Zinc Finger Protein BCL11A Contributes to the Abortive Infection of
            <i>Hirame novirhabdovirus</i>
            (HIRRV) in B Lymphocytes of Flounder (Paralichthys olivaceus)

Tang, Xiaoqian; Sun, Pingyuan; Wang, Hongxiang; Cao, Jing; Xing, Jing; Sheng, Xiuzhen; Chi, Heng; Zhan, Wenbin

doi:10.1128/jvi.01470-22

Cited by 3 publications

(1 citation statement)

References 73 publications

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“…Abscesses and septicemia caused by S. aureus can also be observed in zebrafish via the injection of bacteria in the blood (45). HIRRV infection is characterized by a pronounced viremia, and the high viral load is typically detected in immunerelated organs and the circulatory system (46). It has been shown in rats, that MPO expression in circulating neutrophils was significantly decreased after S. aureus infection (47).…”

Section: Discussionmentioning

confidence: 99%

Characterization of myeloperoxidase and its contribution to antimicrobial effect on extracellular traps in flounder (Paralichthys olivaceus)

Gan

Chi²,

Dalmo³

et al. 2023

Front. Immunol.

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Myeloperoxidase (MPO) is a cationic leukocyte haloperoxidase and together with other proteins, they possess activities against various microorganisms and are involved in extracellular trap (ET) formation. The present work describes the gene and deduced protein sequences, and functions of MPO in flounder (PoMPO). The PoMPO possesses a 2313 bp open reading frame (ORF) that encodes a protein of 770 amino acids. The highest PoMPO mRNA expression levels were found in the head kidney, followed by peritoneal cells, gill, spleen, skin, muscle, and liver. PoMPO was expressed in MHCII+ and GCSFR+ cells which indicated that PoMPO mainly is expressed in flounder macrophages and granulocytes. Bacterial lipopolysaccharide-stimulated peritoneal leukocytes showed an increased protein level of PoMPO while it seemed that LPS also promoted the migration of MPO+ cells from the head kidney into the peripheral blood and peritoneal cavity. After phorbol 12-myristate 13-acetate (PMA) or bacterial stimulation, flounder leukocytes produced typical ET structures containing DNA with decoration by MPO. The ETs containing DNA and PoMPO effectively inhibited the proliferation of ET-trapped bacteria. Blocking PoMPO with antibodies decreased the enzymatic activity, which attenuated the antibacterial activity of ETs. This study pinpoints the involvement of ETs in flounder innate responses to pathogens.

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Section: Discussionmentioning

confidence: 99%

Characterization of myeloperoxidase and its contribution to antimicrobial effect on extracellular traps in flounder (Paralichthys olivaceus)

Gan

Chi²,

Dalmo³

et al. 2023

Front. Immunol.

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Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression

Rajendiran,

Devaraju,

Haddad

et al. 2024

Molecular Therapy

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Abortive Infection of Animal Cells: What Goes Wrong

Embry,

Gammon

2024

Annual Review of Virology

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Even if a virus successfully binds to a cell, defects in any of the downstream steps of the viral life cycle can preclude the production of infectious virus particles. Such abortive infections are likely common in nature and can provide fundamental insights into the cell and host tropism of viral pathogens. Research over the past 60 years has revealed an incredible diversity of abortive infections by DNA and RNA viruses in various animal cell types. Here we discuss the general causes of abortive infections and provide specific examples from the literature to illustrate the range of abortive infections that have been reported. We also discuss how abortive infections can have critical roles in shaping host immune responses and in the development of virus-induced cancers. Finally, we describe how abortive infections can be applied to basic and clinical research, underscoring the importance of understanding these fascinating aspects of virus biology.

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Zinc Finger Protein BCL11A Contributes to the Abortive Infection of Hirame novirhabdovirus (HIRRV) in B Lymphocytes of Flounder (Paralichthys olivaceus)

Cited by 3 publications

References 73 publications

Characterization of myeloperoxidase and its contribution to antimicrobial effect on extracellular traps in flounder (Paralichthys olivaceus)

Characterization of myeloperoxidase and its contribution to antimicrobial effect on extracellular traps in flounder (Paralichthys olivaceus)

Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression

Abortive Infection of Animal Cells: What Goes Wrong

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