol-tetrazolium (MTT) colorimetric technique against human colorectal carcinoma (cell line HCT-116) and MRC-5 fibroblasts. Zeolite structure remained unchanged during homogeneous drug impregnation with achieved drug loadings in the 18–21 mg/g range. The highest drug release, in the µM concentration range, with favourable kinetics was established for zeolite-supported 9-aminoacridine. The acridine delivery via zeolite carrier is viewed in terms of solvation energy and zeolite adsorption sites. The cytotoxic effect of supported acridines on HCT-116 cells reveals that the zeolite carrier improves toxicity, while the highest efficiency is displayed by zeolite-impregnated 9-aminoacridine. The 9-aminoacridine delivery via zeolite carrier favours healthy tissue preservation while accompanying increased toxicity toward cancer cells. Cytotoxicity results are well correlated with theoretical modelling and release study, providing promising results for applicative purposes.

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Zeolites for theranostic applications

Abstract: Theranostic platforms bring about a revolution in disease management. During recent years, theranostic nanoparticles have been utilized for imaging and therapy simultaneously. Among different classes of biomaterials, zeolites have proven to be highly efficient for theranostic applications.

Cited by 53 publications

References 154 publications

Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review

Effects of Zeolite as a Drug Delivery System on Cancer Therapy: A Systematic Review

Polydopamine Biomaterials for Skin Regeneration

Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?

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