Zinc Protects against Heat Stress–Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in TM3 Leydig Cells

Xiong, Yi; Li, Jing; He, Shang

doi:10.1007/s12011-021-02673-7

Cited by 15 publications

(3 citation statements)

References 50 publications

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“…In the human keratinocyte cell line HaCaT, Zn also prevented the apoptogenic effects of ropivacaine [71]. Similarly, Zn supplementation protected TM3 Leydig cells from heat stress-induced apoptosis, via ER stress inhibition [72].…”

Section: Zn and Cell Deathmentioning

confidence: 92%

Zinc: From Biological Functions to Therapeutic Potential

Costa

Sarmento‐Ribeiro

Gonçalves

2023

IJMS

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The trace element zinc (Zn) displays a wide range of biological functions. Zn ions control intercellular communication and intracellular events that maintain normal physiological processes. These effects are achieved through the modulation of several Zn-dependent proteins, including transcription factors and enzymes of key cell signaling pathways, namely those involved in proliferation, apoptosis, and antioxidant defenses. Efficient homeostatic systems carefully regulate intracellular Zn concentrations. However, perturbed Zn homeostasis has been implicated in the pathogenesis of several chronic human diseases, such as cancer, diabetes, depression, Wilson’s disease, Alzheimer’s disease, and other age-related diseases. This review focuses on Zn’s roles in cell proliferation, survival/death, and DNA repair mechanisms, outlines some biological Zn targets, and addresses the therapeutic potential of Zn supplementation in some human diseases.

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Section: Zn and Cell Deathmentioning

confidence: 92%

Zinc: From Biological Functions to Therapeutic Potential

Costa

Sarmento‐Ribeiro

Gonçalves

2023

IJMS

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“…In addition, the effects of oxidative stress on Leydig cells have been briefly reviewed in recent studies [ 102 , 108 ]. Heat stress treatment inhibited cell viability, induced apoptosis, increased the activity of caspase 3 and the pro-apoptotic protein Bax, and decreased the expression of anti-apoptotic protein B-cell leukemia/lymphoma-2 (Bcl-2), concurrently activating endoplasmic reticulum (ER) stress markers such as glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP) [ 109 ].…”

Section: Impact Of Heat-stress-induced Oxidative Stress and Apoptosis...mentioning

confidence: 99%

Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis

Khan,

Chen

et al. 2024

Antioxidants

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Heat stress represents a pervasive global concern with far-reaching implications for the reproductive efficiency of both animal and human populations. An extensive body of published research on heat stress effects utilizes controlled experimental environments to expose cells and tissues to heat stress and its disruptive influence on the physiological aspects of reproductive phenotypic traits, encompassing parameters such as sperm quality, sperm motility, viability, and overall competence. Beyond these immediate effects, heat stress has been linked to embryo losses, compromised oocyte development, and even infertility across diverse species. One of the primary mechanisms underlying these adverse reproductive outcomes is the elevation of reactive oxygen species (ROS) levels precipitating oxidative stress and apoptosis within mammalian reproductive cells. Oxidative stress and apoptosis are recognized as pivotal biological factors through which heat stress exerts its disruptive impact on both male and female reproductive cells. In a concerted effort to mitigate the detrimental consequences of heat stress, supplementation with antioxidants, both in natural and synthetic forms, has been explored as a potential intervention strategy. Furthermore, reproductive cells possess inherent self-protective mechanisms that come into play during episodes of heat stress, aiding in their survival. This comprehensive review delves into the multifaceted effects of heat stress on reproductive phenotypic traits and elucidates the intricate molecular mechanisms underpinning oxidative stress and apoptosis in reproductive cells, which compromise their normal function. Additionally, we provide a succinct overview of potential antioxidant interventions and highlight the genetic biomarkers within reproductive cells that possess self-protective capabilities, collectively offering promising avenues for ameliorating the negative impact of heat stress by restraining apoptosis and oxidative stress.

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“…In another study, in seminiferous tubules, quercetin supplementation decreased the rate of apoptosis of germ cells while maintaining the interstitial stroma, seminiferous tubule architecture, germinal, and Sertoli cells under heat stress conditions [ 96 ]. Study showed, in TM3 Leydig cells exposed to heat stress, zinc supplementation was demonstrated to be a possible protective factor against apoptosis and decreased testosterone synthesis [ 97 ]. In conclusion, supplementation with the abovementioned antistress remedies and implementing management measures should enable the minimization of the risk of heat stress–induced infertility in stallions.…”

Section: Possible Supplementation and Management Measures For Prevent...mentioning

confidence: 99%

Heat stress and stallion fertility

Shakeel¹,

Yoon²

2023

J Anim Sci Technol

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Competing interestsNo potential conflict of interest relevant to this article was reported Funding sourcesState funding sources (grants, funding sources, equipment, and supplies). Include name and number of grant if available. Not applicable Availability of data and materialPlease specify the authors' role using this form. M.S.: Writing -original draft, validation, and visualization. Ethics approval and consent to participateThis article does not require IRB/IACUC approval because there are no human and animal participants.

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Zinc Protects against Heat Stress–Induced Apoptosis via the Inhibition of Endoplasmic Reticulum Stress in TM3 Leydig Cells

Cited by 15 publications

References 50 publications

Zinc: From Biological Functions to Therapeutic Potential

Zinc: From Biological Functions to Therapeutic Potential

Advancements in Genetic Biomarkers and Exogenous Antioxidant Supplementation for Safeguarding Mammalian Cells against Heat-Induced Oxidative Stress and Apoptosis

Heat stress and stallion fertility

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