Zika Virus Disease in Traveler Returning from Vietnam to Israel

Meltzer, Eyal; Lustig, Yaniv; Leshem, Eyal; Levy, Ran; Gottesman, Giora; Weissmann, Rotem; Rabi, Duha Hejleh; Hindiyeh, Musa; Koren, Ravit; Mendelson, Ella; Schwartz, Eli

doi:10.3201/eid2208.160480

Cited by 46 publications

(50 citation statements)

References 6 publications

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“…Results showed Zika virus RNA sequences with high similarity to those of strains identified in the likely geographical areas of infection (Asian lineage) [6]. Unfortunately, we were not able to isolate and grow infectious virus in tissue culture.…”

Section: Zika Virus Rna In Serum Urine and Whole Bloodmentioning

confidence: 90%

“…For sequencing of Zika RNA, a 327 fragment from the prM and ENV genes was amplified by reverse-transcription PCR using primers ZIKV 835 (5'-TTGGTCATGATACTGCTGATTGC-3') and ZIKV 1162c (5'-CCACTAACGTTCTTTTGCAGACAT-3') [8] and sequenced on an ABI 3500 Genetic Analyzer (Applied Biosystems, Foster City, CA, United States) using an ABI PRISM BigDye Terminator Cycle Sequencing kit (Applied Biosystems) [6].…”

Section: Laboratory Investigationsmentioning

confidence: 99%

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Detection of Zika virus RNA in whole blood of imported Zika virus disease cases up to 2 months after symptom onset, Israel, December 2015 to April 2016

et al. 2016

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Section: Zika Virus Rna In Serum Urine and Whole Bloodmentioning

confidence: 90%

Section: Laboratory Investigationsmentioning

confidence: 99%

Detection of Zika virus RNA in whole blood of imported Zika virus disease cases up to 2 months after symptom onset, Israel, December 2015 to April 2016

et al. 2016

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“…Diagnosis of all Zika patients was performed in their resident country either by detection of ZIKV RNA in whole blood, urine, semen, or serum samples (18 patients) (4), by neutralization assay (26 patients), or by both Zika RNA detection and neutralization (19 patients) ( Table 1). Some of the positive PCR patients were also sequenced (8). All samples from Zika-positive patients were subjected to Zika NS1-based ELISA in the patient's resident country.…”

Section: Resultsmentioning

confidence: 99%

Sensitivity and Kinetics of an NS1-Based Zika Virus Enzyme-Linked Immunosorbent Assay in Zika Virus-Infected Travelers from Israel, the Czech Republic, Italy, Belgium, Germany, and Chile

et al. 2017

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Serological diagnosis of Zika virus is challenging due to high crossreactivity of Zika virus with other flavivirus antibodies. Recently, a Zika NS1-based enzyme-linked immunosorbent assay (ELISA) was developed and shown to be highly specific for Zika antibody detection; however, sensitivity was evaluated for only a small number of confirmed Zika-infected patients. In this study, we measured the sensitivity and kinetics of Zika IgM and IgG antibodies using the Zika NS1-based ELISA in 105 samples from 63 returning travelers infected with Zika virus (proven by PCR or neutralization assay) from Israel, Czech Republic, Italy, Belgium, Germany, and Chile. Zika virus IgM was detected from 2 to 42 days post-symptom onset (PSO) with an overall sensitivity of 79% in the first month and 68% until 2 months PSO, while IgG antibodies were detected from 5 days to 3 years PSO with 79% sensitivity. Interestingly, significant differences in IgM sensitivity and IgM detection period were observed between Israeli and European/Chilean Zika-infected travelers, adding to the complexity of Zika infection diagnosis and suggesting that other diagnostic methods should be complemented to reduce false-negative results.

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“…In particular, evidence for the long-standing presence of ZIKV in Southeast Asia comes from indirect serological evidence in non-acute samples from Thailand, (4) Malaysia, (5) Indonesia (6) and Vietnam (7) between the 1950s and 1970s. Through the years, sporadic cases have been documented across Africa, Australia/Oceania, South America and Asia.…”

Section: A Brief History Of the Zika Virusmentioning

confidence: 99%

A review of Zika virus infections in pregnancy and implications for antenatal care in Singapore

Lin

Tambyah

Yong

et al. 2017

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Given the consensus that there is a causal relationship between Zika virus (ZIKV) infection in pregnancy and congenital Zika syndrome (CZS), clinicians must be prepared to manage affected patients despite the numerous gaps in current knowledge. The clinical course in pregnancy appears similar to that in non-pregnant women, although viraemia may be prolonged. ZIKV infection can be diagnosed by serum and urine reverse transcription-polymerase chain reaction, but commercially available serological tests are currently unreliable in dengue-endemic regions. Although vertical transmission can occur at any time during gestation, first-and second-trimester infections have the highest risk of developing central nervous system anomalies. Aberrant fetal growth and pregnancy loss may also occur. Serial ultrasonography should be conducted for infected cases. Without a vaccine, pregnant women should be advised to minimise mosquito bites and reduce sexual transmission risk. Overall, the absolute risk of CZS arising amid a ZIKV outbreak appears relatively low.

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Zika Virus Disease in Traveler Returning from Vietnam to Israel

Cited by 46 publications

References 6 publications

Detection of Zika virus RNA in whole blood of imported Zika virus disease cases up to 2 months after symptom onset, Israel, December 2015 to April 2016

Detection of Zika virus RNA in whole blood of imported Zika virus disease cases up to 2 months after symptom onset, Israel, December 2015 to April 2016

Sensitivity and Kinetics of an NS1-Based Zika Virus Enzyme-Linked Immunosorbent Assay in Zika Virus-Infected Travelers from Israel, the Czech Republic, Italy, Belgium, Germany, and Chile

A review of Zika virus infections in pregnancy and implications for antenatal care in Singapore

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