Zinc, copper, sirtuin 1 concentration, and glucose metabolism parameters in the blood of women with polycystic ovary syndrome

Bizoń, Anna; Słowiak, Anna; Franik, Grzegorz; Biernacka-Bartnik, Aleksandra; Madej, Paweł

doi:10.1080/09513590.2020.1751111

Cited by 7 publications

(4 citation statements)

References 35 publications

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“…Zinc is considered as one of the cofactors of antioxidant enzymes, such as catalase (CAT) and SOD1 [72]. While the studies described in this review did not show any changes in SOD1 activity, changes in serum zinc concentration, serum copper concentration, as well as Cu/Zn ratio were observed in woman with PCOS [29,47,51]. Higher generation of ROS is postulated as one of the factors involved in the etiopathogenesis of PCOS [73], because it results in lipid peroxidation and damage of cell membrane lipids [48].…”

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 75%

“…In these women also glucose metabolism parameters (except SIRT1-sirtuin 1) were significantly higher. Above disturbances could result from overweight/obesity and insulin resistance [29].…”

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

“… Involvement of zinc in female reproductive system according to [ 19 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. Abbreviations: CAT: catalase; Cu/Zn SOD: Cu/Zn superoxide dismutase; FSH: follicle stimulating hormone; GPx: glutathione peroxidase; GSH: glutathione; HDL: high density lipoprotein; LDL: low density lipoprotein; LH: luteinizing hormone; MMPs: matrix metalloproteinases; MTs: metallothioneines; NF-κB: nuclear factor κB; PGs: prostaglandins; TG: triglycerides; TXA 2 : thromboxane A 2 .…”

Section: Figurementioning

confidence: 99%

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The Role of Zinc in Selected Female Reproductive System Disorders

et al. 2020

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Zinc is an essential microelement that plays many important functions in the body. It is crucial for the regulation of cell growth, hormone release, immunological response and reproduction. This review focuses on its importance in the reproductive system of women of reproductive and postmenopausal ages, not including its well described role in pregnancy. Only recently, attention has been drawn to the potential role of zinc in polycystic ovary syndrome (PCOS), dysmenorrhea, or endometriosis. This review is mainly based on 36 randomized, controlled studies on reproductive, pre- and post-menopausal populations of women and on research trying to explain the potential impact of zinc and its supplementation in the etiology of selected female reproductive system disorders. In women with PCOS, zinc supplementation has a positive effect on many parameters, especially those related to insulin resistance and lipid balance. In primary dysmenorrhea, zinc supplementation before and during each menstrual cycle seems to be an important factor reducing the intensity of menstrual pain. On the other hand, little is known of the role of zinc in endometriosis and in postmenopausal women. Therefore, further studies explaining the potential impact of zinc and its supplementation on female reproductive system would be highly advisable and valuable.

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Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 75%

“…In these women also glucose metabolism parameters (except SIRT1-sirtuin 1) were significantly higher. Above disturbances could result from overweight/obesity and insulin resistance [29].…”

Section: Zinc and Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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The Role of Zinc in Selected Female Reproductive System Disorders

et al. 2020

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“…For example, the urinary As concentration is positively correlated with FSH and LH levels and negatively correlated with AMH and estradiol levels (Pan et al 2020). Analogously, the blood Cu concentration is likely to increase in PCOS patients (Kurdoglu et (Bizon et al 2020). Excess Cu might induce oxidative stress, causing an increase in reactive oxygen species (ROS) (Pereira et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Assessment Between Follicular Fluid Multiple Element Concentrations and Hormonal Profiles of Women with Polycystic Ovary Syndrome

et al. 2023

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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women. Follicular uid quality affects early embryonic development and multiple stages of pregnancy. This study measured 12 elements in follicular uid and 5 blood hormones, aiming to identify the associations between multielement concentrations, as well as blood hormone levels, and PCOS to investigate the interference of multielement coexposure on PCOS and examine the potential roles of hormones. Eight elements (As, Cu, Se, Sr, V, Zn, Cr, Ca), but not Mg, showed a positive dose-effect relationship with PCOS. The OPLS models of follicle-stimulating hormone (FSH) and anti-Müllerian hormone (AMH) with relevant elements showed that Mg, Zn, Fe, Se and V had a more signi cant effect on FSH and that As, Se, V, Cu and Zn were positively correlated with AMH (VIP > 1). Further analysis indicated a synergistic effect for FSH and Mg, both of which were protective factors against PCOS; the associations between the ve elements and PCOS incidence were mediated by AMH. Changes in hormone levels between multielement coexposure and PCOS development suggest that FSH and Mg are protective against PCOS; female exposure to As, Se, V, Cu, and Zn may affect PCOS progression by perturbing AMH levels. c p values of all parameters were obtained by non-parametric Mann-Whitney U test. * indicates p < 0.05, ** indicates p < 0.01.d IVF: In Vitro Fertilization e ICSI: Intracytoplasmic sperm injection

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