Zinc deficiency is not a cause for abortion, congenital abnormality and small‐for‐gestational age infant in Chinese women

Ghosh, Anupam; Fong, Louise Y.Y.; Wan, C. W.; Liang, S. T.; Woo, J. S. K.; Wong, Vivian Taam

doi:10.1111/j.1471-0528.1985.tb03067.x

Cited by 48 publications

(14 citation statements)

References 17 publications

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“…A study in the USA also found that, among both white and black mothers, serum zinc concentration was significantly related to birthweight after various independent determinants of birthweight were controlled (36). A similar association was also documented by studies in Turkey (37), India (38), and China (39). …”

Section: Discussionsupporting

confidence: 85%

A Systematic Review of Effect of Prenatal Zinc Supplementation on Birthweight: Meta-analysis of 17 Randomized Controlled Trials

Gebreselassie

Gashe

2011

J Health Popul Nutr

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The effect of prenatal zinc supplementation on birthweight is controversial as randomized controlled trials (RCTs) report conflicting conclusions. A systematic review which includes meta-analysis was done on 17 RCTs conducted worldwide since 1984 to assess the effect of prenatal zinc supplementation on birthweight. The studies were identified through web-based search. Heterogeneity among studies was assessed using Cochrane Q test statistic. Effect-size was measured based on standardized mean difference. Pooled effect-size was computed using a variant of random effect model. Thirteen of the 17 RCTs found no association, three reported positive association, and one reported negative association. Based on fixed and random effect models, the pooled effect-sizes were 0.0268 [95% confidence interval (CI) 0.0764, -0.0229) and 0.0712 (95% CI 0.1619, -0.0194) respectively. The effect-size estimate remains insignificant after stratification was made based on the dose of supplementation (optimal vs high dose), type of study (community vs institution-based), and type of source country (developed vs developing). The meta-analysis did not witness any association between birthweight and prenatal zinc supplementation.

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Section: Discussionsupporting

confidence: 85%

A Systematic Review of Effect of Prenatal Zinc Supplementation on Birthweight: Meta-analysis of 17 Randomized Controlled Trials

Gebreselassie

Gashe

2011

J Health Popul Nutr

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“…Twelve studies were identified that measured maternal circulating zinc in countries where inadequate zinc intake is predicted to be <17%, and looked at the association with birthweight (Table 1) [38,46,47,48,49,50,51,52,53,54,55,56]. Only one study, based on 3817 women in China, reported a 3.4-fold increase in the risk of delivering a LBW infant with serum zinc <560 µg/L (adjusted RR: 3.41, 95% CI: 1.97, 5.91) [56].…”

Section: Resultsmentioning

confidence: 99%

“…A further two studies reported circulating zinc to be lower in women who developed severe PE (blood pressure BP ≥ 160/110) compared to women whose pregnancies remained uncomplicated [73,74]. The remaining eight studies, whose sample sizes ranged from 10–271 women with PE/GH and 10–2038 women with an uncomplicated pregnancy, reported no difference in maternal zinc status between women with a hypertensive disorder of pregnancy and those without [38,47,54,75,76,77,78,79]. …”

Section: Resultsmentioning

confidence: 99%

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Association between Maternal Zinc Status, Dietary Zinc Intake and Pregnancy Complications: A Systematic Review

et al. 2016

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Adequate zinc stores in the body are extremely important during periods of accelerated growth. However, zinc deficiency is common in developing countries and low maternal circulating zinc concentrations have previously been associated with pregnancy complications. We reviewed current literature assessing circulating zinc and dietary zinc intake during pregnancy and the associations with preeclampsia (PE); spontaneous preterm birth (sPTB); low birthweight (LBW); and gestational diabetes (GDM). Searches of MEDLINE; CINAHL and Scopus databases identified 639 articles and 64 studies were reviewed. In 10 out of 16 studies a difference was reported with respect to circulating zinc between women who gave birth to a LBW infant (≤2500 g) and those who gave birth to an infant of adequate weight (>2500 g), particularly in populations where inadequate zinc intake is prevalent. In 16 of our 33 studies an association was found between hypertensive disorders of pregnancy and circulating zinc; particularly in women with severe PE (blood pressure ≥160/110 mmHg). No association between maternal zinc status and sPTB or GDM was seen; however; direct comparisons between the studies was difficult. Furthermore; only a small number of studies were based on women from populations where there is a high risk of zinc deficiency. Therefore; the link between maternal zinc status and pregnancy success in these populations cannot be established. Future studies should focus on those vulnerable to zinc deficiency and include dietary zinc intake as a measure of zinc status.

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“…In addition to its antioxidant properties zinc plays an important role in normal growth and development and biological functions such as protein synthesis and nucleic acid metabolism. 415,416 Since these are involved in cell division and growth, zinc is believed to be important for fetal growth and development. 417 The review of antioxidants (vitamins C, E and D, and zinc) included 15 RCTs (n = 4763) [418][419][420][421] with one RCT 422 added to the primary studies identified in these earlier reviews.…”

Section: Antioxidantsmentioning

confidence: 99%

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

Honest

Ca²,

Durée³

et al. 2009

Health Technol Assess

189

146

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For primary prevention, an effective, affordable and safe intervention applied to all mothers without preceding testing is likely to be the most cost-effective approach in asymptomatic women in early pregnancy. For secondary prevention among women at risk of preterm labour in later pregnancy, a management strategy based on the results of testing is likely to be more cost-effective. Implementation of a treat-all strategy with simple interventions, such as fish oils, would be premature for asymptomatic women. Universal provision of high-quality ultrasound machines in labour wards is more strongly indicated for predicting spontaneous preterm birth among symptomatic women than direct management, although staffing issues and the feasibility and acceptability to mothers and health providers of such strategies need to be explored. Further research should include investigations of low-cost and effective tests and treatments to reduce and delay spontaneous preterm birth and reduce the risk of perinatal mortality arising from preterm birth.

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Zinc deficiency is not a cause for abortion, congenital abnormality and small‐for‐gestational age infant in Chinese women

Cited by 48 publications

References 17 publications

A Systematic Review of Effect of Prenatal Zinc Supplementation on Birthweight: Meta-analysis of 17 Randomized Controlled Trials

A Systematic Review of Effect of Prenatal Zinc Supplementation on Birthweight: Meta-analysis of 17 Randomized Controlled Trials

Association between Maternal Zinc Status, Dietary Zinc Intake and Pregnancy Complications: A Systematic Review

Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling

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