Zika Virus Infection during Pregnancy and Congenital Abnormalities

Rather, Irfan A.; Lone, Jameel; Bajpai, Vivek K.; Park, Yong-Ha

doi:10.3389/fmicb.2017.00581

Cited by 31 publications

(25 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, anomalies to the brains of the fetuses were detected, ranging from white matter hypoplasia to pathology to optic nerve and eyes. Similarly as seen in humans, detrimental effects were more evident when infection occurred in early pregnancy 96,97 .…”

Section: Protection In Pregnancymentioning

confidence: 53%

Zika virus vaccines

2018

View full text Add to dashboard Cite

The recent epidemic of Zika virus (ZIKV) in the Americas has revealed the devastating consequences of ZIKV infection, particularly in pregnant women. Congenital Zika syndrome, characterized by malformations and microcephaly in neonates as well as developmental challenges in children, highlights the need for the development of a safe and effective vaccine. Multiple vaccine candidates have been developed and have shown promising results in both animal models and phase I clinical trials. However, important challenges remain for clinical development of these vaccines. In this Progress, we discuss recent preclinical studies and lessons learned from first in-human clinical trials with ZIKV vaccines.

show abstract

Section: Protection In Pregnancymentioning

confidence: 53%

Zika virus vaccines

2018

View full text Add to dashboard Cite

show abstract

“…The initial discoveries of the virus were identified from pregnant brazilian women whose amniotic fluid tested positive for the Zikv and were later established in the fetuses which further confirmed the possible relationship between the Zikv and the causes of microcephaly [18][19][20].…”

Section: Olivar C Castejónmentioning

confidence: 71%

Zika Virus in Placental Villi at 28 Weeks of Pregnancy

Castejón¹,

Rondón²

2018

J Emerg Rare Dis

View full text Add to dashboard Cite

The aim of this study was to examine the structure of the placental villi associated with Zika virus at 28 weeks of pregnancy without another antecedent of illness and to be evaluated with light microscopy. Two groups of population of placental villi were taken of placenta study and placenta normal. The group studies proceed of placenta obtained at 37 weeks by caesarian delivery with fetal suffering. The placenta normal was obtained at 38 weeks with an increase of weight of woman pregnancy of 10 Kg both being processed according to previous works realized. The decidual region and stem villi showed infiltration of mononuclear cells. Stem villi were observed with thrombotic vessels, fibrinoid deposition, vascular obliteration, throphoblast necrosis and fibrosis. Zones of immature intermediate villi were seen suffering degenerative changes. Clear zones appeared in the stromal region of the placental villi. Mature intermediate villi have not bends and are absent of terminal villi. Numerous syncytial nodules are showed in zones of microinfarcts. Bad development of the ramifications of the placental villi is noted. These results indicate a destructive and generalized effect on the structure of the placental tree as also it has been affected by others viruses which damage the placenta contributing with fetal suffering or fetal death.

show abstract

“…Infections with DENV can evolve to hemorrhagic syndrome accompanied of hypovolemic shock, systemic failure and death, mainly in children. In turn, ZIKV infections when acquired during pregnancy, are associated with the occurrence of microcephaly and other neurological severe injuries in the fetus brain (Rather et al 2017). In adults, ZIKV has been associated with the occurrence of Guillan-Barré syndrome which is highly disabling (Song et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

The dengue virus non-structural protein 1 (NS1) use the scavenger receptor B1 as cell receptor in human hepatic and mosquito cells

Alcalá

Maravillas

Meza

et al. 2019

Preprint

View full text Add to dashboard Cite

15Dengue is the most common virus disease transmitted to humans by 16 mosquitoes. The dengue virus NS1 is a multifunctional protein that form part of 17 replication complexes. In addition, NS1 is also secreted, as a hexamer, to the 18 extracellular milieu. Circulating NS1 has been associated with dengue 19 pathogenesis by several different mechanisms. Cell binding and internalization 20 of soluble NS1 result in the disruption of tight junctions and in down regulation 21 of the innate immune response. In this work, we report that the HDL scavenger 22 receptor B1 (SRB1) in human hepatic cells, and a scavenger receptor B1-like in 23 mosquito C6/36 cells act as cell surface binding receptor for dengue virus NS1. 24 The presence of the SRB1 on the plasma membrane of C6/36 cells, as well as 25 in Huh-7 cells, was demonstrated by confocal microcopy. Internalization of NS1 26 can be efficiently blocked by anti-SRB1 antibodies and previous incubation of 27 the cells with HDL significantly reduces NS1 internalization. In addition, the 28 transient expression of SRB1 in Vero cells, which lack the receptor, renders 29 these cells susceptible to NS1 entry. Direct interaction between soluble NS1 30 and the SRB1 in Huh7 and C6/36 cells was demonstrated in vivo by proximity 31 ligation assays an in vitro by surface plasmon resonance. Finally, data is 32 presented indicating that the SRB1 also act as cell receptor for zika virus NS1. 33 These results demonstrate that dengue virus NS1, a bonna fide lipoprotein, 34 usurps the HDL receptor for cell entry and offers explanations for the altered 35 serum lipoprotein homeostasis observed in dengue patients.36 37 Key words: dengue, dengue virus, zika virus, NS1, scavenger receptor B-1. 38 39 The Flavivirus genus, belonging to the Flaviviridae family, includes a group of 40 vector borne viruses of importance in human public health as dengue virus 41 (DENV), Zika virus (ZIKV), yellow fever virus (YFV), Japanese encephalitis virus 42 (JEV) and West Nile virus (WNV). DENV and ZIKV are transmitted by the same 43 arthropods of the Aedes genus and share a similar geographical distribution 44 (Paixão et al 2018). It is estimated that almost half of the world population, 45 distributed in tropical and subtropical zones, is at risk of contracting these 46 diseases (WHO, 2018). The initial symptoms of both DENV and ZIKV infections 47 manifest as a febrile syndrome. Infections with DENV can evolve to 48 hemorrhagic syndrome accompanied of hypovolemic shock, systemic failure 49 and death, mainly in children. In turn, ZIKV infections when acquired during 50 pregnancy, are associated with the occurrence of microcephaly and other 51 neurological severe injuries in the fetus brain (Rather et al 2017). In adults, 52 ZIKV has been associated with the occurrence of Guillan-Barré syndrome which 53 is highly disabling (Song et al., 2017). DENV and ZIKV virions are spherical 54 particles of about 50nm in diameter. The positive RNA genome is about 11Kb in 55 length encoding for 3 structural (Membra...

show abstract

Zika Virus Infection during Pregnancy and Congenital Abnormalities

Cited by 31 publications

References 42 publications

Zika virus vaccines

Zika virus vaccines

Zika Virus in Placental Villi at 28 Weeks of Pregnancy

The dengue virus non-structural protein 1 (NS1) use the scavenger receptor B1 as cell receptor in human hepatic and mosquito cells

Contact Info

Product

Resources

About