Zinc oxide nano-particles as sealer in endodontics and its sealing ability

Abstract

Aims:The aim of this study was to evaluate the sealing ability of new experimental nano-ZOE-based sealer.Settings and Design:Three types of nano-ZOE-based sealer (calcined at different temperatures of 500, 600 and 700°C) with two other commercially available sealers (AH26 and micro-sized zinc oxide eugenol sealer) were used.Materials and Methods:Zinc oxide nano-particles were synthesized by a modified sol-gel method. The structure and morphology of the prepared powders were characterized using x-ray diffraction (XRD) and transmission electron microscopy (TEM) techniques. The instrumented canals of 60 single-rooted teeth were divided into five groups (n = 10), with the remaining ten used as controls. The canals were filled with gutta-percha using one of the materials mentioned above as sealer. After 3, 45 and 90 days, the samples were connected to a fluid filtration system.Statistical Analysis Used:The data were analyzed using Student's t-test.Results:The XRD patterns and TEM images revealed that all the synthesized powders had hexagonal wurtzite structures with an average particle size of about 30-60 nm at different calcination temperatures. Microleakage in AH26 groups was significantly more than that in three groups of ZnO nano-particles at all the three evaluation intervals. Apical microleakage of ZnO micro-powders was significantly more than that of all the materials, but the sealing ability of ZnO nano-powder sealers did not differ significantly.Conclusion:The results of this study showed that the synthesized ZnO nano-powder sealers are suitable for use as a nano-sealer in root canal therapy to prevent leakage; however, further studies should be carried out to verify their safety.

The Potential Translational Applications of Nanoparticles in Endodontics

“… 158 Obturation with gutta-percha and nano-zinc oxide eugenol sealer resulted in less apical microleakage compared to AH 26 TM and micro-zinc oxide eugenol sealer. 157 The cytotoxic effects of nano-zinc oxide eugenol sealer were reported to be not more than that of other commercially available sealers, such as AH 26 TM and Pulpdent TM . 159 When incorporated into polyethylene tubes implanted in rats, nano-zinc oxide eugenol sealer instigated similar tissue reactions compared to Pulp Canal Sealer TM and AH 26 TM .…”

“…ZnONPs have likewise been used to formulate novel endodontic sealers or modify existing zinc oxide eugenol sealers in order to improve physicochemical and antibacterial properties. 157 , 158 One of the first studies to highlight the potential uses of nanoparticles in endodontics incorporated ZnONPs, with or without chitosan nanoparticles, into a zinc oxide eugenol-based sealer, which resulted in improved antibacterial properties. 158 Obturation with gutta-percha and nano-zinc oxide eugenol sealer resulted in less apical microleakage compared to AH 26 TM and micro-zinc oxide eugenol sealer.…”

Positive and negative properties of four endodontic sealant groups: a systematic review

“…Исследования материала на основе цинк-оксид эвгенола показали лучшее качество адгезии силера к гуттаперче, чем к дентину, а также наличие дефектов заполнения (щели, микрополости) на протяжении всего корневого канала. Особенно сильно препятствует образованию химических связей с гуттаперчей, а также ухудшает адгезию между силером и филлером избыток порошка при замешивании материала [48].…”

Neuroinflammation is induced by tongue-instilled ZnO nanoparticles via the Ca2+-dependent NF-κB and MAPK pathways

“…Over the past few decades, nanotechnology has developed rapidly and emerged as a promising technique for various materials science, biomedical and daily life applications. Zinc oxide nanoparticles (ZnO NPs) are frequently used in dental materials, such as toothpaste [ 1 ], mouthwash, dental resin, root canal flings [ 2 ] and implant surface coatings [ 3 ]. The increased biological applications of ZnO NPs in stomatology provides a potential route for ZnO NPs to translocate into the human body.…”