Zinc(II) complexes derived from pyridine-2-carbaldehyde thiosemicarbazone and (1E)-1-pyridin-2-ylethan-1-one thiosemicarbazone. Synthesis, crystal structures and antiproliferative activity of zinc(II) complexes

Kovala‐Demertzi, Dimitra; Yadav, Pravesh; Wiecek, Joanna; Skoulika, Stauroula; Varadinova, T.; Demertzis, Mavroudis A.

doi:10.1016/j.jinorgbio.2006.05.006

Cited by 121 publications

(66 citation statements)

References 23 publications

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“…Absence of the N(3)H signal in the complex, implies that anionic ligand was involved in coordination 9,11 . On coordination of the sulphur and imine nitrogen atoms the electron density would be expected to be lost from the H-C=N function, as has been observed for many complexes of thiosemicarbazones.…”

Section: Nmr Spectroscopymentioning

confidence: 98%

“…Small shift in ν(C-O) stretch in the complex compare to that in free ligand was due to different strength of hydrogen bond in two. The ν(C=S) vibration in the free ligand at 801 cm -1 appears at lower frequency with reduced intensity in the complex at 706 cm -1 , suggesting coordination of sulfur in the deprotonated thiolate form 8,9,10 .…”

Section: Ir Spectroscopymentioning

confidence: 99%

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Palladium(II) Complex of the 5-Hydroxypyridine-2-carbaldehyde N(4)-ethylthiosemicarbazone: Synthesis and Characterization

Yadav

Bhattrai

Mehta

2013

J. Nepal Chem. Soc.

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Section: Nmr Spectroscopymentioning

confidence: 98%

Section: Ir Spectroscopymentioning

confidence: 99%

Palladium(II) Complex of the 5-Hydroxypyridine-2-carbaldehyde N(4)-ethylthiosemicarbazone: Synthesis and Characterization

Yadav

Bhattrai

Mehta

2013

J. Nepal Chem. Soc.

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“…The MTT assessment was performed to study the cytotoxic activity (Kovala-Demertzi et al, 2006;Mosmann, 1983) through which this compound would be evaluated on viability breast cancer cell MCF-7. In 96-well plate (200 µL/well), the cells were coated with density of 2×10 5 per millilitre, then controlled with several concentrations (0.936, 0.468, 1.875, 3.75, 7.5, 15 and 30 µM/L) of the compound, then incubated for 72 h at 37°C where control breast cells did not have the compound.…”

Section: Synthesis Of 6-hydroxy-4-methylcoumarinmentioning

confidence: 99%

Synthesis and Biological Evaluation of 6-Hydroxy-4-Methyl-5,7-(Bis-p-ChlorophenylAzo) Coumarin

Ibrahim¹,

Jumal

Harun

2016

American Journal of Applied Sciences

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Abstract:6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo)coumarin has been synthesized and characterized by CHN elemental analysis, FTIR, 1 H-NMR-spectroscopy and mass-spectral data. Cytotoxic screening by MTT assay was carried out on the compound against breast cancer cells. The overall results from preliminary screening program revealed that the cell proliferation was highly inhibited by 6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo) coumarin with the value of 2.81%, at concentration of 30 µg mL −1 compared with the untreated control cells and also possessed a good chelating activity with IC 50 value 1.87 µg mL −1 . It is suggested that the cytotoxic activity is affected by hydroxyl and halogen groups as these groups have high electron affinity and high electronegativity.

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“…A disturbed metabolism and distribution of both copper and zinc results in inflammatory and degenerative conditions. Some complexes have also shown antiproliferative [24], antifungal [25], antibacterial [26] and antidiabetic activity [15,27].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and Antimicrobial Activities of Cu(II), Co(II), Pt(II) and Zn(II) Complexes with N,O‐Chelating Heterocyclic Carboxylates

Buczkowska

Bodtke

Lindequist

et al. 2011

Archiv der Pharmazie

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A series of Cu(II), Co(II), Pt(II) and Zn(II) coordination compounds has been prepared by the reaction of the metal chlorides with pyrazine-2-carboxylic acid, pyridine-2-carboxylic acid, imidazole-4-carboxylic acid, benzimidazole-2-carboxylic acid and 1-methylimidazole-2-carboxylic acid. The complexes were characterized by IR, UV-VIS, elemental analysis, and some by (1) H-NMR, X-ray crystallography, HPLC and LC/MS spectroscopy. All complexes consist of a 2:1 ratio of ligand to metal ion. IR and X-ray crystallography show that coordination is through the nitrogen and carboxylate oxygen donor atoms of the ligand to form chelating rings. DFT calculations predict that the trans-coordinated isomers are thermodynamically more stable than their cis-forms. Only one of five complexes studied by X-ray crystallography, Cu(II) complex of 1-methylimidazole-2-carboxylic acid showed a cis-configured metal ion center. HPLC analysis indicated that Pt(II) complex of 1-methylimidazole-2-carboxylic acid is dominated (>90%) by the trans-configured complex. All other complexes showed one isomer, presumably the trans-form. The cytotoxic activity was investigated in human cancer cell lines in vitro; only the Pt(II) complexes were active. The antimicrobial activity against four bacterial strains and one fungi was estimated by the MIC method and best results were found amongst the Co(II) complexes. These results indicate that trans-coordinated bischelating N,O-heterocyclic carboxylates of Pt(II) are an interesting new class of potential antitumor agents.

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Zinc(II) complexes derived from pyridine-2-carbaldehyde thiosemicarbazone and (1E)-1-pyridin-2-ylethan-1-one thiosemicarbazone. Synthesis, crystal structures and antiproliferative activity of zinc(II) complexes

Cited by 121 publications

References 23 publications

Palladium(II) Complex of the 5-Hydroxypyridine-2-carbaldehyde N(4)-ethylthiosemicarbazone: Synthesis and Characterization

Palladium(II) Complex of the 5-Hydroxypyridine-2-carbaldehyde N(4)-ethylthiosemicarbazone: Synthesis and Characterization

Synthesis and Biological Evaluation of 6-Hydroxy-4-Methyl-5,7-(Bis-p-ChlorophenylAzo) Coumarin

Cytotoxic and Antimicrobial Activities of Cu(II), Co(II), Pt(II) and Zn(II) Complexes with N,O‐Chelating Heterocyclic Carboxylates

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