Zinc alginate-carboxymethyl cashew gum microbeads for prolonged drug release: Development and optimization

Das, B. Krishna; Dutta, Sukrit; Nayak, Amit Kumar; Nanda, Upendranath

doi:10.1016/j.ijbiomac.2014.07.030

Cited by 116 publications

(12 citation statements)

References 33 publications

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“…However, their stability in simulated wound exudate fluid or phosphate buffered saline (PBS) was relatively low since the ion exchange of Ca 2+ ions with PO 4 3− ions presented in the PBS occurred and there is no crosslinking reaction between HC and Ca 2+ ion. It was reported that Zn 2+ ion is one of metal ions that easily form complex with both chitosan derivatives and SA . Moreover, it is well known that Zn 2+ ion exhibited higher antibacterial activity than Ca 2+ ion .…”

Section: Introductionmentioning

confidence: 99%

Crosslinker Effects on Properties of Hydroxyethylacryl Chitosan/Sodium Alginate Hydrogel Films

Treenate

Monvisade

2017

Macromolecular Symposia

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Summary The aim of this research is to investigate the effects of Ca2+ and Zn2+ ions on the swelling behavior, mechanical property and antibacterial activity of hydroxyethylacryl chitosan (HC)/ sodium alginate (SA) hydrogel films. The hydrogel films composed of HC and SA in different proportions (75:25, 50:50 and 25:75 w/w) were prepared by dipping method using calcium chloride as a single crosslinking agent and both calcium chloride and zinc sulfate as a couple crosslinking agent. The structures of the films were characterized by infrared spectroscopy (FT‐IR). It was found that Ca2+ ions could only crosslink with SA through the formation of ionic bonds while Zn2+ ions could crosslink both HC through the formation of coordinate bonds and SA through the formation of partially ionic or coordinate bonds. The swelling behaviors of the films in phosphate buffered saline (PBS) were investigated. The results showed relatively high stability for the crosslinked films with the couple crosslinking agent. The mechanical properties of the hydrogel films were also tested. It was found that the mechanical properties of the calcium‐zinc crosslinked films were greater than calcium crosslinked films. The values of tensile strength and elongation at break of the calcium‐zinc crosslinked films in the fully hydrated state were up to 12.9 MPa and 67%, respectively. Additionally, the calcium‐zinc crosslinked films evidenced better antibacterial activity to Staphylococcus aureus than calcium crosslinked films. Moreover, all of prepared hydrogel films exhibited no cytotoxicity for Vero cells. The comprehensive results suggest their potential as a wound dressing.

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Section: Introductionmentioning

confidence: 99%

Crosslinker Effects on Properties of Hydroxyethylacryl Chitosan/Sodium Alginate Hydrogel Films

Treenate

Monvisade

2017

Macromolecular Symposia

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“…The drug release data were fitted into a variety of kinetic models like ( Q = k 0 t + Q 0 ), first‐order ( Q = Q 0 e k 1 t ), Higuchi ( Q = k H t 1 / 2 ), Hixson–Crowell ( Q 1 / 3 = k HC t + Q 0 1 / 3 ), and Korsmeyer–Peppas ( Q = k KP t n ) equations, where Q and Q 0 symbolize the amount of drug eluting at time t and zero, respectively; k 0 , k 1 , k H , k HC , and k KP designate the release rate constants and n represents the release exponent, implying drug release mechanism . When n is ≤ 0.43, the Fickian diffusion phenomenon dominates.…”

