Zika Virus

Masmejan, Sophie; Musso, Didier; Vouga, Manon; Pomar, Léo; Dashraath, Pradip; Stojanov, Miloš; Panchaud, Alice; Baud, David

doi:10.3390/pathogens9110898

Cited by 73 publications

(72 citation statements)

References 112 publications

(135 reference statements)

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“…Regarding pregnant travelers, we found no specific risk-related protocols for them when visiting an area where ZIKV is in active circulation. The risk of severe adverse pregnancy outcomes for prenatally exposed babies in these areas is estimated at 5% to 13% [ 14 , 15 , 16 , 17 ], with higher rates during the first trimester of pregnancy. However, more information is needed to establish robust recommendations for pregnant women wishing to travel to endemic areas.…”

Section: Discussionmentioning

confidence: 99%

“…These findings corroborate those of previous reports suggesting that the clinical course is typically mild in children [ 1 , 5 , 7 , 21 ]. Most pediatric patients only experience a rash [ 17 , 20 ], whereas in adults, complications such as Guillain-Barré syndrome are more frequent. The two cases of vector-borne ZIKV infection in the travelling children reported here were acquired in Thailand.…”

Section: Discussionmentioning

confidence: 99%

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Zika Virus Infection in Tourists Travelling to Thailand: Case Series Report

et al. 2020

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Thailand is a popular tourist destination where Zika virus (ZIKV) transmission is currently active. To our knowledge, there are no reports of ZIKV infection imported from Thailand and affecting children. Here, we describe the clinical and microbiological findings in three cases of vector-borne ZIKV infection: An 11-year-old boy, a 2-year-old girl, and her pregnant mother, this last case leading to the prenatal exposure of her second baby to ZIKV in the second trimester of pregnancy. All patients were diagnosed after traveling to Thailand between September 2019 and January 2020. No complications were detected in any patient at follow-up, and the prenatally exposed fetus showed no abnormalities during intensive antenatal health care monitoring. On postnatal study, there were no clinical signs or microbiological findings of mother-to-child ZIKV transmission. ZIKV IgG was initially positive, but seroreversion occurred at 4 months of life. This report describes the clinical and serological evolution of vector-borne ZIKV infection occurring in dengue-naïve tourists returning from Thailand. The World Health Organization currently recommends that pre-travel advice to prevent arbovirus infection should be maintained in travelers to Southeast Asia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Zika Virus Infection in Tourists Travelling to Thailand: Case Series Report

et al. 2020

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“…According to a World Health Organization (WHO) report, as of July 2019, a total of 87 countries and territories had cases of infection [ 2 ]. Fever, rash, arthralgia and conjunctivitis are the main clinical symptoms, and the disease rarely causes death in adults, but it can cause a high risk of Congenital Zika Syndrome (CZS, a combination of severe neurological anomalies) in newborn babies after infection of pregnant women [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

An inactivated recombinant rabies virus displaying the Zika virus prM-E induces protective immunity against both pathogens

et al. 2021

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The global spread of Zika virus (ZIKV), which caused a pandemic associated with Congenital Zika Syndrome and neuropathology in newborns and adults, prompted the pursuit of a safe and effective vaccine. Here, three kinds of recombinant rabies virus (RABV) encoding the prM-E protein of ZIKV were constructed: ZI-D (prM-E), ZI-E (transmembrane domain (TM) of prM-E replaced with RABV G) and ZI-F (signal peptide and TM domain of prM-E replaced with the region of RABV G). When the TM of prM-E was replaced with the region of RABV G (termed ZI-E), it promoted ZIKV E protein localization on the cell membrane and assembly on recombinant viruses. In addition, the change in the signal peptide with RABV G (termed ZI-F) was not conducive to foreign protein expression. The immunogenicity of recombinant viruses mixed with a complex adjuvant of ISA 201 VG and poly(I:C) was tested in BALB/c mice. After immunization with ZI-E, the anti-ZIKV IgG antibody lasted for at least 10 weeks. The titers of neutralizing antibodies (NAbs) against ZIKV and RABV at week 6 were all greater than the protective titers. Moreover, ZI-E stimulated the proliferation of splenic lymphocytes and promoted the secretion of cytokines. It also promoted the production of central memory T cells (TCMs) among CD4+/CD8+ T cells and stimulated B cell activation and maturation. These results indicate that ZI-E could induce ZIKV-specific humoral and cellular immune responses, which have the potential to be developed into a promising vaccine for protection against both ZIKV and RABV infections.

