The aim of the study was to evaluate the analgesic activity of paracetamol, analgin, dexalgin and placebo using electrical pulp sensitivity testing. Blind randomized study was performed on 112 volunteers, 52 men and 70 women aged 19-28 years. Pain threshold was measured before and 15, 30, 45 and 60 minutes after oral intake of medications using EOM-3 device. Paired t- and χ²-test was used for statistical analysis. Height effect was observed at 30 min: 9.4 mkA for analgin, 8.7 mkA for dexalgin, 6.5 mkA for paracetamol and 5.2 mkA for placebo. Paracetamol showed analgesic efficiency close to placebo effect.

Background. The choice of sealant is an important dentist’s decision with a long-term influence on treatment. Knowledge of the properties and characters of each material is key to the optimal endosealer selection on individual basis.Objectives. A comparison of endodontic sealants based on epoxy resins, calcium hydroxide, zinc oxide eugenol and bioceramics.Methods. Publications were mined in the PubMed and Google Scholar electronic databases to cover the four sealer groups (epoxy, calcium hydroxide, zinc oxide eugenol and bioceramics) over years 2014-2021, including selected relevant sources within 2002-2013; 73 articles were considered for review, regardless of the study design or language. Content and descriptive analyses were used as research tools. Meta-analysis was not used due to a high evidence heterogeneity.Results. The dental market currently offers a variety of sealant groups. Endodontic sealants based on epoxy resins, zinc oxide eugenol, calcium hydroxide and bioceramics are the most common. The review identifies no ideal material for the root canal filling.Conclusion. Manifold studies demonstrate the pros and cons in each endodontic sealant group with respect to variant criteria. Depending on clinical situation, the practitioner can opt for the material property to identify the endosealer.

Aim. То carry out a comparative assessment of the change in the pain threshold (in terms of electroodontometry), the X-ray width of the root canal in the apex area and the nature of the pain sensation of the central incisors in children aged 6.5-15 years.Materials and methods. We examined 280 teeth in 280 children from 6.5 to 15 years old (central incisors). Patients are divided by age into 5 groups: 1 - 6.5-7 years old; 2 - 7-8 years old; 3 - 9-10 years old; 4 - 11-12 years old; 5 - 13-15 years old. The patients underwent electroodontometry (EOM), to measure the sensitivity threshold of the studied tooth, the subjective sensations with EOM were assessed, and the width of the apical part of the root canal was determined, according to the data of intraoral sighting radiography.Results. The study studied the process of teething and formation of teeth in dynamics from 6.5 to 15 years in 5 age groups. Changes in electrodontometry (EOM) are significant from 140.38 цА (4.5 years) to 24.38 цА (15 years) - average data. The relationship between age and the width of the root canal in the area of the apex, which is also characterized by a gradual narrowing, has been traced. Pulp pain with EOM becomes clearer and more short-lived with age. The correlation between age and pain threshold is less pronounced (41%) than between age and apical canal width (72%). Conclusions. The main role in the sensitivity of the tooth is played by the A-delta and C nerve fibers of the pulp. The phenomenon of a decrease in the pain sensitivity threshold of permanent teeth during electrodontometry in the process of root formation due to the reaction of C-fibers was established.

Relevance. The reason for the study was our histological specimen with intrapulpal dye injection from the monograph "Anesthesia in Endodontics". Outside the pulp chamber, in the root canal, the ink is diffusely distributed throughout the vessels. There was a hypothesis about the vascular nature of intrapulpal injection.Aim. Тo prove vascular mechanism intrapulpal injection.Materials and methods. A randomized prospective pilot study was performed in 15 patients (9 men, 6 women) with 15 teeth vital pulpectomy. Traditional anesthesia conducted articaine 4% with epinephrine 1:100 000. When accessed in the pulpintroduced drop the same anesthetic. Heart rate was determined after 30 seconds for 3 minutes pulse oximeter MD 300.Results. There was expressed vascular reaction to intrapulpal introduction anesthetic with epinephrine. It has resulted in a sharp increase in pulse rate by an average of 11.3 beats /min, return to the original level after 3 minutes. Conclusions. Based on the results obtained, we assume the vascular-venous nature of intrapulpal anesthesia.

Aim. To assess the dependence of electrodontometry indicators on the configuration of the root canal and to determine the value of the resultant action of the current at which patients have a response to electrodontometry.Materials and methods. The research consisted in the creation of computer models of teeth and their analysis by the finite element method in the COMSOL Multiphysics program. The removed tooth 2.2 was chosen as a prototype for 3D computer models. The tooth was dissected into fragments 2 millimeters thick, from which the geometric parameters of hard tissues and the position of the root canal were removed. Based on these data, a 3D model of the tooth was built. Based on the 2.2 tooth model, 5 models of the same tooth were constructed, simulating the stages of its root formation.Results. In all models, with an increase in the channel width in the apex area from 0.3 mm to 2.55 mm, the current density in this area decreased from 26.92 A/m2 to 0.63 A/m2. The maximum current density in the models was recorded in the narrowest part of the root canal and ranged from 26.01 A/m2 to 26.75 A/m2.Conclusions. The strength of the diagnostic current that causes a response in patients during electrodontometry depends on the configuration of the root canal, namely, on the cross–sectional area in the narrowest part of the root canal, where the maximum current density is recorded. The current density at which patients have a response to electrodontometry is 26-27 A/m2.