Zinc and Copper in Indian Patients of Tuberculosis: Impact on Antitubercular Therapy

Abstract

The effectiveness and success of antitubercular therapy is mainly measured by identifying the organism in sputum. In certain patients, especially in geriatric patients, available tuberculosis tests are not satisfactory and do not provide enough information on the effectiveness of antitubercular therapy, as the symptoms might be confused with the existing symptoms of ongoing diseases. Therefore, 60 diagnosed and randomly selected patients with tuberculosis were included into this study. The patients with other associated diseases likely to influence serum copper and zinc were not included in the study. The estimations of serum copper and zinc were done in healthy volunteers and in tubercular patients before the start of treatment and after 4 wk of antitubercular treatment. The average plasma concentration of serum copper and zinc in healthy volunteers were 102 +/- 20 microg/dL and 96 +/- 18 microg/dL respectively. In tuberculosis patients, serum copper and zinc levels were 123.65 +/- 9.98 microg/dL and 64.14 +/- 3.97 microg/dL, respectively, before the start of treatment, which came down to 116.23 +/- 4.27 mug/dL and 74.31 +/- 3.60 microg/dL, respectively, after 4 wk of antitubercular treatment.

Comparative study of serum copper, zinc, Cu/Zn ratio in pulmonary tuberculosis patients with normal subjects

“…Every year, 8 million people contact tuberculosis of which 95% are in the developing world. 1 It is estimated that between 2002 and 2020, tuberculosis will be affect nearly 1 million people and 35 million will be die of tuberculosis, if it is not controlled. Therefore control of Tuberculosis and better chemotherapy is still a challenge in the management of tuberculosis infection in the 21 st century.…”

Macro- And Microelements of Blood Plasma in Pulmonary Tuberculosis

“…It is known that the level of micro-and macroelements in blood plasma significantly changes in different diseases [3]. However, the existing literature data about disorders in the element homeostasis of blood plasma in pulmo nary tuberculosis are rather contradictory [4][5][6].…”

“…Однако имеющиеся литератур ные данные о нарушении элементного гомеостаза плазмы крови при туберкулезе легких достаточно противоречивы [4][5][6].…”

Level of Macronutrients and Microelements of Blood Plasma in Different Forms of Pulmonary Tuberculosis

“…It is known that the level of micro-and macronutrients in blood plasma varies significantly with various diseases [2]. However, the available literature data on the violation of elemental homeostasis of blood plasma in pulmonary tuberculosis are quite contradictory [3] [4]. In addition, since the average values of the content of micro-and macronutrients in practically healthy people living in different regions may differ, it is necessary to rely on the values of the norm for a particular area of residence.…”