Zinc and Central Nervous System Disorders

Wang, Bangqi; Fang, Tianshu; Chen, Zhidong

doi:10.3390/nu15092140

Cited by 22 publications

(8 citation statements)

References 262 publications

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“…Our findings of cognitive improvement are corroborated by previous studies that have shown neuroprotective properties, anti-inflammatory, and antioxidant effects of Zn [35,36]. The imbalance in zinc ion (Zn 2+ ) levels appears to play a crucial role in the etiology and progression of neurodegenerative diseases [5], such as Alzheimer's disease (AD), Parkinson's, attention deficit hyperactivity disorder (ADHD) [37][38][39][40], as well as psychiatric disorders [41]. Zinc deficiency is associated with AD, while Zn supplementation has been linked to a reduced prevalence of AD and slowed disease progression [37].…”

Section: Discussionsupporting

confidence: 89%

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Effects of Zinc Supplementation on Inflammatory and Cognitive Parameters in Middle-Aged Women with Overweight or Obesity

de Vargas,

Jantsch,

Fontoura

et al. 2023

Nutrients

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Obesity has been linked to cognitive decline and adverse effects on brain health. Zinc (Zn) is a mineral with important metabolic functions that can modulate obesity-related neurological impairment. Thus, the present study aimed to evaluate the effects of 12 weeks of Zn supplementation on the inflammatory profile, cognitive function, and mood of overweight or obese women through a double-blind, placebo-controlled study. The study included 42 women aged between 40 and 60, randomly divided into two groups: Zn supplementation (30 mg/day) or placebo for 12 weeks. Data regarding sociodemographic, anthropometric, dietary, and physical activity were collected. Mini-mental state examination (MMSE), verbal fluency test, clock drawing test, and Stroop test were performed. Anxiety and depression symptoms were assessed using the Beck anxiety inventory and the BDI-II, respectively. Saliva samples were collected to evaluate IL-1β, IL-6, TNF-α, insulin, nitrite, and Zn levels. Of the 42 participants (mean age 49.58 ± 6.46 years), 32 were included in the study analyses. Changes in body weight and macronutrient consumption were not different between placebo and Zn supplementation groups. Cognitive scores on the MMSE and Stroop tests were higher in the Zn supplementation group than in the placebo group. Salivary levels of IL-1b and Zn increased in the Zn group compared to placebo. There was no significant change in the adjusted means of the BDI-II and BECK scores between the zinc vs. placebo groups. Twelve weeks of Zn supplementation was able to partially improve the cognitive scores assessed in overweight or obese women, regardless of weight loss. These findings suggest that Zn supplementation can be considered an adjunct strategy to enhance cognitive health in overweight or obese women.

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Section: Discussionsupporting

confidence: 89%

“…Zinc is regulated by complex mechanisms of absorption, transport, and excretion, which aim to keep zinc levels in balance. Deregulations in this homeostasis can lead to deficiencies or excesses of zinc concentrations, both harmful to the central nervous system (CNS) and health [4,5].…”

Section: Introductionmentioning

confidence: 99%

Effects of Zinc Supplementation on Inflammatory and Cognitive Parameters in Middle-Aged Women with Overweight or Obesity

de Vargas,

Jantsch,

Fontoura

et al. 2023

Nutrients

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“…A consensus is coalescing around the idea that altered homeostatic levels of Zn 2+ play a significant role in many neurological disorders. These disorders (reviewed by Wang et al 84 ) include neurodegenerative conditions such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS); psychiatric disorders such as depression and schizophrenia; epilepsy; and traumatic brain injury. In the case of neurodegenerative disorders, especially PD, it is important to understand how DA regulation is altered.…”

Section: ■ Discussionmentioning

confidence: 99%

Caged Zn²⁺ Photolysis in Zebrafish Whole Brains Reveals Subsecond Modulation of Dopamine Uptake

Hettiarachchi,

Niyangoda,

Shigemoto

et al. 2024

ACS Chem. Neurosci.

