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During the last years, scientific research in biotechnology has been reporting a considerable boost forward due to many advances marked in different technological areas. Researchers working in the field of regenerative medicine, mechanobiology and pharmacology have been constantly looking for non-invasive methods able to track tissue development, monitor biological processes and check effectiveness in treatments. The possibility to control cell cultures and quantify their products represents indeed one of the most promising and exciting hurdles. In this perspective, the use of conductive materials able to map cell activity in a three-dimensional environment represents the most interesting approach. The greatest potential of this strategy relies on the possibility to correlate measurable changes in electrical parameters with specific cell cycle events, without affecting their maturation process and considering a physiological-like setting. Up to now, several conductive materials has been identified and validated as possible solutions in scaffold development, but still few works have stressed the possibility to use conductive scaffolds for non-invasive electrical cell monitoring. In this picture, the main objective of this review was to define the state-of-the-art concerning conductive biomaterials to provide researchers with practical guidelines for developing specific applications addressing cell growth and differentiation monitoring. Therefore, a comprehensive review of all the available conductive biomaterials (polymers, carbon-based, and metals) was given in terms of their main electric characteristics and range of applications.

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Karachi is the largest city of Pakistan. The temperature change in Karachi is studied in this research by analyzing the time series data of mean maximum temperature (MMxT), mean minimum temperature (MMiT) and mean annual temperature (MAT) from 1947 to 2005 (59 years). Data is analyzed in three parts by running linear regression and by taking anomalies of all time periods: (a) whole period from 1947-2005; (b) phase one 1947-1975 and (c) phase two 1976-2005. During 1947 to 2005 MMxT has increased about 4.6 • C, MMiT has no change and MAT has increased 2.25 • C. During 1947-1975, MMxT increased 1.9 • C, in this period there is −1.3 • C decrease in MMiT and MAT has raised upto 0.3 • C. During 1976-2005, the MMxT, MMiT and MAT increased 2.7 • C, 1.2 • C and 1.95 • C, respectively. The analysis shows significantly the role of extreme vulnerability of MMxT in rising the temperature of Karachi than the MMiT.