2018
DOI: 10.1016/j.nut.2017.07.009
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Zinc and selenium status in critically ill patients according to severity stratification

Abstract: Plasma concentrations of zinc and selenium are low in critically ill patients upon admission to the intensive care unit and may make these patients more susceptible to oxidative stress. The low concentration of erythrocyte selenium may represent an inadequate intake by this population. Additional studies using new biomarkers should be performed with the objective of identifying values for the local population.

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Cited by 26 publications
(20 citation statements)
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“…Nangliya et al also reported that serum zinc concentrations were correlated with the severity of liver cirrhosis [44]. In addition, Elmasry et al reported that the serum zinc concentrations were inversely correlated with the organ failure index and organ dysfunction score in critically ill children in the pediatric intensive-care unit [45,46]. Although the mechanism of disease-related zinc concentration was unclear in these previous reports, our results suggest that amount of infiltrating monocytes with these inflammatory conditions was related with disease severity and inversely associated with the zinc serum concentration.…”
Section: Discussionmentioning
confidence: 99%
“…Nangliya et al also reported that serum zinc concentrations were correlated with the severity of liver cirrhosis [44]. In addition, Elmasry et al reported that the serum zinc concentrations were inversely correlated with the organ failure index and organ dysfunction score in critically ill children in the pediatric intensive-care unit [45,46]. Although the mechanism of disease-related zinc concentration was unclear in these previous reports, our results suggest that amount of infiltrating monocytes with these inflammatory conditions was related with disease severity and inversely associated with the zinc serum concentration.…”
Section: Discussionmentioning
confidence: 99%
“…The weight of evidence suggests that zinc (Zn) is a highly effective NF-κB inhibitor in vivo [ [307] , [308] , [309] ]. This is of particular interest as several authors have reported grossly depleted Zn levels in patients with severe infections, sepsis and ARDS hence there is a case for Zn supplementation in COVID-19 [ [310] , [311] , [312] , [313] ]. It is also noteworthy that vitamin C levels are also commonly depleted in patients with sepsis and ARDS [ 314 , 315 ] and several authors have reported downregulation of NF-κB following its administration [ 316 , 317 ].…”
Section: Suggestions For Therapeutic Interventionmentioning
confidence: 99%
“…There were eight independent studies that examined plasma zinc concentrations in chronic diseases (18)(19)(20)(21)(22)(23)(24)(25) . Zinc concentrations were significantly lower with increasing CRP concentrations from minor to moderate to major inflammation by approximately 25 %.…”
Section: Systematic Reviewmentioning
confidence: 99%