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Free, ionic zinc (Zn 2+ ) modulates neurotransmitter dynamics in the brain. However, the sub-s effects of transient concentration changes of Zn 2+ on neurotransmitter release and uptake are not well understood. To address this lack of knowledge, we have combined the photolysis of the novel caged Zn 2+ compound [Zn(DPAdeCageOMe)] + with fast scan cyclic voltammetry (FSCV) at carbon fiber microelectrodes in live, whole brain preparations from zebrafish (Danio rerio). After treating the brain with [Zn(DPAdeCageOMe)] + , Zn 2+ was released by application of light that was gated through a computer-controlled shutter synchronized with the FSCV measurements and delivered through a 1 mm fiber optic cable. We systematically optimized the photocage concentration and light application parameters, including the total duration and light-to-electrical stimulation delay time. While sub-s Zn 2+ application with this method inhibited DA reuptake, assessed by the first-order rate constant (k) and half-life (t 1/2 ), it had no effect on the electrically stimulated DA overflow ([DA] STIM ). Increasing the photocage concentration and light duration progressively inhibited uptake, with maximal effects occurring at 100 μM and 800 ms, respectively. Furthermore, uptake was inhibited 200 ms after Zn 2+ photorelease, but no measurable effect occurred after 800 ms. We expect that application of this method to the zebrafish whole brain and other preparations will help expand the current knowledge of how Zn 2+ affects neurotransmitter release/uptake in select neurological disease states.

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“…Disruptions to Zn 2+ homeostasis might be associated with several disorders affecting the central nervous system, like Alzheimer's disease, Parkinson's disease, and depression [35]. Some Zn 2+ -containing transcription factors such as NF-κB and the tumour protein P53 (p53) participate in amyloid precursor protein (APP) synthesis.…”

Section: Zinc (Zn)mentioning

confidence: 99%

Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

Tyczyńska,

Gędek,

Brachet

et al. 2024

JCM

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Changes in trace element concentrations are being wildly considered when it comes to neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. This study aims to present the role that trace elements play in the central nervous system. Moreover, we reviewed the mechanisms involved in their neurotoxicity. Low zinc concentrations, as well as high levels of copper, manganese, and iron, activate the signalling pathways of the inflammatory, oxidative and nitrosative stress response. Neurodegeneration occurs due to the association between metals and proteins, which is then followed by aggregate formation, mitochondrial disorder, and, ultimately, cell death. In Alzheimer’s disease, low Zn levels suppress the neurotoxicity induced by β-amyloid through the selective precipitation of aggregation intermediates. High concentrations of copper, iron and manganese cause the aggregation of intracellular α-synuclein, which results in synaptic dysfunction and axonal transport disruption. Parkinson’s disease is caused by the accumulation of Fe in the midbrain dopaminergic nucleus, and the pathogenesis of multiple sclerosis derives from Zn deficiency, leading to an imbalance between T cell functions. Aluminium disturbs the homeostasis of other metals through a rise in the production of oxygen reactive forms, which then leads to cellular death. Selenium, in association with iron, plays a distinct role in the process of ferroptosis. Outlining the influence that metals have on oxidoreduction processes is crucial to recognising the pathophysiology of neurodegenerative diseases and may provide possible new methods for both their avoidance and therapy.

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Zinc and Central Nervous System Disorders

Cited by 22 publications

References 262 publications

Effects of Zinc Supplementation on Inflammatory and Cognitive Parameters in Middle-Aged Women with Overweight or Obesity

Effects of Zinc Supplementation on Inflammatory and Cognitive Parameters in Middle-Aged Women with Overweight or Obesity

Caged Zn²⁺ Photolysis in Zebrafish Whole Brains Reveals Subsecond Modulation of Dopamine Uptake

Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

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Zinc and Central Nervous System Disorders

Cited by 22 publications

References 262 publications

Effects of Zinc Supplementation on Inflammatory and Cognitive Parameters in Middle-Aged Women with Overweight or Obesity

Effects of Zinc Supplementation on Inflammatory and Cognitive Parameters in Middle-Aged Women with Overweight or Obesity

Caged Zn2+ Photolysis in Zebrafish Whole Brains Reveals Subsecond Modulation of Dopamine Uptake

Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

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Caged Zn²⁺ Photolysis in Zebrafish Whole Brains Reveals Subsecond Modulation of Dopamine Uptake