Zika virus—a review for clinicians

Mo, Yin; Salada, Brenda Mae; Tambyah, Paul Anantharajah

doi:10.1093/bmb/ldw023

Cited by 18 publications

(15 citation statements)

References 70 publications

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“…Through the years, sporadic cases have been documented across Africa, Australia/Oceania, South America and Asia. (8) The recent surge in the number of cases of active local transmission of the Southeast Asian ZIKV strain in Singapore suggests an increase in the occurrence of factors such as El Niño weather conditions, (9) which can promote transmission of locally present ZIKV. It is also highly likely that a subset of the Singapore population may be immune to ZIKV.…”

Section: A Brief History Of the Zika Virusmentioning

confidence: 99%

A review of Zika virus infections in pregnancy and implications for antenatal care in Singapore

Lin

Tambyah

Yong

et al. 2017

smedj

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Given the consensus that there is a causal relationship between Zika virus (ZIKV) infection in pregnancy and congenital Zika syndrome (CZS), clinicians must be prepared to manage affected patients despite the numerous gaps in current knowledge. The clinical course in pregnancy appears similar to that in non-pregnant women, although viraemia may be prolonged. ZIKV infection can be diagnosed by serum and urine reverse transcription-polymerase chain reaction, but commercially available serological tests are currently unreliable in dengue-endemic regions. Although vertical transmission can occur at any time during gestation, first-and second-trimester infections have the highest risk of developing central nervous system anomalies. Aberrant fetal growth and pregnancy loss may also occur. Serial ultrasonography should be conducted for infected cases. Without a vaccine, pregnant women should be advised to minimise mosquito bites and reduce sexual transmission risk. Overall, the absolute risk of CZS arising amid a ZIKV outbreak appears relatively low.

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Section: A Brief History Of the Zika Virusmentioning

confidence: 99%

A review of Zika virus infections in pregnancy and implications for antenatal care in Singapore

Lin

Tambyah

Yong

et al. 2017

smedj

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“…[1][2][3] Although understanding of the natural history and spectrum of Zika virus infections is incomplete, the acute illness can range from mild to severe, and chronic complications affect physical and mental domains with lifelong implications. [4][5][6] The virus is transmitted both indirectly (via vector, blood transfusion, or organ transplant) or directly (via sexual or mother-to-child transmission). 1,3,7 In the Americas, Zika virus could have been introduced as early as 2013.…”

Section: Introductionmentioning

confidence: 99%

Infection-related microcephaly after the 2015 and 2016 Zika virus outbreaks in Brazil: a surveillance-based analysis

et al. 2017

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“…Zika is a zoonotic disease that is now being efficiently transmitted between humans; however, it was first isolated from rhesus monkeys in Uganda in 1947. (10) Although there is no evidence that non-human primates are involved in the spread of the Zika virus, (11) it may be speculated that due to the close relation between the cynomolgus and rhesus monkeys, the virus could also possibly infect cynomolgus monkeys via mosquitoes. (12) However, to date, there are no studies that support this claim.…”

mentioning

confidence: 99%