Zero is an important number

Response to Smith and Brogly et al. commentaries on Zedler et al.

“…We thank Dr Smith as well as Dr Brogly and colleagues for their thoughtful commentaries on our paper . Both experts highlight important considerations when assessing the scientific literature related to harms, particularly in an especially challenging population such as pregnant women with opioid use disorder.…”

“…We agree with Dr Smith that the newest extension to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines contains several essential elements to improve harms reporting in systematic reviews. This extension was published after submission of our manuscript for peer review and should be considered in future similar work focused on assessing harms of health interventions, including but not limited to pregnant women receiving opioid agonist medication‐assisted treatment.…”