Zinc and the steroid endocrinology of the human prostate

Habib, Fouad K.

doi:10.1016/0022-4731(78)90608-8

Cited by 56 publications

(23 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We have recently demonstrated that Zn ions inhibit androgen metabolism in the prostate (Habib, 1978). The results reported in this paper also indicate that the hormonal changes in the tissue were manifested only after the Zn concentrations had reached physiologically subnormal levels.…”

Section: D)iscussionsupporting

confidence: 63%

“…Indeed, a number of investigators have reported a degree of overlap between the various groups (Schrodt et al, 1964;Geller et al, 1978). Recent in vitro studies have revealed, however, that the concentration of Zn in prostatic cells influences androgen metabolism, on which prostatic growth and function depend (Grant et al, 1l975;Habib, 1978 (BPH). No patient had received any treatiient for at least 1 monith before the study.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Cancer of the prostate: Early diagnosis by zinc and hormone analysis?

Habib¹,

Mason²,

Smith³

et al. 1979

Br J Cancer

View full text Add to dashboard Cite

Summary.-Zinc, testosterone and dihydrotestosterone concentrations have been measured in normal prostatic tissue and in specimens obtained from untreated patients with benign prostatic hyperplasia (BPH) and carcinoma of the prostate (CaP). The metal-androgen relationship was examined and related to the pathological condition of the patients.The evidence suggests that discriminant analysis combining the hormonal data into a single variable is a reliable test for distinguishing between BPH and CaP patients. We have observed that the high Zn values found in BPH specimens were always associated with a DTH : T ratio >1. Androgen tissue ratios <1 were characteristic of all CaP specimens, and these were usually preceded by a reduction in prostatic Zn concentration. Since these patterns, particularly those associated with neo-

show abstract

Section: D)iscussionsupporting

confidence: 63%

mentioning

confidence: 99%

Cancer of the prostate: Early diagnosis by zinc and hormone analysis?

Habib¹,

Mason²,

Smith³

et al. 1979

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…Investigations of testicular androgen levels in human specimens have also been reported [12, 18,28, 291 but simultaneous measurements of male hormones in human testis and epididymis are rather scant [13, 231. Zinc (Zn) has been found in high concentrations in male accessory sex organs [15] and it was suggested that this metal influences the acti=.ities of the Sty-reductase and 3a-hydroxy-steroid-dehydrogenase enzymes [8,9,171. This study is concerned with the simultaneous determination of testosterone, dihydrotestosterone (DHT), and Zn in human testis and epididymis.…”

Section: Introductionmentioning

confidence: 99%

Testosterone, Dihydrotestosterone, and Zinc Concentrations in Human Testis and Epididymis

Suescun

Campo

Rivarola

et al. 1981

Archives of Andrology

View full text Add to dashboard Cite

Tissue testosterone, dihydrotestosterone, and zinc concentrations have been determined in testis and epididymis of 13 patients with carcinoma of the prostate, 1 patient with carcinoma of the penis, and 3 patients with carcinoma of the prostate on estrogens. The 13 patients not receiving estrogens had the following testicular levels: testosterone, of 529 t 63.1 ng/g (mean -+ SE); dihydrotestosterone, 23.7 t 2.58 ng/g; and zinc 62.2 -+ 7.6 &g. The epididymal levels were as follows: testosterone, 40.6 2 3.4 ngig; dihydrotestosterone, 20.5 2 2.36 ng/g; and zinc, 67.2 2 1 1 . 1 pg/g. Patients on estrogen therapy showed much lower androgen values in the two organs but zinc was not changed significantly. Concentrations of androgens were not significantly different in the epididymal fractions of caput, corpus, and cauda. In testis, there was a positive correlation between zinc and androgens contents, while the opposite was suggested by the data in the epididymis. Even though these patients were not normal, there was no evidence of testicular or epididymal disturbances.

show abstract

“…The plasma concentration of follicle-stimulating hormone (FSH) has been reported as normal or reduced [6,7,24,25]. It has also been reported that the plasma con centration of testosterone (T) is normal but, on challenging the pituitary with luteinizingreleasing hormone, secretion of T into the plasma is lower than that in control animals, indicating a smaller reserve in the testes of protein-deficient rats [6,7], Similarly diverse results have been re ported for the response of plasma levels of LH, FSH and T to dietary zinc deficiency [11,19] but, despite reports of an association of zinc deficiency with impairment of the re productive function in humans [8,19] and ex perimental animals [1,13,14,23], the precise role of zinc in the function of the reproduc tive endocrine system has not been defined.…”

Section: Introductionmentioning

confidence: 99%

Response of the Reproductive System of Male Rats to Protein and Zinc Deficiency during Puberty

Salem¹,

Coward²,

Lunn³

et al. 1984

Ann Nutr Metab

View full text Add to dashboard Cite

Male weanling rats were fed four diets providing high or low levels of protein and/or zinc. One group on each diet was sacrificed every 2 weeks to measure the weights of the reproductive organs, plasma levels of follicle-stimulating hormone and luteinizing hormone, and the plasma and testicular concentrations of testosterone, dihydrotestosterone and zinc. The results demonstrate that hypogonadal states are produced in response to protein deficiency and zinc deficiency but the mechanisms involved are different. The specific effects of zinc deficiency are not observed in protein-deficient animals.

show abstract

Zinc and the steroid endocrinology of the human prostate

Cited by 56 publications

References 31 publications

Cancer of the prostate: Early diagnosis by zinc and hormone analysis?

Cancer of the prostate: Early diagnosis by zinc and hormone analysis?

Testosterone, Dihydrotestosterone, and Zinc Concentrations in Human Testis and Epididymis

Response of the Reproductive System of Male Rats to Protein and Zinc Deficiency during Puberty

Contact Info

Product

Resources

About