Zinc Glucagon Depression of Blood Amino Acids in Rabbits

Bromer, William W.; Chance, Ronald E.

doi:10.2337/diab.18.11.748

Cited by 21 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…to levels not different from zero time amino acids shown except alanine and Glucagon has recently been reported -to affect concentrations of individual plasma amino acids in man (31) and animals (32). The present findings confirm the observed effect of a decrease in levels of most amino acids and of previous studies in which total amino acids (as alpha-amino nitrogen) were measured (33).…”

Section: Discussionsupporting

confidence: 82%

Glucagon levels and metabolic effects in fasting man

Eb¹,

Aoki²,

Unger³

et al. 1970

J. Clin. Invest.

321

127

View full text Add to dashboard Cite

A B S T R A C T The role of glucagon in the metabolic adaptation to prolonged fasting in man has been examined. Plasma immunoreactive glucagon was determined during 6-wk fasts and during infusion of exogenous glucagon using an assay which minimized nonpancreatic immunoreactivity.Plasma glucagon concentrations rose twofold to a peak on the 3rd day of fasting and then declined thereafter to a level maintained at or above postabsorptive. Insulin concentration declined to a plateau by the 3rd day. Thus a persisting altered relationship of glucagon and insulin concentrations characterized the fasted state. A synergism of low insulin and relative or absolute elevation of glucagon levels is viewed as a hormonal mechanism controlling the rate of hepatic substrate extraction for gluconeogenesis.Glucagon was infused systemically into 4-6-wk fasted subjects at three dose levels. A marked sensitivity of individual plasma free amino acids to the induced elevations of plasma glucagon within the physiologic range was demonstrated. At higher concentrations, equivalent to those present in the portal vein, stimulation of hepatic gluconeogenesis occurred, and the effects on glucose, insulin, and growth hormone levels and on ketone metabolism were induced.

show abstract

Section: Discussionsupporting

confidence: 82%

Glucagon levels and metabolic effects in fasting man

Eb¹,

Aoki²,

Unger³

et al. 1970

J. Clin. Invest.

321

127

View full text Add to dashboard Cite

show abstract

“…Insulin (40 mU), glucagon (10 ~g), cortisol (0.1 mg), or solvent was administered at delivery. Glucose (10 mg) previous observations in adult human [33,34,35] and rabbit [36]. Since glucagon at the dose used stimulated insulin secretion by the fetal pancreas, the hypoaminoacidemia produced by glucagon must in part have been insulin-mediated.…”

Section: Plasma Amino Acidsmentioning

confidence: 91%

Effects of exogenous hormones and glucose on plasma levels and hepatic metabolism of amino acids in the fetus and in the newborn rat

Girard

Marty

et al. 1976

Diabetologia

View full text Add to dashboard Cite

The present study examines the role of insulin, glucagon and cortisol in the regulation of gluconeogenesis from lactate and amino acids in fetal and newborn rats. Injection of glucagon in the full-term fetal rat caused a rise in glucose (and insulin) and a fall in blood levels of most individual amino acids, stimulated hepatic accumulation of 14C-amino isobutyric acid and 14C-cycloleucine and increased the conversion of 14C lactate, alanine and serine to glucose in vivo and in vitro (liver slices). Such changes were equivalent to the changes seen in 4 h old newborn rats. When glucagon was administered at birth, little difference was observed between control and treated animals in plasma amino acids and a smaller increment in conversion of 14C substrate to glucose occurred. By contrast, insulin injection at birth caused hypoglycemia, suppression of levels of certain amino acids and inhibition of conversion of 14C substrates into glucose. Glucose injection at birth caused elevated glycemia and plasma insulin and suppression of most amino acid levels and of conversion of 14C substrate into glucose. Cortisol injection at birth caused a marked, generalized by hyperaminoacidemia, a stimulation of glucagon secretion and of conversion of 14C substrates into glucose. These observations support the thesis that glucagon plays a major role in the induction of hepatic gluconeogenesis and that insulin acts as an antagonist hormone.

show abstract

“…However, the biological half-life of conventional exogenous glucagon in plasma is short [2]. Zinc glucagon has a long biological half-life [3]. Continuous subcutaneous glucagon infusion (CSGI) is a new method of glucagon administration, and the half-life should be prolonged by this method.…”

Section: Discussionmentioning

confidence: 99%

Effect of Glucagon on Plasma Amino Acid and Glucose Levels in a Patient Who Had Undergone Total Pancreatectomy.

Yagi

Shimizu

Izumi

et al. 1993

J. Clin. Biochem. Nutr.

View full text Add to dashboard Cite

SummaryThe plasma glucose and amino acid levels of a patient who had undergone total gastrectomy and total pancreatectomy 15 years previously were examined under 4 conditions determined by the method of exogenous glucagon injection. Glucagon was not injected in the first period, and 1 mg of glucagon was injected twice a day in the second period. Twice a day 1 mg of zinc glucagon was injected in the third period, and 2 mg/day of glucagon by continuous subcutaneous glucagon infusion (CSGI) was given in the fourth period. The plasma pancreatic glucagon levels were within the normal range during CSGI. The effect of glucagon on plasma amino acid levels was greatest with CSGI. The effect became less in the order of zinc glucagon injection and twice-a-day injection of 1 mg of glucagon. Furthermore, afternoon hyperglycemia and nocturnal hypoglycemia were suppressed with CSGI. Urinary nitrogen excretion was increased with glucagon injection. However, excretion of 3-methylhistidine did not show any significant increase. From these results we consider that exogenous glucagon injection has significant effects on the metabolism of glucose and amino acids after total pancreatectomy. We also conclude that both continuous subcutaneous glucagon infusion and zinc glucagon are useful in the postoperative management of total pancreatectomy.

show abstract

Zinc Glucagon Depression of Blood Amino Acids in Rabbits

Cited by 21 publications

References 10 publications

Glucagon levels and metabolic effects in fasting man

Glucagon levels and metabolic effects in fasting man

Effects of exogenous hormones and glucose on plasma levels and hepatic metabolism of amino acids in the fetus and in the newborn rat

Effect of Glucagon on Plasma Amino Acid and Glucose Levels in a Patient Who Had Undergone Total Pancreatectomy.

Contact Info

Product

Resources

About