Zinc-containing tricalcium phosphate and related materials for promoting bone formation

Ito, Atsuo; Otsuka, Makoto; Kawamura, Haruo; Ikeuchi, Masako; Ohgushi, Hajime; Sogo, Yu; Ichinose, Noboru

doi:10.1016/j.cap.2004.10.006

Cited by 135 publications

(81 citation statements)

References 22 publications

(20 reference statements)

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“…Zinc as the bone mineral in one of the most abundant trace elements can promote bone formation on osteoblasts and inhibit bone resorption on osteoclasts in vivo and in vitro 5) . It can also promote bone metabolism, growth, mineralization, increase bone density and prevent bone resorption 6) .…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility and Anti-Bacterial Activity of Zn-Containing HA/TiO2 Hybrid Coatings on Ti Substrate

Zhang

2013

J. Hard Tissue Biology.

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Abstract. To improve the osteogenic and anti-bacterial activity for the hydroxyapatite coated titanium substrate Zn containing HA biological coating was prepared on commercially pure Ti via the sol-gel method after treatment by oxidation which produced a porous titania coating on the titanium. The phase structures of the coatings were characterized by X-ray diffraction. The release concentration of zinc was measured by an inductively coupled plasma spectrometer. In vitro co-culture assays were performed to evaluate the cell morphology and attachment of MG-63 cells to the coated titanium. The anti-bacterial effect of the ZnHA/TiO 2 coating was evaluated on Porphyromonas gingivalis w83. The cell micro morphology on the ZnHA/TiO 2 coatings was more polygonal than that of HA/TiO 2 coatings when viewed by SEM. It was confirmed by fluorescence microscopy observations that the MG-63 cells on the hybrid coating layer were favorably adhered. Compared with the HA/TiO 2 coating, the ZnHA/TiO 2 coating significantly inhibited the growth of Porphyromonas gingivalis. The results suggest that the ZnHA/TiO 2 hybrid coatings on titanium implants should possess better mechanical binding properties and biocompatibility.

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Section: Introductionmentioning

confidence: 99%

Biocompatibility and Anti-Bacterial Activity of Zn-Containing HA/TiO2 Hybrid Coatings on Ti Substrate

Zhang

2013

J. Hard Tissue Biology.

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“…Other aspect of particular importance is that has been increasing interest in the use of pharmacological agents to promote tissue regeneration around implanted biomaterials. Of the many trace elements, zinc is reported to be involved in bone metabolism [7][8][9][10] , showing that Zn 2+ increases bone protein, calcium content, and alkaline phosphatase activity in rat calvaria 11 . Other role of zinc is protecting biological structures from damage by free radicals 12 .…”

Section: Introductionmentioning

confidence: 99%

Characterization of calcium phosphate coating and zinc incorporation on the porous alumina scaffolds

et al. 2007

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Bone ingrowth requires materials with the existence of open and interconnected pores with diameters larger than 150 µm for proper circulation of nutrients. Such materials must possess enough mechanical strength to avoid failure whilst offering a bioactive surface for bone regeneration. We have developed porous ceramic alumina scaffold with compressive strength that achieves 3.3 MPa by replication method by using the network structure of cellular polymer foam. However, the biocompatibility of ceramics based on Al 2 O 3 requires further improvement so that it could have strong bonding to natural bone tissue. To address this problem of the interface between alumina and bone, we have developed a novel calcium phosphate with Zn 2+ (CaP-Zn) coating onto porous alumina ceramic scaffold by impregnating with calcium phosphate/poly(vinyl alcohol) slurry. The tri-dimensional alumina scaffold coated with CaP-Zn was extensively characterized by SEM, EDS and FTIR.

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“…TCP for rapid release or HA for tardy release) and the content of substituted ions [146,178]. However, whether a clear relation between the two parameters and the releasing profile can be drawn is questionable since the substitution of foreign ions in calcium phosphates commonly leads to a change of their chemical stability and dissolution rate [52,135,153,179].…”

Section: Control the Release Of Ionsmentioning

confidence: 99%

“…silicon [121,122], zinc [123][124][125][126], strontium [122,127,128]) into synthetic bioceramics and improved biological performance was observed both in vitro and in vivo (e.g. silicon [49,121,129], zinc [39,[123][124][125][130][131][132][133][134][135][136][137][138][139][140], strontium [141,122,127,128,131,140,[142][143][144][145][146][147][148][149][150][151][152][153] and fluoride [64,65,67,69,<...>…”

Section: Improve the Biological Performance Of Calcium Phosphates Witmentioning

confidence: 99%

“…Thereafter, zinc has been introduced in various calcium phosphates ceramics in expectation that the release of zinc may promote the bone forming ability of synthetic materials. Naturally it was found that zinc-containing materials would release zinc, and influence the differentiation of osteogenic cells [208] and hence promote the regeneration of nearby host bone [132,135], suggesting their potential role in improving conductive bone formation at osseous site.…”

Section: Introductionmentioning

confidence: 99%

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Improving the bone forming ability of synthetic bone substitutes using trace element additions

Luo¹

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Zinc-containing tricalcium phosphate and related materials for promoting bone formation

Cited by 135 publications

References 22 publications

Biocompatibility and Anti-Bacterial Activity of Zn-Containing HA/TiO2 Hybrid Coatings on Ti Substrate

Biocompatibility and Anti-Bacterial Activity of Zn-Containing HA/TiO2 Hybrid Coatings on Ti Substrate

Characterization of calcium phosphate coating and zinc incorporation on the porous alumina scaffolds

Improving the bone forming ability of synthetic bone substitutes using trace element additions

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