Zinc oxide nanoparticles as contrast‐enhancing agents for microwave imaging

Lahri, Rachita; Rahman, Mohammed; Wright, Michael; Kosmas, Panagiotis; Thanou, Maya

doi:10.1002/mp.13062

Cited by 18 publications

(18 citation statements)

References 47 publications

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“…In the case of breast cancer, for example, the cancerous tissue contrast depends on the density of the healthy tissue surrounding the tumor. The malignant tumor contrast can range from 10:1 for adipose to 10% for dense fibroglandular tissue [ 5 ]; in the latter case, the use of suitable, nontoxic contrast agents [ 6 ] could provide a means of detection based on a differential imaging approach [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Design and Experimental Validation of a Multiple-Frequency Microwave Tomography System Employing the DBIM-TwIST Algorithm

Ahsan

Guo

Miao

et al. 2018

Sensors

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We present a first prototype of a wideband microwave tomography system with potential application to medical imaging. The system relies on a compact and robust printed monopole antenna which can operate in the 1.0–3.0 GHz range when fully immersed in commonly used coupling liquids, such as glycerine–water solutions. By simulating the proposed imaging setup in CST Microwave Studio, we study the signal transmission levels and array sensitivity for different target and coupling liquid media. We then present the experimental prototype design and data acquisition process, and show good agreement between experimentally measured data and results from the CST simulations. We assess imaging performance by applying our previously proposed two-dimensional (2-D) DBIM TwIST-algorithm to both simulated and experimental datasets, and demonstrate that the system can reconstruct simple cylindrical targets at multiple frequencies.

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Section: Introductionmentioning

confidence: 99%

Design and Experimental Validation of a Multiple-Frequency Microwave Tomography System Employing the DBIM-TwIST Algorithm

Ahsan

Guo

Miao

et al. 2018

Sensors

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“…3). 42 Research in these microwave-sensitive materials has provided the foundation for contrast agent exploration, with studies moving into model systems and in some cases in vivo work. This has also been explored in stroke detection, where the administration of superparamagnetic iron oxide NPs was used to enhance image reconstruction through increased signal attenuation.…”

Section: Nanoparticles and Nanomaterials As Potential Contrast Agents For Microwave Imagingmentioning

confidence: 99%

Nanomaterials responding to microwaves: an emerging field for imaging and therapy

et al. 2021

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“…ZnO NPs is often used in daily life as an additive in sunscreen products so that it can be in direct contact with human skin. In the field of biomedicine, it is widely used in biological imaging and antibacterial and anti-tumor applications [63][64][65]. Especially in the antibacterial field, it has a strong and broad-spectrum antibacterial effect on both gram-positive and gram-negative bacteria [66].…”

Section: Metal Oxide Nmsmentioning

confidence: 99%

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

Feng

Zhang

et al. 2020

Part Fibre Toxicol

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Background Widespread biomedical applications of nanomaterials (NMs) bring about increased human exposure risk due to their unique physicochemical properties. Autophagy, which is of great importance for regulating the physiological or pathological activities of the body, has been reported to play a key role in NM-driven biological effects both in vivo and in vitro. The coexisting hazard and health benefits of NM-mediated autophagy in biomedicine are nonnegligible and require our particular concerns. Main body We collected research on the toxic effects related to NM-mediated autophagy both in vivo and in vitro. Generally, NMs can be delivered into animal models through different administration routes, or internalized by cells through different uptake pathways, exerting varying degrees of damage in tissues, organs, cells, and organelles, eventually being deposited in or excreted from the body. In addition, other biological effects of NMs, such as oxidative stress, inflammation, necroptosis, pyroptosis, and ferroptosis, have been associated with autophagy and cooperate to regulate body activities. We therefore highlight that NM-mediated autophagy serves as a double-edged sword, which could be utilized in the treatment of certain diseases related to autophagy dysfunction, such as cancer, neurodegenerative disease, and cardiovascular disease. Challenges and suggestions for further investigations of NM-mediated autophagy are proposed with the purpose to improve their biosafety evaluation and facilitate their wide application. Databases such as PubMed and Web of Science were utilized to search for relevant literature, which included all published, Epub ahead of print, in-process, and non-indexed citations. Conclusion In this review, we focus on the dual effect of NM-mediated autophagy in the biomedical field. It has become a trend to use the benefits of NM-mediated autophagy to treat clinical diseases such as cancer and neurodegenerative diseases. Understanding the regulatory mechanism of NM-mediated autophagy in biomedicine is also helpful for reducing the toxic effects of NMs as much as possible.

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Zinc oxide nanoparticles as contrast‐enhancing agents for microwave imaging

Abstract: These results suggest that ZnO nanomaterials have the potential to be used in biomedical applications such as breast imaging to improve diagnostic capabilities.

Cited by 18 publications

References 47 publications

Design and Experimental Validation of a Multiple-Frequency Microwave Tomography System Employing the DBIM-TwIST Algorithm

Design and Experimental Validation of a Multiple-Frequency Microwave Tomography System Employing the DBIM-TwIST Algorithm

Nanomaterials responding to microwaves: an emerging field for imaging and therapy

Nanomaterial-mediated autophagy: coexisting hazard and health benefits in biomedicine

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