Zinc restriction during different periods of life: Influence in renal and cardiovascular diseases

Tomat, Analia Lorena; Costa, María A.; Arranz, Cristina

doi:10.1016/j.nut.2010.09.010

Cited by 95 publications

(58 citation statements)

References 63 publications

(98 reference statements)

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“…The low Zn concentrations in blood and scalp hair correlate with intake of cardiovascular medication and also with reduced protein intake [31]. Several epidemiological studies reported that low concentrations of Zn in serum and high urinary Zn concentrations were found in patients of CVD [32,33]. Animal study found that supplementation with Zn reduced the oxidative damage and TNF-α levels and improved both dyslipidemia and angiogenesis in rat; thus, daily supplementation with Zn is promising for improving myocardial performance via preventing oxidative damage, induction of angiogenesis, anti-inflammatory, and/ or anti-hyperlipidemic mechanisms [28].…”

Section: Discussionmentioning

confidence: 99%

Deficient Zinc Levels and Myocardial Infarction

Liu¹,

Cai

Zhou³

2015

Biol Trace Elem Res

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The purpose of this study is to clarify the association between Zn levels and myocardial infarction (MI) using a meta-analysis approach. We searched articles in the PubMed, OVID, and ScienceDirect published as of November 2014. Thirteen eligible articles with 2886 subjects from 41 case-control studies were identified. Overall, pooled analysis indicated that subjects with MI had lower Zn levels than healthy controls (standardized mean difference (SMD) = -1.848, 95 % confidence interval (CI) = [-2.365, -1.331]). Further subgroup analysis found that subjects with MI had lower Zn levels than healthy controls in serum (SMD = -1.764, 95 % CI = [-2.417, -1.112]) and hair (SMD = -3.326, 95 % CI = [-4.616, -2.036]), but not in toenail (SMD = -0.396, 95 % CI = [-1.114, 0.322]). The subgroup analysis stratified by type of Zn measurement found a similar pattern in inductively coupled plasma-atomic absorption spectrometry (ICP-AAS) (SMD = -2.442, 95 % CI = [-3.092, -1.753]), but not in neutron activation analysis (NAA) (SMD = -0.449, 95 % CI = [-1.127, 0.230]). Lower Zn levels in MI patients were found both in male (SMD = -3.350, 95 % CI = [-4.531, -2.169]) and female (SMD = -2.681, 95 % CI = [-3.440, -1.922]). And the difference of Zn levels according to MI in Asia (SMD = -2.555, 95 % CI = [-3.267, -1.844]) was greater to that among the population in Europe (SMD = -0.745, 95 % CI = [-1.386, -0.104]), but no difference was found in Oceania (SMD = -0.255, 95 % CI = [-0.600, 0.089]). In conclusion, this meta-analysis indicates that there is a significant association between Zn deficiency and MI. We suggest that a community-based, long-term observation in a cohort design should be performed to obtain better understanding of causal relationships between Zn and MI, through measuring hair Zn at baseline to investigate whether the highest zinc category versus lowest was associated with MI risk.

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Section: Discussionmentioning

confidence: 99%

Deficient Zinc Levels and Myocardial Infarction

Liu¹,

Cai

Zhou³

2015

Biol Trace Elem Res

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“…It was demonstrated in experimental studies that intrauterine exposure to zinc restriction may contribute to elevated arterial blood pressure and kidney lesions in later life. Among the renal disturbances, decreased number and size of nephrons and the related reduced glomerular filtration rate, as well as proteinuria and raised renal apoptosis and fibrosis, were observed 51,52. In addition, intrauterine zinc deficiency may contribute to decreased insulin sensitivity and augmented weight gain in later life 53…”

