Zero valent zinc nanoparticles promote neuroglial cell proliferation: A biodegradable and conductive filler candidate for nerve regeneration

Sezer, Ümran Aydemir; Öztürk, Kevser; Aru, Başak; Demirel, Gülderen Yanıkkaya; Sezer, Serdar; Bozkurt, Mehmet Recep

doi:10.1007/s10856-016-5831-1

Cited by 25 publications

(13 citation statements)

References 39 publications

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“…In this picture, an interesting material, which needs to be pointed out is ZnO. In [99,100] zinc nanoparticles were proposed as biodegradable and conductive filler for nerve regeneration, and the resulting effect on the promotion of neuroglial cell proliferation suggest this material as a potential candidate for further future investigations.…”

Section: Discussionmentioning

confidence: 99%

“…In order to enhance neural tissue regeneration in electrical fields through conductive materials, like piezoelectric materials, zinc is a promising candidate in this field. This metal presents important properties like biodegradability (lower degradation rate than iron and magnesium (0.018-0.145 mm/year)), biocompatibility, suturability, non-toxic behavior and rapid healing capacity [99,100].…”

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confidence: 99%

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A Review on Biomaterials for 3D Conductive Scaffolds for Stimulating and Monitoring Cellular Activities

et al. 2019

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During the last years, scientific research in biotechnology has been reporting a considerable boost forward due to many advances marked in different technological areas. Researchers working in the field of regenerative medicine, mechanobiology and pharmacology have been constantly looking for non-invasive methods able to track tissue development, monitor biological processes and check effectiveness in treatments. The possibility to control cell cultures and quantify their products represents indeed one of the most promising and exciting hurdles. In this perspective, the use of conductive materials able to map cell activity in a three-dimensional environment represents the most interesting approach. The greatest potential of this strategy relies on the possibility to correlate measurable changes in electrical parameters with specific cell cycle events, without affecting their maturation process and considering a physiological-like setting. Up to now, several conductive materials has been identified and validated as possible solutions in scaffold development, but still few works have stressed the possibility to use conductive scaffolds for non-invasive electrical cell monitoring. In this picture, the main objective of this review was to define the state-of-the-art concerning conductive biomaterials to provide researchers with practical guidelines for developing specific applications addressing cell growth and differentiation monitoring. Therefore, a comprehensive review of all the available conductive biomaterials (polymers, carbon-based, and metals) was given in terms of their main electric characteristics and range of applications.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

A Review on Biomaterials for 3D Conductive Scaffolds for Stimulating and Monitoring Cellular Activities

et al. 2019

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“…Electroactive scaffolds can be fabricated from conductive materials or prepared by the addition of conductive fillers to create a composite. These conductive materials can be classified as: carbon-based [5,12,14,15], conductive polymers [1][2][3]6], and metallic-based [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Polycaprolactone–Polyaniline Electroactive Scaffolds for Bone Tissue Engineering

et al. 2020

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Electrostimulation and electroactive scaffolds can positively influence and guide cellular behaviour and thus has been garnering interest as a key tissue engineering strategy. The development of conducting polymers such as polyaniline enables the fabrication of conductive polymeric composite scaffolds. In this study, we report on the initial development of a polycaprolactone scaffold incorporating different weight loadings of a polyaniline microparticle filler. The scaffolds are fabricated using screw-assisted extrusion-based 3D printing and are characterised for their morphological, mechanical, conductivity, and preliminary biological properties. The conductivity of the polycaprolactone scaffolds increases with the inclusion of polyaniline. The in vitro cytocompatibility of the scaffolds was assessed using human adipose-derived stem cells to determine cell viability and proliferation up to 21 days. A cytotoxicity threshold was reached at 1% wt. polyaniline loading. Scaffolds with 0.1% wt. polyaniline showed suitable compressive strength (6.45 ± 0.16 MPa) and conductivity (2.46 ± 0.65 × 10−4 S/cm) for bone tissue engineering applications and demonstrated the highest cell viability at day 1 (88%) with cytocompatibility for up to 21 days in cell culture.

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“…Electrical stimulation can promote neurite extension and axonal regrowth. Conductive scaffolds have better electrical conductivity, biocompatibility and lipophilicity for cell adhesion 14, 15, 16. Among them, graphene is an extremely important nanomaterial due to its exceptional physical and chemical properties 17, 18.…”

Section: Introductionmentioning

confidence: 99%

3D Fabrication with Integration Molding of a Graphene Oxide/Polycaprolactone Nanoscaffold for Neurite Regeneration and Angiogenesis

et al. 2018

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Treating peripheral nerve injury faces major challenges and may benefit from bioactive scaffolds due to the limited autograft resources. Graphene oxide (GO) has emerged as a promising nanomaterial with excellent physical and chemical properties. GO has functional groups that confer biocompatibility that is better than that of graphene. Here, GO/polycaprolactone (PCL) nanoscaffolds are fabricated using an integration molding method. The nanoscaffolds exhibit many merits, including even GO nanoparticle distribution, macroporous structure, and strong mechanical support. Additionally, the process enables excellent quality control. In vitro studies confirm the advantages of the GO/PCL nanoscaffolds in terms of Schwann cell proliferation, viability, and attachment, as well as neural characteristics maintenance. This is the first study to evaluate the in vivo performance of GO‐based nanoscaffolds in this context. GO release and PCL biodegradation is analyzed after long‐term in vivo study. It is also found that the GO/PCL nerve guidance conduit could successfully repair a 15 mm sciatic nerve defect. The pro‐angiogenic characteristic of GO is evaluated in vivo using immunohistochemistry. In addition, the AKT‐endothelial nitric oxide synthase (eNOS)‐vascular endothelial growth factor (VEGF) signaling pathway might play a major role in the angiogenic process. These findings demonstrate that the GO/PCL nanoscaffold efficiently promotes functional and morphological recovery in peripheral nerve regeneration, indicating its promise for tissue engineering applications.

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Zero valent zinc nanoparticles promote neuroglial cell proliferation: A biodegradable and conductive filler candidate for nerve regeneration

Cited by 25 publications

References 39 publications

A Review on Biomaterials for 3D Conductive Scaffolds for Stimulating and Monitoring Cellular Activities

A Review on Biomaterials for 3D Conductive Scaffolds for Stimulating and Monitoring Cellular Activities

3D Printing of Polycaprolactone–Polyaniline Electroactive Scaffolds for Bone Tissue Engineering

3D Fabrication with Integration Molding of a Graphene Oxide/Polycaprolactone Nanoscaffold for Neurite Regeneration and Angiogenesis

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