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“…Since the beginning of the ZIKV pandemic, thousands of cases presenting ZIKV symptoms have been documented [8]. The virus causes an acute febrile illness and is characterized by mild headache, fever, maculopapular rash, joint and back pain, and general malaise, sometimes accompanied by conjunctival hyperemia, anorexia, dizziness, diarrhea, and constipation [8]. The incubation period is between 3 and 12 days and symptoms may last for 2 and 7 days.…”

Section: Introductionmentioning

confidence: 99%

“…The incubation period is between 3 and 12 days and symptoms may last for 2 and 7 days. Only ~20% of presenting patients infected with ZIKV exhibit symptoms and the virus has never been reported to cause hemorrhagic fever or death, often resulting in misdiagnosis as dengue [7][8][9]. Due to still unexplainable reasons the number of cases with ZIKV has precipitously declined in recent years in highly affected countries [10].…”

Section: Introductionmentioning

confidence: 99%

Differential expression of miRNAs in a human developing neuronal cell line chronically infected with Zika virus

Bagasra

Shamabadi

Pandey

et al. 2021

Libyan Journal of Medicine

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Zika virus (ZIKV) is a serious public health concern that may lead to neurological disorders in affected individuals. The virus can be transmitted from an infected mother to her fetus, via mosquitoes, or sexually. ZIKV infections are associated with increased risk for Guillain-Barré syndrome (GBS) and congenital microcephaly in newborns infected prenatally. Dysregulations of intracellular microRNAs (miRNAs) in infected neurons have been linked to different neurological diseases. To determine the potential role of miRNAs in ZIKV infection we developed a chronically infected neuroblastoma cell line and carried out differential expression analyses of miRNAs with reference to an uninfected neuroblastoma cell line. A total of 3192miRNAs were evaluated and 389 were found to be upregulated < 2-fold and 1291 were downregulated < 2-fold. In particular, we determined that hsa-mir- 431-5p, hsa-mir-3687, hsamir-4655-5p, hsa-mir-6071, hsa-mir-762, hsa-mir-5787, and hsa-mir-6825-3p were significantly downregulated, ranging from -5711 to -660-fold whereas, has- mir-4315, hsa-mir-5681b, hsamir-6511a-3p, hsa-mir-1264, hsa-mir-4418, hsa-mir-4497, hsa-mir-4485-3p, hsa-mir-4715-3p, hsamir-4433-3p, hsa-mir-4708-3p, hsa-mir-1973 and hsa-mir-564 were upregulated, ranging from 20-0.8-fold. We carried out target gene alignment of these miRNAs with the ZIKV genome to predict the function of the differentially expressed miRNAs and their potential impact on ZIKV pathogenesis. These miRNAs might prove useful as novel diagnostic or therapeutic markers and targets for further research on ZIKV infection and neuronal injury resulting from ZIKV infectivity in developing fetal brain neurons.

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Zika Virus

Cited by 73 publications

References 112 publications

Zika Virus Infection in Tourists Travelling to Thailand: Case Series Report

Zika Virus Infection in Tourists Travelling to Thailand: Case Series Report

An inactivated recombinant rabies virus displaying the Zika virus prM-E induces protective immunity against both pathogens

Differential expression of miRNAs in a human developing neuronal cell line chronically infected with Zika virus

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