Section: Maternal Malnutritionmentioning

confidence: 99%

Intrauterine nutrition: long-term consequences for vascular health

Szostak-Węgierek¹

2014

IJWH

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There is a growing body of evidence that improper intrauterine nutrition may negatively influence vascular health in later life. Maternal malnutrition may result in intrauterine growth retardation and, in turn, metabolic disorders such as insulin resistance, diabetes, hypertension, and dyslipidemia, and also enhanced risk of atherosclerosis and cardiovascular death in the offspring. Energy and/or protein restriction is the most critical determinant for fetal programming. However, it has also been proposed that intrauterine n-3 fatty acid deficiency may be linked to later higher blood pressure levels and reduced insulin sensitivity. Moreover, it has been shown that inadequate supply of micronutrients such as folate, vitamin B12, vitamin A, iron, magnesium, zinc, and calcium may contribute to impaired vascular health in the progeny. In addition, hypertensive disorders of pregnancy that are linked to impaired placental blood flow and suboptimal fetal nutrition may also contribute to intrauterine growth retardation and aggravated cardiovascular risk in the offspring. On the other hand, maternal overnutrition, which often contributes to obesity and/or diabetes, may result in macrosomia and enhanced cardiometabolic risk in the offspring. Progeny of obese and/or diabetic mothers are relatively more prone to develop obesity, insulin resistance, diabetes, and hypertension. It was demonstrated that they may have permanently enhanced appetites. Their atheromatous lesions are usually more pronounced. It seems that, particularly, a maternal high-fat/junk food diet may be detrimental for vascular health in the offspring. Fetal exposure to excessive levels of saturated fatty and/or n-6 fatty acids, sucrose, fructose and salt, as well as a maternal high glycemic index diet, may also contribute to later enhanced cardiometabolic risk.

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“…Efforts to explore the effects of Zn deficiency in women are hampered by the inability to accurately assess Zn status (4). Studies in animal models illustrate that marginal maternal Zn deficiency impairs bone development (8) and immunocompetence (9) and is associated with insulin resistance, obesity (10), and hypertension (11) in rat offspring. We previously found that moderate maternal Zn deficiency in rats reduces milk secretion (12), which may have important implications for nutrient transfer and the overall health and development of the nursing infant.…”

Section: Introductionmentioning

confidence: 99%

Marginal Maternal Zinc Deficiency in Lactating Mice Reduces Secretory Capacity and Alters Milk Composition ,

Dempsey

McCormick

Croxford

et al. 2012

The Journal of Nutrition

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Dietary analysis predicts that marginal Zn deficiency is common in women of reproductive age. The lack of reliable biomarkers limits the capacity to assess Zn status and consequently understand effects of maternal Zn deficiency. We determined effects of marginal maternal Zn deficiency on mammary gland function, milk secretion, and milk composition in mice. Mice (n = 12/diet) were fed marginal (ZD; 15 mg Zn/kg diet) or adequate (ZA; 30 mg Zn/kg diet) Zn diets for 30 d prior to conception through mid-lactation. Mice fed the ZD had a higher plasma Zn concentration (~20%; P < 0.05) but lower milk Zn concentration (~15%; P < 0.05) compared with mice fed the ZA. ZnT2 abundance was higher (P < 0.05) in mice fed the ZD compared with mice fed the ZA; no effect on ZnT4 abundance was detected. The Zn concentration of mammary gland mitochondria tended to be ~40% greater in mice fed ZD (P = 0.07); this was associated with apoptosis and lower milk secretion (~80%; P < 0.01). Total milk protein was ~25% higher (P < 0.05), although the abundance of the major milk proteins (caseins and whey acidic protein) was lower (P < 0.05) in mice fed the ZD. Proteomic analysis of milk proteins revealed an increase (P < 0.05) in four proteins in mice fed the ZD. These findings illustrate that marginal maternal Zn deficiency compromises mammary gland function and milk secretion and alters milk composition. This suggests that lactating women who consume inadequate Zn may not produce and/or secrete an adequate amount of high quality milk to provide optimal nutrition to their developing infant.

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Zinc restriction during different periods of life: Influence in renal and cardiovascular diseases

Cited by 95 publications

References 63 publications

Deficient Zinc Levels and Myocardial Infarction

Deficient Zinc Levels and Myocardial Infarction

Intrauterine nutrition: long-term consequences for vascular health

Marginal Maternal Zinc Deficiency in Lactating Mice Reduces Secretory Capacity and Alters Milk Composition ,

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