Zinc, copper, and oxysterol levels in patients with type 1 and type 2 diabetes mellitus

Samadi, Afshin; İşikhan, Selen Yilmaz; Tinkov, Alexey A.; Lay, İncilay; Doşa, Monica Daniela; Skalny, Anatoly V.; Skalnaya, Margarita G.; Chirumbolo, Salvatore; Bjørklund, Geir

doi:10.1016/j.clnu.2019.07.026

Cited by 36 publications

(37 citation statements)

References 61 publications

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“…It is known that Zn is necessary for the synthesis of insulin and that higher Zn intake is associated with lower risk of developing type 2 diabetes (14). Moreover, Zn levels were reduced in patients with type 1 and type 2 diabetes (15). Based on HOMA‐IR, we did not find a protective effect of Zn on insulin sensitivity, as HOMA‐IR was increased in both CAF and CAF+Zn groups.…”

Section: Discussionmentioning

confidence: 99%

Zinc Supplementation Decreases Obesity‐Related Neuroinflammation and Improves Metabolic Function and Memory in Rats

Oliveira

Feijó

Neto

et al. 2020

Obesity

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Objective: The purpose of this study was to evaluate the effects of zinc (Zn) supplementation on metabolic and neuroinflammatory parameters in cafeteria diet (CAF)-induced obesity in Wistar rats. Methods: Animals were divided into four groups: control diet (CT); CT+Zn; CAF; CAF+Zn. The diet was administered for 20 weeks; Zn treatment (10 mg/kg/d) started at week 16 and it was conducted until the end of the diet protocol. Weight gain, visceral fat, and plasma levels of glucose, triglycerides, insulin, TNF-α, and IL-6, as well as homeostatic model assessment of insulin resistance, were assessed. Glial fibrillary acidic protein (GFAP) and ionized calcium binding adaptor molecule 1 (Iba-1) expression in the cerebral cortex and toll-like receptor 4 (TLR-4) in the cerebral cortex and hippocampus were evaluated. Memory was assessed by the novel object recognition test. Results: CAF diet increased weight gain, visceral fat, and plasma glucose, triglyceride, and TNF-α levels. Zn reversed the hyperglycemia caused by CAF diet and reduced IL-6 levels. In the cerebral cortex, GFAP was similar between groups; Iba-1 was increased by CAF diet but reduced in the CAF+Zn group. Zn reduced CAF-dependent TLR-4 increase in the hippocampus but not in the cerebral cortex. CAF-fed animals showed impaired recognition memory, whereas Zn reversed it. Conclusions: These findings demonstrate that Zn partially reverted obesity-related metabolic dysfunction and reduced neuroinflammation and memory deficit caused by CAF diet.

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Section: Discussionmentioning

confidence: 99%

Zinc Supplementation Decreases Obesity‐Related Neuroinflammation and Improves Metabolic Function and Memory in Rats

Oliveira

Feijó

Neto

et al. 2020

Obesity

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“…Consequently, these micronutrients are hypothesized to be involved in DM and MetS [3][4][5]. A few observational studies were designed to clarify the associations between serum concentrations of Zn, Cu, or Fe and DM, but the results were inconsistent [6][7][8]. In recent meta-analyses, it seems that serum levels of Cu and Fe tend to be positively associated with the risk of DM, while the association between serum levels of Zn and DM was inconclusive [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

Lee

Kuo

et al. 2021

Nutrients

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The association between serum concentrations of zinc, copper, or iron and the risk of metabolic syndrome are inconclusive. Therefore, we conduct a case-control study to explore the relationship between serum levels of zinc, copper, or iron and metabolic syndrome as well as each metabolic factor and insulin resistance. We enrolled 1165 adults, aged ≥ 40 (65.8 ± 10) years in a hospital-based population to compare the serum levels of zinc, copper, and iron between subjects with and without metabolic syndrome by using multivariate logistic regression analyses. The least square means were computed by general linear models to compare serum concentrations of zinc, copper, and iron in relation to the number of metabolic factors. The mean serum concentrations of zinc, copper, and iron were 941.91 ± 333.63 μg/L, 1043.45 ± 306.36 μg/L, and 1246.83 ± 538.13 μg/L, respectively. The odds ratios (ORs) of metabolic syndrome for the highest versus the lowest quartile were 5.83 (95% CI: 3.35–10.12; p for trend < 0.001) for zinc, 2.02 (95% CI: 1.25–3.25; p for trend: 0.013) for copper, and 2.11 (95% CI: 1.24–3.62; p for trend: 0.021) for iron after adjusting for age, sex, personal habits, body mass index, and homeostatic model assessment insulin resistance. Additionally, the serum zinc, copper, and iron concentrations increased as the number of metabolic factors rose (p for trend < 0.001). This was the first study to clearly demonstrate that higher serum levels of zinc, copper, and iron were associated with the risk of metabolic syndrome and the number of metabolic factors independent of BMI and insulin resistance.

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“…Whole blood zinc levels in diabetic patients were significantly lower than in those of control subjects 54) . Furthermore, some reports also have shown that plasma zinc/copper ratio was decreased in patients with both type 1 and type 2 diabetes than in healthy subjects 55,56) .…”

Section: -5 Blood Zinc Levels In Abnormal Glucose Metabolismmentioning

confidence: 95%

The Role of Zinc Homeostasis in the Prevention of Diabetes Mellitus and Cardiovascular Diseases

Tamura

2021

JAT

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Zinc is an essential micronutrient for human health and is involved in various biological functions, such as growth, metabolism, and immune function. In recent years, research on intracellular zinc dynamics has progressed, and it has become clear that zinc transporters strictly control intracellular zinc localization, zinc regulates the functions of various proteins and signal transduction pathways as a second messenger similar to calcium ions, and intracellular zinc dyshomeostasis is associated with impaired insulin synthesis, secretion, sensitivity, lipid metabolism, and vascular function. Numerous animal and human studies have shown that zinc deficiency may be associated with the risk factors for diabetes and cardiovascular diseases (CVDs) and zinc administration might be beneficial for the prevention and treatment of these diseases. Therefore, an understanding of zinc biology may help the establishment of novel strategies for the prevention and treatment of diabetes and CVDs. This review will summarize the current knowledge on the role of zinc homeostasis in the pathogenesis of diabetes and atherosclerosis and will discuss the potential of zinc in the prevention of these diseases.in the skin and liver, and the remaining 2%-3% is in all the other tissues, including blood and blood vessels. Zinc deficiency is well known to be involved in various disorders in the whole-body, such as growth failure, immune disorders, and dysgeusia 5) . Furthermore, zinc deficiency also increases the risk for diabetes and CVDs 6, 7) . Recent findings have shown that intracellular zinc homeostasis regulated by zinc transporters is involved in the regulation of insulin synthesis, secretion, sensitivity, and vascular function 6,8) . This review will discuss the role of impaired intracellular zinc homeostasis in the pathogenesis of diabetes and atherosclerosis and whether zinc supplementation is beneficial for the prevention of these diseases. Intracellular Zinc HomeostasisZinc is a divalent cation and can bind to ~10% of all proteins found in the human body and functionsCopyright©2021 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

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Zinc, copper, and oxysterol levels in patients with type 1 and type 2 diabetes mellitus

Cited by 36 publications

References 61 publications

Zinc Supplementation Decreases Obesity‐Related Neuroinflammation and Improves Metabolic Function and Memory in Rats

Zinc Supplementation Decreases Obesity‐Related Neuroinflammation and Improves Metabolic Function and Memory in Rats

Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

The Role of Zinc Homeostasis in the Prevention of Diabetes Mellitus and Cardiovascular Diseases

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