This article shows how neoliberal deregulation, speculation, and financialization unleashed the unfathomable potential of global media, thereby disrupting prior assumptions about the scope, scale, and practices of media industries. After almost a century of American hegemony, the topographies of media industries are today growing more plastic and complicated as media institutions scale their ambitions and operations in an increasingly porous and dynamic environment. This article critically examines the features of US hegemony, the forces that are undermining it, and the emergence of a post-American era that is ineluctably global.