1995
DOI: 10.1016/0168-3659(94)00085-9
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Zero-order release from biphasic polymer hydrogels

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Cited by 237 publications
(123 citation statements)
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“…Squared correlation coefficients (R 2 ) obtained with the Zero-order model was 0.9706. This model can be used to describe the drug release from several types of delivery systems such as matrix tablets for drugs with low solubility 32 and osmotic systems, where drug release would be directly proportional at time. First-order kinetics 33,34 gave a R 2 of 0.9815.…”
Section: X-rays Diffraction Profile Obtained From Naproxen (A) Empmentioning
confidence: 99%
“…Squared correlation coefficients (R 2 ) obtained with the Zero-order model was 0.9706. This model can be used to describe the drug release from several types of delivery systems such as matrix tablets for drugs with low solubility 32 and osmotic systems, where drug release would be directly proportional at time. First-order kinetics 33,34 gave a R 2 of 0.9815.…”
Section: X-rays Diffraction Profile Obtained From Naproxen (A) Empmentioning
confidence: 99%
“…A nonhomogeneous distribution of drug is accounted for in a drug-release model proposed by Varelas et al, but the polymer matrix does not erode. 28,29 In this model, isolated domains act as reservoirs from which drug diffuses through a polymer matrix. We have developed a model for erosion and drug release that accounts for microphase-separated domains that erode at different rates and for partitioning of encapsulated drugs within the phase-separated domains.…”
Section: Introductionmentioning
confidence: 99%
“…As reported (Varelas, Dicon, Stediner, 1995), these models fit hydrophilic matrix systems containing poorly watersoluble drugs. In addition, the value of the release exponent n in the Korsmeyer-Peppas model approached a value of one, which corresponds to a case II transport mechanism, where drug release is predominately controlled by polymer relaxation and erosion.…”
Section: Resultsmentioning
confidence: 99%