Section: Methodsmentioning

confidence: 99%

Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn⁺²‐Pectinate Controlled‐Release Matrices

et al. 2017

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The current study is aimed at developing Plantago ovata F. husk mucilage (PHM)‐blended Zn2+‐crosslinked low methoxyl (LM) pectinate (PHM‐Zn2+‐LM‐pectinate) controlled‐release matrices containing aceclofenac (ACF) for the management of rheumatoid arthritis (RA) in patients with an outright zinc deficiency. The ACF‐encapsulated hydrogel matrices are accomplished by ionic gelation using ZnSO4 as a crosslinker. The matrix diameter ranges from 1.39 ± 0.14 to 1.62 ± 0.16 mm. These formulations demonstrate excellent drug encapsulation efficiency (DEE, 63.80 ± 1.73–90.56 ± 2.72%) and controlled drug‐release behavior over a prolonged period of time (Q10 h, 51.42 ± 3.10 to 92.60 ± 2.38%). The drug‐elution patterns of different matrices are best‐fitted by a zero‐order kinetic model with a case‐II‐transport‐driven mechanism. The matrices also depict pH‐dependent swelling and degradation properties. In addition, the composites are characterized by scanning electron microscopy (SEM), Fourier transform IR (FTIR), and powder X‐ray diffraction (P‐XRD) analyses. Thus, the newly developed PHM‐Zn+2‐LM‐pectinate matrices could be appropriate for controlled ACF delivery along with Zn supplementation in the effective treatment of RA.

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“…2 represents schematic representation of the mechanism of uptake of NPs on oral administration. The direct uptake of NPs through the lymph into the systemic circulation by passing the liver reduces the first pass metabolism, thus improving bioavailability 12 .…”

Section: Channels Of Uptakementioning

confidence: 99%

“…Antibody coated particles accumulated in thrice the amount in PPs as compared to uncoated ones. The concept of site specificity for mucoadhesion based on the affinity between sugars and lectins has also been intensively investigated 12 . Wheat germ agglutinin (WGA) from Triticum vulgare specifically binds to N-acetyl-D glucosamine and sialic acid, both of which are constituents of mucus.…”

Section: Bioadhesionmentioning

confidence: 99%

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2017

IJPSR

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Peptide drugs are poorly absorbable and are also susceptible to enzymatic degradation in the gastrointestinal tract (GIT). To overcome the physiological and morphological barriers for the peptide / poorly absorbable drug delivery, mucopenetrative and mucoadhesive properties of drug carriers have to be considered. Mucoadhesion can prolong the residence time of drug carriers at the absorption sites, improved drug absorption and controlled release of drug from the device used. The particles with smaller size were likely to diffuse much faster into the mucus layer, provided that diffusion of the particles into the mucus layer should obey Stokes-Einstein equation. The adhesiveness of the nanoparticles (NPs) in suspension form helps to improve bioavailability. Chitosan (CS) based or CS-coated NPs represent another common group of mucoadhesive systems. Moreover, NPs made of such polymers were used to enhance the bioavailability, and also the mucoadhesion of proteins, peptides and DNA to the mucosal tissues. This review focuses on the mechanism of gastrointestinal mucoadhesion of NPs for peptide/poorly absorbable drugs.

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Zinc alginate-carboxymethyl cashew gum microbeads for prolonged drug release: Development and optimization

Cited by 116 publications

References 33 publications

Crosslinker Effects on Properties of Hydroxyethylacryl Chitosan/Sodium Alginate Hydrogel Films

Crosslinker Effects on Properties of Hydroxyethylacryl Chitosan/Sodium Alginate Hydrogel Films

Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn⁺²‐Pectinate Controlled‐Release Matrices

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Zinc alginate-carboxymethyl cashew gum microbeads for prolonged drug release: Development and optimization

Cited by 116 publications

References 33 publications

Crosslinker Effects on Properties of Hydroxyethylacryl Chitosan/Sodium Alginate Hydrogel Films

Crosslinker Effects on Properties of Hydroxyethylacryl Chitosan/Sodium Alginate Hydrogel Films

Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn+2‐Pectinate Controlled‐Release Matrices

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Aceclofenac‐Loaded Plantago ovata F. Husk Mucilage‐Zn⁺²‐Pectinate Controlled‐Release Matrices